Basaloid squamous cell carcinoma: a 31-year retrospective study and analysis of 214 cases reported in the literature

Schuch, Lauren Frenzel; Nóbrega, Kaio Heide Sampaio; Gomes, Ana Paula Neutzling; Vasconcelos, Ana Carolina Uchôa

doi:10.1007/s10006-020-00828-9

Cited by 8 publications

(7 citation statements)

References 19 publications

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“…Despite the gain in the reduction of risk factors, we witnessed the appearance, within four months, of a clinical picture with mild complaints but with a rare and very aggressive final diagnosis. This time-lapse for BSCC is in accordance with previous studies, as determined by Schuch and collaborators [5], that report a range evolution time of 3 to 12 months. Moreover, it is also described that the risk of tobaccorelated cancers of the upper aero-digestive tracts declines only five years after smoking cessation and may approach that of nonsmokers after 10 years of abstention [12].…”

Section: Discussionsupporting

confidence: 92%

“…More than 90% of all oral cancers are squamous cell carcinomas (SCC), being basaloid squamous cell carcinoma (BSCC) one of the rarest (0,6-0,8% of all SCC) and aggressive variant, usually detected at an advanced stage already with liver and/or lung metastases [3][4][5]. According to a total of 231 published BSCC cases, this variant has a predilection for the floor of the mouth (42,8%), tongue (19,1%), retromolar trigone (12,5%), and alveolar ridge/gingiva (11,8%), followed by the palate (6,6%) and buccal mucosa (5,9%), being rare in the tonsillar pillar (1,3%) [4][5]. In the 31-year retrospective study by Schuch and collaborators [5], the clinical presentation of BSCC was usually an asymptomatic ulcer with a mean evolution time of 6,8 months (range 3-12 months).…”

Section: Introductionmentioning

confidence: 99%

“…According to a total of 231 published BSCC cases, this variant has a predilection for the floor of the mouth (42,8%), tongue (19,1%), retromolar trigone (12,5%), and alveolar ridge/gingiva (11,8%), followed by the palate (6,6%) and buccal mucosa (5,9%), being rare in the tonsillar pillar (1,3%) [ 4 - 5 ]. In the 31-year retrospective study by Schuch and collaborators [ 5 ], the clinical presentation of BSCC was usually an asymptomatic ulcer with a mean evolution time of 6,8 months (range 3-12 months).…”

Section: Introductionmentioning

confidence: 99%

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Basaloid Squamous Cell Carcinoma, an Aggressive and Rare Cancer of the Oral Cavity: Can We Prevent It at the Primary Care Setting?

Cunha¹,

Sousa²,

Sousa³

2022

Cureus

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Oral cavity cancer represents about 2%-3% of all cancers worldwide, with more than 355,000 new cases per year, one-third of which are reported in developed countries. Oral cancer is also known to be extremely aggressive when detected late, thus presenting one of the lowest cancer survival rates. It is estimated that as much as 90% of oral cancers are attributable to tobacco and/or alcohol consumption and that high-risk human papillomaviruses (HPV) infections pose an independently increased risk for their development. Therefore, it can be a preventable disease when associated with changes in lifestyle and possible modifiable risk factors, combined with early and preventive intervention.Basaloid squamous cell carcinoma (BSCC) constitutes an aggressive and rare form of oral cancer, being one of the rarest and most aggressive variants of squamous cell carcinoma (SCC, the most common), and usually presents as a high-grade disease with a poor prognosis. It is typically associated with heavy smoking and alcohol abuse, occurring most commonly in older men.Here, we report a clinical case of a 60-year-old man with excessive consumption of both tobacco and alcohol, poor oral hygiene, and partial edentulousness who came to our primary health department with complaints of odynophagia twice in a four-year time-lapse. The first time, two whitish ulcerated lesions on the left tonsil were detected and biopsied but revealed a negative histological result. After four years, he came again to our primary health care department with similar complaints of odynophagia and also sore throat with radiation to the right ear, accompanied by globus sensation and anorexia. No suspicious lesions were detected, except a globally hyperemic oropharynx. Considering the history of abusive consumption, no improvement with symptomatic treatment, and persistent clinical signs, an extended diagnostic approach was carried out. After four months, a pharyngeal mass measuring 53 mm was detected on pharyngeal-neck computed tomography (CT), and the diagnosis of a BSCC located in the right tonsillar pillar and base of the tongue was finally determined.Unlike other cancers that have been detected earlier through screening programs, oral cancer is often detected at an advanced stage, compromising survival and quality of life. The opportunity to intervene early and preventively in consumption habits, promote healthy lifestyles, and try to prevent disease is unique at the primary care level. Moreover, opportunistic screening through a thorough examination of the oral cavity is extremely important for timely diagnosis and treatment.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Basaloid Squamous Cell Carcinoma, an Aggressive and Rare Cancer of the Oral Cavity: Can We Prevent It at the Primary Care Setting?

Cunha¹,

Sousa²,

Sousa³

2022

Cureus

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“…The clinicopathological characteristics of oral BSCC (OBSCC) are poorly understood because it is extremely rare. Most published studies include only case reports, and there are only a few reviews described alone about OBSCC 3‐5 . Based on the therapeutic experience of BSCC arising in the floor of the mouth, we reviewed the cases of OBSCC reported in Japan to reveal its pathophysiology in this study.…”

Section: Introductionmentioning

confidence: 99%

Basaloid squamous cell carcinoma of the floor of the mouth: A case report with review of the literature

Kim

Yagihara

Yagishita

et al. 2021

Oral Science International

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We present the case of a 66-year-old man with basaloid squamous cell carcinoma (BSCC) of the floor of the mouth, which is extremely rare. The patient underwent wide resection of the tumor with partial mandibulectomy and neck dissection. The immunohistochemical staining of surgical specimen showed the p16 positivity, and the examination for human papillomavirus was performed. The patient was followed up for 2 years without any evidence of disease. To address the pathophysiological features of oral BSCC, we reviewed the literature and revealed that the number of early stage cases and the survival rate were higher than in previous reports.

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“…Diversos estudos têm mostrado que o carcinoma escamoso basalóide apresenta elevadas taxas de metástases regional e à distância, sugerindo um perfil clínico mais agressivo quando comparado ao carcinoma espinocelular convencional de boca (SAMPAIO-GÓES et al, 2005;FRITSCH;LENTSCH, 2014;HANEMANN et al, 2014;SCHUCH et al, 2020).…”

Section: Introductionunclassified

Imunoexpressão de marcadores de células-tronco tumorais em subtipos de carcinomas espinocelulares de boca

Filho¹

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AGRADECIMENTOSA Deus, em sua infinita bondade, por ter tido a oportunidade de concluir este estudo e ter concretizado uma etapa significativa da minha formação profissional e pessoal. A minha orientadora, Professora Dra. Denise Tostes Oliveira, pela oportunidade ímpar, acolhimento e generosidade intelectual. Gratidão pela imensa contribuição para que eu pudesse amadurecer cientificamente e profissionalmente, motivando e desafiando para analisar com crítica e enxergar com perspicácia. Meus sinceros agradecimentos pelos conselhos, conversas e incentivos! Aos meus pais, Eliene Regina Martins e Silas Antonio Juvencio de Freitas, por estarem presentes mesmo na distância, pelo apoio em minhas escolhas e aconselhamentos para escolher sempre os bons caminhos! Amo vocês! A Ludimila Lemes Moura, minha companheira, obrigado pela colaboração, apoio, dedicação e suporte nos momentos desafiadores desta jornada. Aos meus irmãos, Miguel de Freitas Neto e Rafael Martins de Freitas, e minha querida sobrinha, Helena Costa Freitas, obrigado por sorrirem comigo e pelo carinho durante esta etapa. A Bethânia Martins Silva, Gabriely Martins Silva e Stephanie Wutke Oliveira, pela amizade, apoio e motivação para a concretização deste sonho. Aos meus avós, tios e tias, por serem exemplos de força, persistência e perseverança. Agradeço em especial a Natália Galvão Garcia, pela hospitalidade, amizade, ensinamentos e por estender a mão em diversos momentos. Aos colegas de pós-graduação, Agnes Assao, Alexandre Simões Garcia e Talita Nery, pelo companheirismo, trocas de experiências e colaboração em diversos momentos destes anos. Aos professores da área de Patologia da FOB-USP, Prof.

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Basaloid squamous cell carcinoma: a 31-year retrospective study and analysis of 214 cases reported in the literature

Cited by 8 publications

References 19 publications

Basaloid Squamous Cell Carcinoma, an Aggressive and Rare Cancer of the Oral Cavity: Can We Prevent It at the Primary Care Setting?

Basaloid Squamous Cell Carcinoma, an Aggressive and Rare Cancer of the Oral Cavity: Can We Prevent It at the Primary Care Setting?

Basaloid squamous cell carcinoma of the floor of the mouth: A case report with review of the literature

Imunoexpressão de marcadores de células-tronco tumorais em subtipos de carcinomas espinocelulares de boca

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