Basalzellkarzinome auf mit Radiotherapie vorbehandelten vaskulären Malformationen

Sattler, Eugen; Räwer, Henrik; Mühlstädt, Michael; Ruzícka, T.; Burgdorf, Walter H. C.; Kunte, Christian

doi:10.1007/s00105-011-2188-8

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…As with our patient, ultraviolet (UV) radiation is a known contributory factor in capillary malformation BCC development 1,2 . However, eight cases reported no prior radiation treatment, significant UV exposure or history of skin cancer 5 .…”

Section: Article Case Year Age Gender Site Affected Vm Type Prior V...supporting

confidence: 59%

“…Mohs or ablative lasers for BCC management and vascular malformation sclerotherapy have been suggested 1,2 . Laser therapy of capillary malformations may also enable earlier BCC identification and better outcomes 1,2 . It did lead to BCC identification within 12 months for our patient.…”

Section: Article Case Year Age Gender Site Affected Vm Type Prior V...mentioning

confidence: 85%

“…Identifying early BCC features against a background capillary malformation vascular pattern can be difficult 2 . This may lead to delayed diagnosis, when a lesion has become much larger 1,3 .…”

Section: Article Case Year Age Gender Site Affected Vm Type Prior V...mentioning

confidence: 99%

“…As most port‐wine stain occur on the head and neck, a site of increased BCC recurrence risk, this could pose difficulties for treatment 1,4 . Mohs or ablative lasers for BCC management and vascular malformation sclerotherapy have been suggested 1,2 . Laser therapy of capillary malformations may also enable earlier BCC identification and better outcomes 1,2 .…”

Section: Article Case Year Age Gender Site Affected Vm Type Prior V...mentioning

confidence: 99%

“…This suggests capillary malformations themselves may be a higher risk site for BCC development. A postulated mechanism is that increased capillary malformation vascularity, temperature and ectatic vessel changes from oncogenic factors result in the surrounding epidermis becoming more susceptible to radiation, including UV radiation 1,2 . Recent research revealing the role of pathways other than the well‐known hedgehog signalling pathway in BCC development may provide new insights.…”

Section: Article Case Year Age Gender Site Affected Vm Type Prior V...mentioning

confidence: 99%

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Capillary malformation as a locus minoris resistentiae for the development of basal cell carcinoma

Sideris¹,

Relic²

2021

Aust J Dermatology

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blood samples was positive. She was treated with benznidazole (5 mg/kg/day) for 30 days with total remission of lesions.A 62-year-old male presented with a 10-day history of a painful erythematous-brownish plaque on the left foot (Fig. 1c). Five months previously, he had received a heart transplant due to Chagas cardiomyopathy and was taking tacrolimus (6 mg), mycophenolate mofetil (360 mg) and prednisone (15 mg). A biopsy specimen showed lobular panniculitis with intracellular Trypanosoma cruzi amastigotes (Fig. 1g). Qualitative (PCR) assay for T. cruzi in blood samples was positive. He was treated with benznidazole (5 mg/kg/day) for 60 days with total clearance of the lesion.Reactivation of Chagas disease is a severe complication that can occur in solid organ transplant recipients. 1,2 Most cases are related to kidney or heart transplant, particularly in the first year post-transplant. 3 Liver recipients are at lower risk due to lower doses of immunosuppressants. 5 Indeed, we could not observe any sign of Chagas disease reactivation in our liver recipients, even in those with a diagnosis of chronic Chagas disease. It can manifest with high fever, cardiomyopathy, meningoencephalitis and several painful skin lesions. 2 Mild systemic symptoms were observed in only one patient (case 1); however, all of them developed painful panniculitis lesions.Diagnosis can be made through parasitaemia, histopathological exam, immunohistochemistry and/or PCR. 3,4 In our patients, the diagnosis was done through histopathological analysis, immunohistochemistry and qualitative PCR for T. cruzi in blood samples. Treatment can be nifurtimox or benznidazole. [1][2][3][4][5] Our patients showed good tolerability to benznidazole with remission of lesions.In endemic areas of Chagas disease such as Latin America, Chagas disease reactivation must be considered as an important diagnosis in solid organ transplant recipients, since it can cause graft rejection and death. It also should be kept in mind in developed regions such as the United States and Europe because of the immigrants from endemic areas.

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Section: Article Case Year Age Gender Site Affected Vm Type Prior V...supporting

confidence: 59%

Section: Article Case Year Age Gender Site Affected Vm Type Prior V...mentioning

confidence: 85%

Section: Article Case Year Age Gender Site Affected Vm Type Prior V...mentioning

confidence: 99%

Section: Article Case Year Age Gender Site Affected Vm Type Prior V...mentioning

confidence: 99%

Section: Article Case Year Age Gender Site Affected Vm Type Prior V...mentioning

confidence: 99%

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Capillary malformation as a locus minoris resistentiae for the development of basal cell carcinoma

Sideris¹,

Relic²

2021

Aust J Dermatology

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Malignant Skin Tumors in Children

Colmenero

McCarville

Reyes‐Múgica

2014

Pediatric Malignancies: Pathology and Imaging

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Analyzing the Genetic Spectrum of Vascular Anomalies with Overgrowth via Cancer Genomics

Siegel

Cottrell

Streicher

et al. 2018

Journal of Investigative Dermatology

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Vascular anomalies are variably associated with overgrowth, skeletal anomalies, and abnormalities of the brain, leptomeninges, and eye. We assembled a 16-institution network to determine the range of genetic variants associated with a spectrum of vascular anomalies with overgrowth, ranging from mild to severe. Because of the overlap between cancer-associated variants and previously described somatic variants in vascular overgrowth syndromes, we employed tumor genetic profiling via high-depth next-generation sequencing using a panel to assay affected tissue from a diverse cohort of subjects with vascular anomalies with overgrowth. Seventy-five percent (43/57) harbored pathogenic or likely pathogenic variants in 10 genes. We identified two genes (mTOR, PIK3R1) and several variants previously described in the setting of cancer but that, to our knowledge, have not been described in vascular malformations. All were identified at low variant allele frequency consistent with somatic mosaic etiology. By leveraging somatic variant detection technology typically applied to cancer in a cohort inclusive of broad phenotypic severity, we demonstrated that most vascular anomalies with overgrowth harbor postzygotic gain-of-function mutations in oncogenes. Furthermore, continued interrogation of oncogenes in benign developmental disorders could provide insight into fundamental mechanisms regulating cell growth.

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Basalzellkarzinome auf mit Radiotherapie vorbehandelten vaskulären Malformationen

Abstract: BCC overlying a port wine stain previously treated with radiation therapy is a rare but ideal indication for Mohs surgery. In addition we recommend regular clinical follow-ups to detect recurrent or additional BCC as early as possible.

Cited by 4 publications

References 29 publications

Capillary malformation as a locus minoris resistentiae for the development of basal cell carcinoma

Capillary malformation as a locus minoris resistentiae for the development of basal cell carcinoma

Malignant Skin Tumors in Children

Analyzing the Genetic Spectrum of Vascular Anomalies with Overgrowth via Cancer Genomics

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