BASANT, a Polyherbal Safe Microbicide Eliminates HPV-16 in Women with Early Cervical Intraepithelial Lesions

Talwar, G. P.; Sharma, Rajani; Singh, Sonal; Das, Bhudev C.; Bharti, Alok C.; Sharma, Kavita; Singh, Priyanka; Atrey, Nishu; Gupta, Jagdish C.

doi:10.4236/jct.2015.614126

Cited by 39 publications

(4 citation statements)

References 7 publications

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“…All the 11 HPV-infected women with low-grade cervical lesions enrolled in a placebo-controlled phase I trial with basant, cleared HPV-16 infection upon basant application ( Supplementary Table S1 , curcumin-based formulation no.3) [ 156 ].…”

Section: Plant Extracts Mixturesmentioning

confidence: 99%

Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review

Massa

Pagliarello

Paolini³

et al. 2022

JCM

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Human papillomavirus (HPV) still represents an important threat to health worldwide. Better therapy in terms of further improvement of outcomes and attenuation of related side-effects is desirable. The pharmaceutical industry has always targeted natural substances—phytochemicals in particular—to identify lead compounds to be clinically validated and industrially produced as antiviral and anticancer drugs. In the field of HPV, numerous naturally occurring bioactives and dietary phytochemicals have been investigated as potentially valuable in vitro and in vivo. Interference with several pathways and improvement of the efficacy of chemotherapeutic agents have been demonstrated. Notably, some clinical trials have been conducted. Despite being endowed with general safety, these natural substances are in urgent need of further assessment to foresee their clinical exploitation. This review summarizes the basic research efforts conducted so far in the study of anti-HPV properties of bio-actives with insights into their mechanisms of action and highlights the variety of their natural origin in order to provide comprehensive mapping throughout the different sources. The clinical studies available are reported, as well, to highlight the need of uniformity and consistency of studies in the future to select those natural compounds that may be suited to clinical application.

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Section: Plant Extracts Mixturesmentioning

confidence: 99%

Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review

Massa

Pagliarello

Paolini³

et al. 2022

JCM

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“…Two botanical formulations called, respectively, “Basant”, made of purified curcumin and saponins mixed to Emblica officinalis and Aloe vera extracts and Mentha citrata oil [ 143 ], and “Praneem”, composed by purified saponins, extracts from Azadirachta indica, Emblica officinalis , and Aloe vera mixed to Mentha citrata oil, have been shown able to block transfer of HPV16 pseudovirions in HeLa cells [ 143 , 152 ].…”

Section: Plant Metabolites Targeting Hpv Tumorsmentioning

confidence: 99%

“…Subsequently, a phase I/II clinical trial demonstrated that intra-vaginal administration of either curcumin capsules or Basant cream in HPV-infected women (without high grade CIN), was able to induce higher infection clearance rate (87.7% for Basant cream, 81.3% for curcumin capsules) than untreated patients (73.3%) [ 172 ]. Basant administration cleared HPV16 infection in 100% of patients (i.e., 11 HPV-infected women with low grade cervical abnormalities) recruited in a more recent study [ 143 ].…”

Section: Plant Metabolites Targeting Hpv Tumorsmentioning

confidence: 99%

Plant-Derived Natural Compounds in Genetic Vaccination and Therapy for HPV-Associated Cancers

Franconi

Massa

Paolini³

et al. 2020

Cancers

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Antigen-specific immunotherapy and, in particular, DNA vaccination provides an established approach for tackling human papillomavirus (HPV) cancers at different stages. DNA vaccines are stable and have a cost-effective production. Their intrinsic low immunogenicity has been improved by several strategies with some success, including fusion of HPV antigens with plant gene sequences. Another approach for the control of HPV cancers is the use of natural immunomodulatory agents like those derived from plants, that are able to interfere in carcinogenesis by modulating many different cellular pathways and, in some instances, to reduce chemo- and radiotherapy resistance of tumors. Indeed, plant-derived compounds represent, in many cases, an abundantly available, cost-effective source of molecules that can be either harvested directly in nature or obtained from plant cell cultures. In this review, an overview of the most relevant data reported in literature on the use of plant natural compounds and genetic vaccines that include plant-derived sequences against HPV tumors is provided. The purpose is also to highlight the still under-explored potential of multimodal treatments implying DNA vaccination along with plant-derived agents.

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“…What was amazing was that every woman (11/11) who used BASANT for 30 nights, had no HPV-16 in their cervical cells. Pap smear, which was abnormal to begin with, became normal in each case [3]. Thus BASANT can be extremely helpful to women to get rid of infection of HPV-16 in their cervical cells at early stages of CIN I, II, so long as the virus is not integrated in the host genome.…”

Section: Anti-hiv Action Of Basantmentioning

confidence: 99%

Clinical Research Leading to Development of Two Products for Keeping Vagina Healthy and Preventing Sexually Transmitted Infections

2017

CRGO

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Described below are 2 Products developed by us which after undergoing successful clinical trials and approval of the Drugs Controller General of India (DCGI) and Institutional Ethics Committees, have been transferred to Industry for making these available to potential users. These are: [1] a Polyherbal formulation BASANT with inhibitory action on a wide spectrum of genital pathogens, and [2] 3 strains of Lactobacilli (Pro-vag-Health) that make and secrete high amounts of lactic acid, are hydrophobic to enable colonization and possess arginine deiminase, the enzyme preventing the formation of foul odour derivatives. The combined use of BASANT and pro-vag-Health in the Product NAUROZ, has the highest efficacy ever achieved for curing recurrent episodes of vaginosis.

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BASANT, a Polyherbal Safe Microbicide Eliminates HPV-16 in Women with Early Cervical Intraepithelial Lesions

Cited by 39 publications

References 7 publications

Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review

Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review

Plant-Derived Natural Compounds in Genetic Vaccination and Therapy for HPV-Associated Cancers

Clinical Research Leading to Development of Two Products for Keeping Vagina Healthy and Preventing Sexually Transmitted Infections

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