Basaloid carcinoma of the colon arising at the splenic flexure

Newell, Ken J.; Penswick, John L.; Driman, David K.

doi:10.1046/j.1365-2559.2001.01080.x

Cited by 16 publications

(22 citation statements)

References 9 publications

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“…[7][8][9][10][11][12][13][14][15] Some of these histological types are associated with a worse prognosis than that of conventional adenocarcinoma. [16][17][18][19] To the best of our knowledge, there has only been one previously published report of micropapillary colorectal carcinoma by Kim et al 6 with a series from South Korea.…”

Section: Discussionmentioning

confidence: 99%

Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis

Haupt

Schwartz

et al. 2007

Modern Pathology

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Micropapillary carcinoma has been reported as an aggressive variant of carcinoma in several organs, where it is associated with frequent lymphovascular invasion and poor clinical outcome. This study explored the clinicopathological features of colorectal adenocarcinoma with a micropapillary carcinoma component and compared them with those of conventional colorectal adenocarcinoma. One hundred seventy-eight consecutive cases of surgically resected colorectal carcinomas were studied for tumor size, type, depth of invasion, nodal and distant metastases, tumor stage, and percentage and extent of micropapillary component. Among 178 cases of colorectal carcinoma, 34 (19.1%) cases had a micropapillary component, which ranged from 5 to 60% of the entire tumor. Lymph node metastasis was identified in 25 of 34 (73.5%) carcinomas with micropapillary component, whereas they were detected in 61 of 144 (42.4%) cases without micropapillary component (P ¼ 0.001). Lymphovascular invasion was identified more frequently in carcinoma with micropapillary component (41.2%) than carcinoma without micropapillary component (20.1%; Po0.05). Distant metastases occurred in 4 of 34 cases (11.7%) with micropapillary component and in 10 of 144 cases (6.9%) without micropapillary component (P ¼ 0.311). Multivariate regression analysis demonstrated that the presence of micropapillary component, as well as tumor stage and lymphovascular invasion are independent predictors of regional nodal metastasis.

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Section: Discussionmentioning

confidence: 99%

Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis

Haupt

Schwartz

et al. 2007

Modern Pathology

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“…KJ Newell, J L Penswick and DK Driman states that basaloid carcinoma is the common neoplasm of the anorectal region. 11 In our study, there was only one case of carcinoid comprising of 0.46% of all microscopic types. Cullen PK states that 5 to 10% of carcinoid was located in the colon, with the majority occurring in the caecum.…”

Section: Sitementioning

confidence: 46%

A Clinicopathological Correlation of Colorectal and Anal Canal Malignancy

Kantilal¹,

Haria²,

Dahake³

et al. 2015

jemds

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BACKGROUND:Colorectal carcinoma is considered a calamity for humanity, but it could have a long survival if it is diagnosed early. The epidemiology of this calamity is also interesting and has always been the subject of investigation in the in the western world. AIMS: 1.To compare the findings in a series of 215 cases studied over a period of 6 years from 2008 to 2013. 2. To study the incidence of colorectal carcinoma in a population with respect to age, sex, religion and diet. 3. To study the occurrence of the carcinoma in a different parts of the colon. 4. To study the different histological and morphological types of carcinoma of colon. 5. To study the stages of carcinoma at the time of presentation by American Joint Commission on Cancer (AJCC) staging system. 6. To study the clinical presentation of colorectal carcinoma. SETTINGS: Lokmanya Tilak Municipal General Hospital, Sion, Mumbai. DESIGN: A retrospective observational study. METHODS AND MATERIAL: The malignant tumor of large bowel and anal canal received in the Surgical Pathology, Department of Pathology, Lokmanya Tilak Medical College and General Hospital in Mumbai in the form of biopsy and resected speciemen were studied after microscopic confirmation of diagnosis over a period of 6 years from 2008 to 2013. A total number of cases studied are 215 cases excluding the superficial biopsy and doubtful cases. RESULTS: Of total 46255 surgical specimen, 6911 were gastrointestinal specimen i.e. 14.9% of all specimens, and 4271 were colorectal specimen. Of 4271 gastrointestinal specimens 497 gastrointestinal malignancy while 215 had colorectal malignancy. The common age group affected is 51-60 years. Rectum (57.74%) is the most common site of colorectal malignancy. Abdominal pain (33.5%) was the most common clinical feature. Ulceroinfilterative is the most common type of gross morphology of tumor in rectum. Hindu and non-vegetarian are most common risk factors. Adenocarcinoma (52.55%) was the most common microscopic type, belonging to AJCC stage IIA (40%). CONCLUSION: The most common site for gastrointestinal malignancy was rectum and anal canal with adenocarcinoma was the most common microscopic type. The above observation implies for a greater emphasis on early recognition of signs and symptoms, to facilitate for early diagnosis so that curative resection can be attempted for the patient to enjoy a better prognosis and better quality of life.

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“…As regards the basaloid variety of squamous cell carcinoma outside the anal canal, it may arise from cloaco- genic embryologic nests, squamous metaplastic epithelium, or totipotential basal cells [12]. In mixed adenosquamous variety, Cerezo and others suggested that all such lesions be carefully evaluated by means of immunoperoxidase stains and/or electron microscopy in order to identify squamous features [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Historically, this rare histologic subtype of squamous cancer has been diagnosed in 3 patients with colorectal tumors, none more proximally than the splenic flexure [12]. Herein we present a case of a basaloid carcinoma of the rectum outside the anal canal, with a comprehensive review of the literature and a clarification of the clinicopathologic features of this rare entity.…”

Section: Introductionmentioning

confidence: 91%

Basaloid Squamous Cell Carcinoma of the Rectum: A Rare Entity

Machairas

2013

J Med Cases

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We report a case of a 33-year old woman with a squamous-cell carcinoma of the rectum, of the basaloid subtype, infiltrating the uterus. The pathologic data and imaging findings that document the presence of the primary tumor of the rectum are presented in detail. Basaloid tumor is a histologic subtype of squamous-cell carcinoma arising usually in the anal canal. In this article we present a case of basaloid carcinoma of the rectum outside the anal canal with a bibliographical review of this rare clinical entity.

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Basaloid carcinoma of the colon arising at the splenic flexure

Cited by 16 publications

References 9 publications

Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis

Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasis

A Clinicopathological Correlation of Colorectal and Anal Canal Malignancy

Basaloid Squamous Cell Carcinoma of the Rectum: A Rare Entity

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