Base-mediated allylation of N-2,2,2-trifluoroethylisatin ketimines and its application in aza-Prins reactions

Kim, Jaehwan; Park, Se Yeon; Jung, Myeongjin; Jang, Woo Cheol; Ko, Haye Min

doi:10.1016/j.tetlet.2021.153512

Cited by 3 publications

(1 citation statement)

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“…To solve this problem, Ko’s group also developed a step-by-step process based on this study in the same year that overcame the limitations of the one-pot method and successfully performed the [3 + 3] aza-Prins cyclization reaction with TMSX (X=Cl, I, etc.) [ 63 ].…”

Section: Organocatalytic Reactions Involving N -22...mentioning

confidence: 99%

Recent Advances of N-2,2,2-Trifluoroethylisatin Ketimines in Organic Synthesis

Liu

Wang

et al. 2023

Molecules

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The special properties of fluorine atoms and fluorine-containing groups have led to an increasing number of applications for fluorine-containing organic compounds, which are also extremely widely used in the field of new drug development. Unfortunately, naturally fluorinated organics are rare in nature, so the selective introduction of fluorine atoms or fluorine-containing groups into organic molecules is very important for pharmaceutical/synthetic chemists. N-2,2,2-trifluoroethylisatin ketimines have received the attention of many chemists since they were first developed as fluorine-containing synthons in 2015. This paper reviews the organic synthesis reactions in which trifluoroethyl isatin ketimine has been involved in recent years, focusing on the types of reactions and the stereoselectivity of products, and also provides a prospect of its application in this field.

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Section: Organocatalytic Reactions Involving N -22...mentioning

confidence: 99%