Base of skull and cervical spine chordomas in children treated by high-dose irradiation

Benk, Veronique; Liebsch, Norbert J.; Munzenrider, John E.; Efird, James T.; McManus, Patricia; Suit, Herman D.

doi:10.1016/0360-3016(94)00395-2

Cited by 133 publications

(79 citation statements)

References 22 publications

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“…If they are IC, cranial nerve palsies are seen in 60% or so. 10,30 Non specific symptoms of hydrocephalus are present in one-third of cases. 31 Cervical-S sites or extension include also frequently stiff neck and nasal obstruction.…”

Section: Review Of Literaturementioning

confidence: 99%

“…[32][33][34] As for metastases, they are rare at presentation in all agegroups (<5%, except SC ≤25%). 11,14,30,35 Dissemination within the CNS, similar to the natural history of medulloblastomas, has been exceptionally reported. 36 Many practitioners with limited experience in this tumor type point out to their patients that CH is a benign process.…”

Section: Review Of Literaturementioning

confidence: 99%

“…Quality of resection based on modern imaging techniques (MRI, neuronavigation, endoscopy) and on modern surgical techniques (laser, microsurgery) has been substantially improved, but incomplete resection remains frequent in children: 0-36% in literature. 7,11,30,35 Metallic fixations can be requested for spinal consolidation. As they call for metallic material (rods, screws, cages) they can pose additional challenges to particle therapy, both at the time of simulation (requesting a MV CT simulator), and in treatment (multiple beam-angle restrictions, related with potential alterations of the particles path).…”

Section: Review Of Literaturementioning

confidence: 99%

“…[45][46][47][48]51,53 Pediatric CHs seem to fare better compared with their adult counterparts: 60-100% and 80-100%, respectively. 13,30,50,54,55 Nonetheless, younger children were frequently excluded in earlier series dealing with protons (since they require special attention, such as general anesthesia). Younger patients (i.e.…”

Section: Review Of Literaturementioning

confidence: 99%

“…7,11,30,60 Polychemotherapy regimens have been administered with drugs similar to soft part sarcomas (ifosfamide, doxorubicin, etoposide), and again mainly indicated where local treatment had failed previously. Few very young children have been managed with upfront chemotherapy, due to an extensive presentation of the disease locally and/or distantly.…”

Section: Review Of Literaturementioning

confidence: 99%

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Reprint of “Chordoma in children: Case-report and review of literature”

Habrand

Datchary

Bolle

et al. 2016

Reports of Practical Oncology & Radiotherapy

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Sarcoma Protontherapy Children a b s t r a c tWe report an exceptional case of a very late local failure in a 9-year-old boy presenting with a chordoma of the cranio-cervical junction. The child was initially treated with a combination of surgical resection followed by high dose photon-proton radiation therapy. This aggressive therapy allowed a 9-year remission with minimal side-effects. Unfortunately, he subsequently presented with a local failure managed with a second full-dose course of protons. The child died one year later from local bleeding of unclear etiology.© 2015 Greater Poland Cancer Centre. Published by Elsevier Sp. z o.o. All rights reserved. IntroductionChordomas ( with the brachyury gene, a gene involved in the notochord development. 5,6 In the adults, they are located typically in the sacrococcygeal (SC) (50%), the intra cranial (IC), at the skull base (SB) (35%), and the intermediate spinal (S) regions (15%). Only 5% of cases have been described in the pediatric age, with unclear specificities concerning presentation, and outcome. We report in this paper a clinical case of skull base CH http://dx

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Section: Review Of Literaturementioning

confidence: 99%

Section: Review Of Literaturementioning

confidence: 99%

Section: Review Of Literaturementioning

confidence: 99%

Section: Review Of Literaturementioning

confidence: 99%

Section: Review Of Literaturementioning

confidence: 99%

See 3 more Smart Citations

Reprint of “Chordoma in children: Case-report and review of literature”

Habrand

Datchary

Bolle

et al. 2016

Reports of Practical Oncology & Radiotherapy

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Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base

Combs

Nikoghosyan

Jaekel

et al. 2009

Cancer

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We present a tensorial elastic network model (TNM) to describe the equilibrium fluctuations of proteins near their native fold structure. The model combines the anisotropic network model (ANM), bond bending elasticity, and backbone twist elasticity, and can predict both the isotropic fluctuations, similar to the Gaussian network model (GNM), and anisotropic fluctuations, similar to the ANM. TNM performs equally well for B‐factor predictions as GNM and predicts the anisotropy of B‐factors better than ANM. The model also outperforms the ANM in its predictability of the complete anisotropic displacement parameters. Proteins 2012; © 2012 Wiley Periodicals, Inc.

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Highly effective treatment of skull base chordoma with carbon ion irradiation using a raster scan technique in 155 patients: First long‐term results

Uhl

Mattke

Welzel

et al. 2014

Cancer

131

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BACKGROUND:The current study was conducted to evaluate the long-term results of irradiation with carbon ions in a raster scanning technique in patients with skull base chordomas. METHODS: Between 1998 and 2008, a total of 155 patients (76 men and 79 women) with a median age of 48 years (range, 15 years-85 years) were irradiated with carbon ions using a raster scan technique. The irradiation was performed at the Society for Heavy Ion Research in Darmstadt, Germany. The median total dose was 60 gray (relative biological effectiveness) at 3 gray (relative biological effectiveness) per fraction. The median boost planning target volume was 70 mL (range, 2 mL-294 mL). Local control (LC) and overall survival (OS) were evaluated using the Kaplan-Meier method, whereas long-term toxicity was evaluated via questionnaires. RESULTS: The median follow-up was 72 months (range, 12 months-165 months). All patients had residual macroscopic tumors at the initiation of radiotherapy. The authors observed 55 local recurrences during follow-up, as well as systemic disease progression in 4 patients. The resulting 3-year, 5-year, and 10-year LC rates were 82%, 72%, and 54%, respectively, whereas the 3-year, 5-year, and 10-year OS rates were 95%, 85%, and 75%, respectively. Age <48 years and a boost volume >75 mL were associated with a significantly improved LC and OS. Primary treatment resulted in a significantly better OS probability. No higher late toxicity could be detected after carbon ion treatment. CONCLUSIONS: Carbon ion therapy appears to be a safe and effective treatment for patients with skull base chordoma, resulting in high LC and OS rates. Cancer 2014;120:3410-7.

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Base of skull and cervical spine chordomas in children treated by high-dose irradiation

Cited by 133 publications

References 22 publications

Reprint of “Chordoma in children: Case-report and review of literature”

Reprint of “Chordoma in children: Case-report and review of literature”

Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base

Highly effective treatment of skull base chordoma with carbon ion irradiation using a raster scan technique in 155 patients: First long‐term results

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