Basal testosterone concentrations after the application of a slow-release GnRH agonist implant are associated with a loss of response to buserelin, a short-term GnRH agonist, in the tom cat

Goericke-Pesch, Sandra; Georgiev, Plamen; Fasulkov, Ivan; Vodenicharov, A.; Wehrend, Axel

doi:10.1016/j.theriogenology.2013.03.010

Cited by 19 publications

(32 citation statements)

References 12 publications

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“…The efficacy of Suprelorin in cats is therefore documented through the use of indirect markers including testosterone, progesterone or estradiol concentrations. 5,11,17,22 …”

Section: Evidence Basementioning

confidence: 99%

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Long-term contraception in a small implant

Fontaine

2015

Journal of Feline Medicine and Surgery

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Rationale:Deslorelin (Suprelorin®; Virbac) is a gonadotropin-releasing hormone (GnRH) agonist licensed in select countries for the long-term suppression of fertility in adult male dogs and male ferrets. This article summarizes studies investigating the use of deslorelin implants for the long-term suppression of fertility in male and female domestic cats.Evidence base:Slow-release deslorelin implants have been shown to generate effective, safe and reversible long-term contraception in male and female cats. In pubertal cats, a 4.7 mg deslorelin implant suppressed steroid sex hormones for an average of approximately 20 months (range 15–25 months) in males and an average of approximately 24 months (range 16–37 months) in females. Reversibility has been demonstrated by fertile matings approximately 2 years post-treatment in both male and female adult cats. In prepubertal female cats of approximately 4 months of age, puberty was postponed to an average of approximately 10 months of age (range 6–15 months) by a 4.7 mg deslorelin implant.Challenges:The large variability in the duration of suppression of gonadal activity makes the definition of the optimal time for reimplantation quite challenging. In addition, the temporary stimulation phase occurring in the weeks following deslorelin implantation can induce in adult female cats a fertile estrus that needs to be managed to avoid unwanted pregnancy. Longer duration and larger scale controlled field studies implementing blinding, a negative control group and a carefully controlled randomization to each group are needed. Furthermore, the effects of repeated treatment need to be investigated. Finally, the effect of treatment on growth and bone quality of prepubertal cats needs to be assessed. However, the ease of use, long-lasting effects and reversibility of deslorelin implants are strong positive points supporting their use for controlling feline reproduction.

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“…The efficacy of Suprelorin in cats is therefore documented through the use of indirect markers including testosterone, progesterone or estradiol concentrations. 5,11,17,22 …”

Section: Evidence Basementioning

confidence: 99%

“…13,14 In one additional experimental study of five adult male cats, the age of the animals was not reported. 22 …”

Section: Evidence Basementioning

confidence: 99%

Long-term contraception in a small implant

Fontaine

2015

Journal of Feline Medicine and Surgery

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“…In contrast to the male dog, the effects on spermatogenesis were also quite variable (Goericke‐Pesch et al. , , ; Novotny et al. ) with an arrest of spermatogenesis on all levels possible (spermatogonia, spermatocytes, round or elongating spermatids), or also fully elongated spermatids being observed in some animals (Novotny et al.…”

Section: Slow‐release Gnrh‐agonist Implantsmentioning

confidence: 99%

“…Except for slight local reactions at the application site, no treatment‐related side effects were reported (Goericke‐Pesch et al. , , ; Toydemir et al. ).…”

Section: Use In the Adult Queenmentioning

confidence: 99%

Suppression of Fertility in Adult Cats

Goericke-Pesch

Wehrend

Georgiev

2014

Reprod Domestic Animals

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Contents Cats are animals with highly efficient reproduction, clearly pointing to a need for suppression of fertility. Although surgical contraception is highly effective, it is not always the method of choice. This is predominantly because it is cost‐intensive, time‐consuming and irreversible, with the latter being of major importance for cat breeders. This article reviews the use of progestins, scleroting agents, immunocontraception, melatonin, GnRH antagonists and finally, GnRH agonists, in adult male and female cats in detail, according to the present state of the art. By now, various scientific and clinical options are available for the suppression of fertility in adult cats and the decision as to which should be chosen – independent of the legal registration of any state – depends on different facts: (i) feral or privately owned animal? (ii) temporary or permanent suppression of fertility wanted/needed? (iii) sex of the animal? New effective and available methods for hormonal contraception include melatonin implants for short‐term post ponement of oestrus in adult queens and slow‐release GnRH‐agonist implants containing deslorelin (Suprelorin®) for short‐ and long‐term contraception in male and female companion and breeding cats.

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“…Although the available product containing deslorelin is licensed for the temporary suppression of fertility in adult and intact male dogs and male ferrets only (Ema, 2012) and all above described effects are well-known to occur (Trigg et al, 2001;Junaidi et al, 2003Junaidi et al, , 2007Junaidi et al, , 2009aSchoemaker et al, 2008;Romagnoli et al, 2012;Van Zeeland et al, 2014). Offlabel use of sustained released GnRH agonist implants has been effective for temporary hormonal castration in tom cats (Goericke-Pesch et al, 2011a, 2013b, 2014Novotny et al, 2012), boars (Kauffold et al, 2010), and also in model animals such as rats (Grosset et al, 2012;Edwards et al, 2013) or (captive) wildlife animals such as coyotes (Mac Gregor et al, 2013), red pandas (Koeppel et al, 2014), sea otters (Larson et al, 2013) and cheetahs (Bertschinger et al, 2006).…”

Section: Introductionmentioning

confidence: 99%