Base excess

Evaluation of the prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP)

“…BE is a laboratory term to describe the imbalance of acid-base metabolism such as alkalosis and acidosis. The positive number of BE indicates an excess of base or lack of acid, while the negative number of BE indicates an excess of acid or lack of base [24]. In the present study, the median (range) BE value was 5.6 (0 -26.7) mmol/L, all of the BE values were ≥ 0 mmol/L, indicating that these patients with SCAP suffering from an excess of base or lack of acid.…”

Base deficit as an early marker of coagulopathy in trauma

“…The BD is defined as the amount of milli-equivalents of base required to titrate a litre of blood to a pH of 7.4 at an arterial partial pressure of carbon dioxide (PaCO 2 ) of 40 mmHg. [6] This measurement is unaffected by acute changes in PaCO 2 , is universally elevated in the presence of all pathological changes that induce a metabolic acidosis, and as such is a more reliable marker of the severity of the underlying metabolic state than pH, which will be altered by respiratory compensation. In the trauma setting, increased lactate production arises from anaerobic metabolism as a consequence of hypoperfusion, most commonly due to haemorrhage, but will not be affected by a metabolic acidosis that arises under aerobic conditions.…”

“…In the trauma setting, increased lactate production arises from anaerobic metabolism as a consequence of hypoperfusion, most commonly due to haemorrhage, but will not be affected by a metabolic acidosis that arises under aerobic conditions. Despite the fact that the BD not only reflects the degree of lactate accumulation but also provides a more composite view of a patient's metabolic status, [6,7] lactate clearance has been more popular than BD as a predictor of mortality in the trauma population. [8] Davis [9] showed a strong correlation between BD and lactate in a porcine haemorrhagic shock model and concluded that the BD was as accurate a marker of tissue hypoperfusion as lactate.…”

Venous and arterial base deficits

“…BD was measured by standard laboratory measurement, a calculated measurement based on HCO 3 and Ph. 13 This study was performed in a 450-bed university teaching hospital with a 17-bed TNICU (with four step-down beds) that cares for approximately 600 patients a year with an Injury Severity Score 915.…”