Base-catalyzed reaction of .beta.-amino alcohols with ethyl trihaloacetates

Synthesis of 1,2-Diamino-1-phenylpropane Diastereoisomers from u-N-Trifluoroacetyl-2-amino-1-phenylpropan-1-ol

“…To a solution of 3.9 g of u-2 (25.8 mmol) in 100 cm 3 C-1), 51.9 (C-2), 13.8 (C-3) ppm; IR was identical to published one [21]; MS analysis gave data similar to those of Ref. [22].…”

1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis

“…377 Trichloroacetate esters and carbonyl diimidazole provide alternative activation methods to achieve cyclization. 356,378,379 Some of these methods can be coupled to the reduction and provide a "one-pot" procedure from an amino acid to oxazolidinone. 372,373 N-(Ethoxycarbonyl)amino esters 92 can be reduced efficiently with sodium borohydride-calcium chloride and then cyclized in the presence of potassium carbonate in toluene under reflux to the corresponding oxazolidinone (Scheme 72).…”

“…Cyclization with tosyl chloride can be achieved with amino alcohol derivatives if the amino group is protected as the N -methylated Boc derivative ,, Some of these methods can be coupled to the reduction and provide a “one-pot” procedure from an amino acid to oxazolidinone. , …”