Base Induced Condensation of Malononitrile with Erlenmeyer Azlactones: An Unexpected Synthesis of Multi‐Substituted Δ²‐Pyrrolines and Their Cytotoxicity

Abstract

An efficient, metal free approach to synthesize multi-substituted Δ 2 -pyrroline derivatives by mild base catalyzed cyclocondensation of malononitrile with Erlenmeyer azlactones via 1,2 addition was developed. The modularity of this reaction was used to assemble a range of poly-substituted pyrrolines. Further, synthesized products were screened for cytotoxic properties on different cancer cell lines such as A549 (Human lung adenocarcinoma cells), HeLa (Human cervical adenocarcinoma cells), Jurkat (Human chronic myeloid leukemia cells) and K562 (Human leukemic T cell Lymphoblast cells). Among the synthesized library of compounds, 6f and 6q displayed potent cytotoxic activity.

Synthesis, characterization and antibacterial evaluation of N‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amine derivatives

“…Our research group is frequently involved in the synthesis of novel nitrogen containing heterocyclic compounds like quinolones, pyrazoles, thiazoles, oxazole, quinoxalines etc., [24][25][26][27]. Encouraged by these observations and continuation of our efforts towards the synthesis of antisalmonella agents, we have synthesized morpholine conjugated quinoxalines (5a-j) (5ab, 5ac) and screened for their invitro antibacterial activity.…”