Basal plasma concentration of tissue plasminogen activator (t-PA) and the adaption to strenuous exercise in familial hypercholesterolaemia (FH)

Hansen, John‐Bjarne; Svensson, B.; Zhang, C.-L.; Lyngmo, V.; Nordøy, Arne

doi:10.1097/00001721-199410000-00016

Cited by 13 publications

(7 citation statements)

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“…However, the evidence reported from longitudinal studies is conflicting and suggests that physical conditioning programmes may reduce plasma fibrinogen level in patients and elderly individuals, but not in the young or middleaged. [59] …”

Section: Blood Coagulationmentioning

confidence: 99%

Effects of Exercise on Blood Coagulation, Fibrinolysis and Platelet Aggregation

Elsayed

1996

Sports Medicine

143

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Disturbances of the haemostatic balance may result in thrombosis or bleeding tendency. There have been abundant reports on the effects of exercise on blood haemostasis, but the results reported have been conflicting and difficult to interpret. This review outlines and critically evaluates the relevant literature on the effects of short term exercise and physical training on the 3 systems of blood haemostasis i.e. blood coagulation, fibrinolysis and platelet aggregation. Short term exercise is usually associated with a significant shortening of activated partial thromboplastin time (APTT) and a marked increase in factor VIII (FVIII). The rise in FVIII is directly related to exercise intensity and the individuals' training status. Exercise also induces a significant increase in blood fibrinolysis which is dependent on exercise intensity, duration and training condition. The rise in blood fibrinolysis is mainly due to an increase in tissue-type plasminogen activator (t-PA) and a decrease in its main inhibitor plasminogen activator inhibitor (PAI-1) which are released from the endothelial cells of the vessel wall. Platelet count increases in exercise and this is probably due to a fresh release of platelets from the spleen, bone marrow and lungs. Studies on the effects of exercise on platelet aggregation and markers of platelet activation have produced conflicting results, and the exact effects of exercise remain as yet undetermined. It is suggested that short term exercise activates blood coagulation and enhances blood fibrinolysis and the delicate balance between clot formation and clot dissolution is maintained in normal populations. No valid conclusion could be reached regarding the actual effects of physical training on blood coagulation, fibrinolysis and platelet aggregation. This is undoubtedly due to variations in training programmes employed, populations studied, and the analytical methods used.

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Section: Blood Coagulationmentioning

confidence: 99%

Effects of Exercise on Blood Coagulation, Fibrinolysis and Platelet Aggregation

Elsayed

1996

Sports Medicine

143

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“…38 tPA activity was determined according to Wiman et al 39 as previously described. 40 Plasma fibrinogen was measured with an ACL 3000 Coagulation System manufactured by Instrumentation Laboratory SpA.…”

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confidence: 99%

Insulin Resistance in Hypertension Is Associated With Body Fat Rather Than Blood Pressure

1998

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Abstract-The insulin resistance syndrome has been characterized by hypertension, upper body obesity, insulin resistance, hyperinsulinemia, glucose intolerance, and hypertriglyceridemia. Previous studies are inconsistent regarding the relationship between blood pressure and insulin resistance. We therefore compared the metabolic profile in 60 hypertensive subjects (meanϮSD arterial pressure, 116Ϯ7 mm Hg) and 60 normotensive subjects (mean arterial pressure, 88Ϯ5 mm Hg) matched for age, gender, and body mass index. Hypertensives had significantly higher waist-to-hip ratio than normotensives (Pϭ0.002). The groups did not differ in fasting plasma glucose, and suppression of nonesterified fatty acids during a hyperglycemic clamp (1%, Pϭ0.40). There were significant differences in fasting levels of C-peptide (50 pmol/L, Pϭ0.004) and proinsulin (2 pmol/L, Pϭ0.01), 2-hour postload levels of glucose (0.8 mmol/L, Pϭ0.01) and insulin (84 pmol/L, Pϭ0.01) after oral glucose challenge, and hepatic glucose production during the clamp (2.87 mol ⅐ kg Ϫ1 ⅐ min Ϫ1 , Pϭ0.02). These differences were not significant when controlling for waist-to-hip ratio. Body mass index and waist-to-hip ratio were similarly associated with the insulin sensitivity index in the hypertensive (rϭϪ0. 59, Pϭ0.0001 and rϭϪ0.32, Pϭ0.05) and normotensive (rϭϪ0.58, Pϭ0.0001 and rϭϪ0.39, Pϭ0.05) groups. Hypertension per se is not associated with insulin resistance. However, even small increments in both body mass index and waist-to-hip ratio, as often seen in hypertension, may lead to impairment in insulin sensitivity, probably mediated through altered lipid metabolism. (Hypertension. 1998;32:115-122.)

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“…The plasma concentration of tPA is 70 pM, and it has a half-life of 4 minutes, so it is tightly regulated [68, 84]. Unlike other serine proteases like uPA and plasmin, the single chain of tPA (sc-tPA) has inherent catalytic activity and can activate plasminogen [85]; however, cleavage of the R275-I276 bond by plasmin and conversion to two-chain tPA (tc-tPA) increases plasminogen activation rates from 3- to 10-fold in the absence of fibrin [34, 40].…”

Section: Fibrinolytic Agents: Activation and Inhibitionmentioning

confidence: 99%

Biophysical Mechanisms Mediating Fibrin Fiber Lysis

Hudson

2017

BioMed Research International

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The formation and dissolution of blood clots is both a biochemical and a biomechanical process. While much of the chemistry has been worked out for both processes, the influence of biophysical properties is less well understood. This review considers the impact of several structural and mechanical parameters on lytic rates of fibrin fibers. The influences of fiber and network architecture, fiber strain, FXIIIa cross-linking, and particle transport phenomena will be assessed. The importance of the mechanical aspects of fibrinolysis is emphasized, and future research avenues are discussed.

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Basal plasma concentration of tissue plasminogen activator (t-PA) and the adaption to strenuous exercise in familial hypercholesterolaemia (FH)

Cited by 13 publications

References 0 publications

Effects of Exercise on Blood Coagulation, Fibrinolysis and Platelet Aggregation

Effects of Exercise on Blood Coagulation, Fibrinolysis and Platelet Aggregation

Insulin Resistance in Hypertension Is Associated With Body Fat Rather Than Blood Pressure

Biophysical Mechanisms Mediating Fibrin Fiber Lysis

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