Base-Promoted Formal (3 + 2) Cycloaddition of α-Halohydroxamates with Electron-Deficient Alkenyl-iminoindolines To Synthesize Spiro-indolinepyrrolidinones
Xiang Zhang,
Hai-Yu Dai,
Wan-Cong Liu
et al.
Abstract:Construction
of pyrrolidinyl-spiroindoles with easily available
starting materials has attracted considerable attention from the synthesis
community and is in great demand. Here, we describe a base-promoted
formal (3 + 2) cycloaddition of α-halohydroxamates with alkenyl-iminoindolines.
The present methodology features mild reaction conditions and a broad
substrate scope with up to 99% yield and excellent diastereoselectivity.
The versatility of this approach is demonstrated through valuable
synthetic transform… Show more
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