Base excess can be misleading in acute respiratory acidosis

Kocsi, Szilvia; Kiss, K.; Szerdahelyi, B; Demeter, Marylee; Molnár, Z.

doi:10.1186/cc9556

Crit Care

2011

DOI: 10.1186/cc9556

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Base excess can be misleading in acute respiratory acidosis

Szilvia Kocsi

K. Kiss

B Szerdahelyi

et al.

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Cited by 5 publications

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“…Alternatively, the results may reflect actual observations from acute clinical practice. Indeed, base excess's carbon dioxide invariance has not been established in vivo, let alone in patients with deranged buffer equilibria 6,7 …”

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confidence: 99%

“…Indeed, base excess's carbon dioxide invariance has not been established in vivo, let alone in patients with deranged buffer equilibria. 6,7 Second, 25% of respondents consider base excess a superior marker for tissue hypoperfusion. This is notable as lactate is directly produced by anaerobic metabolism, whilst base excess is a calculated surrogate measure that indirectly measures the resulting metabolic acidosis.…”

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confidence: 99%

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Base excess and lactate for guidance of peri-operative fluid management

Heldeweg,

Stohlmann,

Loer

2023

European Journal of Anaesthesiology

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confidence: 99%

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confidence: 99%

Base excess and lactate for guidance of peri-operative fluid management

Heldeweg,

Stohlmann,

Loer

2023

European Journal of Anaesthesiology

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The health and economic burden of antimicrobial resistance

Ouakrim

Cassini

Cecchini

et al. 2020

European Journal of Public Health

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Antimicrobial resistance (AMR) has profound consequences for the treatment of infections. By limiting treatment options, it often makes it necessary to resort to antibiotics with a broader spectrum of action some of which are potentially less effective or safe than narrow-spectrum antibiotics. This limitation in our ability to treat infections effectively has an impact on health care budgets but also broader and potentially disastrous consequences on a variety of economic sectors. This presentation provides an overview of the health and economic burden of AMR. It first presents the current state of knowledge on the epidemiology of AMR and discusses the main analytical challenges in determining the current and long-term effects of resistance on populations in terms of morbidity, mortality, and length of hospital stay. In addition, a summary of the current literature on the economic impact of AMR is provided along with a detailed discussion of the characteristics and limitations of existing economic models. Finally, it identifies the main knowledge gaps and suggests avenues for future research and approaches to address them.

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Tackling antimicrobial resistance in the community

Tonkie-Crine

Abel

Hecke

et al. 2020

European Journal of Public Health

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Antibiotic prescription is a major driver of antibiotic resistance. The majority of antibiotic prescribing occurs in community care settings, often for respiratory infections. A substantial proportion of prescriptions are issued not according to guidelines, particularly for acute respiratory infections which can be self-limiting. Prescribers in these settings need support to prescribe antibiotics more prudently. Patients and the public also need support to manage infections which are self-limiting. This presentation presents a summary of how antimicrobial stewardship (AMS) activities are being used in community settings. Firstly, types of community-level interventions are discussed, including those aimed at clinicians, patients and the public. Next, we assess interventions based on their effectiveness at reducing antibiotic prescriptions or use and their cost-effectiveness. Finally, we discuss directions for future research and consider how the research to date could influence policy.

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Base excess can be misleading in acute respiratory acidosis

Cited by 5 publications

References 2 publications

Base excess and lactate for guidance of peri-operative fluid management

Base excess and lactate for guidance of peri-operative fluid management

The health and economic burden of antimicrobial resistance

Tackling antimicrobial resistance in the community

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