Basaloid carcinoma of the thymus

Kawashima, Osamu; Kamiyoshihara, Mitsuhiro; Sakata, Satoko; Kurihara, Terumasa; Ishikawa, Susumu; Morishita, Yasuo

doi:10.1016/s0003-4975(99)01063-2

Cited by 22 publications

(16 citation statements)

References 6 publications

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“…Univariate survival analyses were performed using the Kaplan-Meier method and the log-rank test. When disease-specific survival was considered, BC subjects had a shorter survival than non-BC (log rank p50.014) and [1][2][3][4][5][6]. However, due to the distinction in the WHO classification of lung tumours of two basaloid variants belonging either to the SCC group or to the LCC group, diagnosis of lung carcinomas with a basaloid pattern remains a difficult area for pathologists.…”

Section: Discussionmentioning

confidence: 99%

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Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis

Moro-Sibilot¹,

Lantuéjoul²,

Diab³

et al. 2008

European Respiratory Journal

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Lung carcinoma with a basaloid pattern (BC) is classified as either a basaloid variant of squamous cell carcinoma (SCC) or as variant of large cell carcinoma (LCC) depending on the presence of a squamous component. In a previous study of 37 cases, the present authors showed that BC presented with a shorter median and overall survival.In order to confirm its clinical significance in a larger series, 90 BC, including 46 basaloid variants of LCC and 44 basaloid variants of SCC, were compared with 1,328 other nonsmall cell lung carcinoma (NSCLC) with regard to clinical features and survival.The survival of basaloid variants of LCC and SCC was comparable. Median and overall survival were significantly lower for BC than for NSCLC in stage I-II patients, with a median survival of 29 and 49 months, respectively, and 5-yr survival rates of 27 and 44% for BC and NSCLC. When disease-specific survival was considered, BC had a shorter survival than both NSCLC and SCC.Basaloid pattern confers a poor prognosis in nonsmall cell lung carcinoma, especially in stage I-II patients, suggesting that lung carcinoma with a basaloid pattern is not only a variant of squamous cell carcinoma or large cell carcinoma, but is a unique entity with a significantly poor prognosis.

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Section: Discussionmentioning

confidence: 99%

“…uring the last 20 yrs, basaloid carcinomas have been identified in organs other than the lungs as aggressive tumours with a poor prognosis [1][2][3][4][5][6][7]. In 1992, the current authors first reported this entity in the lung and described its clinicopathological features in a founding paper based on the observation of 37 basaloid carcinomas [1].…”

mentioning

confidence: 99%

Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis

Moro-Sibilot¹,

Lantuéjoul²,

Diab³

et al. 2008

European Respiratory Journal

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“…We found only three documented cases in our hospital files over a period of 15 yr. Only eleven other BTCs have been previously reported in the surgical pathology literature as part of a series or as case reports (Table II). [3][4][5][6][7][8][9] The mean age of presentation is 62 yr, including our current cases. 7 The male-to-female ratio is 8:5.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9] The mean age of presentation is 62 yr, including our current cases. 7 The male-to-female ratio is 8:5. 8 An associated thymic cyst is present in 11 of 14 cases, including two of our current cases.…”

Section: Discussionmentioning

confidence: 99%

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Fine‐needle aspiration cytology of thymic basaloid carcinoma: Case studies and review of the literature

Posligua¹,

Ylagan²

2006

Diagnostic Cytopathology

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We report the features in fine-needle aspiration biopsy (FNAB) of thymic basaloid carcinomas. This is a rare neoplasm, of which there are only three documented in our hospital files. To the best of our knowledge, this is the first fine-needle aspiration (FNA) report on basaloid carcinoma of the thymus. This is a tumor in which the FNA diagnosis is difficult and the differential diagnosis is broad. We describe the cytologic features encountered in the three cases, and immunohistochemical and ultrastructural findings so as to raise awareness of this entity in the differential diagnosis of thymic neoplasms on FNABs. The cases studied included three male patients, aged 73, 65, and 50, who presented with anterior mediastinal masses, with no primary tumor elsewhere. FNAB was performed on two cases, followed by thymectomy. One case, additionally, had metastasis to a cervical lymph node, and the other two were associated with thymic cysts. The diagnoses on all three cases were thymic basaloid carcinoma.

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