Basal Metabolic Rate and Thyroid Hormones

Tata, Jamshed R.

doi:10.1016/b978-1-4831-6748-0.50010-0

Cited by 24 publications

(11 citation statements)

References 140 publications

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“…In a previous study Buccino (34). In the present investigation in order to focus on energy utilization, the process of energy production was specifically inhibited, and therefore no information relative to energy production is available.…”

Section: Discussionmentioning

confidence: 90%

Mechanochemistry of cardiac muscle

Skelton¹,

Pool²,

Seagren³

et al. 1971

J. Clin. Invest.

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A B S T R A C T The possibility that alterations in the rate or efficiency of energy utilization could be involved in the control of cellular oxygen consumption by thyroid hormone was examined in right ventricular papillary muscles isolated from normal euthyroid cats and cats with experimentally induced hyperthyroidism and hypothyroidism. Energy production in the muscles was inhibited and isolated from the process of energy utilization by exposure to iodoacetic acid and nitrogen. After resting or performing variable amounts of contractile element work under isometric conditions, muscles were frozen, and the total amount of chemical energy (~P = creatine phosphate + ATP) used was determined. The resting rate of energy utilization in muscles from euthyroid animals was 0.78 ±0.07 tmoles/g per min of P.This rate was elevated in muscles from hyperthyroid cats to 1.00 ±0.09 gmoles/g per min and decreased in muscles from hypothyroid cats to 0.23 ±0.14 umoles/g per min. Isometrically contracting muscles from cats with hypothyroidism utilized only 64% as much energy as muscles from euthyroid cats while performing 81% as much contractile element work at a moderately decreased level of contractile state. Muscles from hyperthyroid cats utilized an average of 41% more energy than did muscles from euthyroid cats while contracting an identical number of times and performing an equal amount of contractile element work at a slightly increased level of contractile state. These results suggest that thyroid hormone directly influences the rate of cellular energy utilization. Furthermore, the increase in energy utilization in muscles from hyperthyroid cats could not be attributed entirely to observed alterations in contractile behavior, which indicates that excess thyroid hormone may decrease the efficiency of the conversion of cellular energy to work. However, the opposite effect, an increased efficiency of energy utilization, was not observed in muscles from hypothyroid cats. Thus, it is concluded that the calorigenic effects of thyroid hormone may be explained, at least in part, by alterations in the process of energy utilization. INTRODUCTIONThyroid hormone has many effects on cellular function, the most striking of which is its influence on oxygen consumption or energy metabolism. The stimulation of oxygen consumption found in most tissues after the administration of thyroid hormone has been attributed to changes in the rate of energy generation, the efficiency of energy generation, or a combination of these (1). The chief features of clinical and experimental hyperthyroidism and hypothyroidism have been postulated to result from changes in the process of energy generation (2), shown schematically in Fig. 1 as Coupling A. However, it is also possible that a change in the rate or efficiency of energy utilization, Coupling B,

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Section: Discussionmentioning

confidence: 90%

Mechanochemistry of cardiac muscle

Skelton¹,

Pool²,

Seagren³

et al. 1971

J. Clin. Invest.

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“…In some cases, the metabolic and growth-promoting effects may be different manifestations of the same fundamental action of a hormone. For example, the regulation of basal metabolic rate by thyroid hormones under physiological conditions is a relatively slow process and can be rationalized in the same biochemical terms as their growth and developmental actions, namely, the ability to modulate overall protein synthesis (Pitt-Rivers and Tata, 1959;Tata, 1964aTata, ,b, 1966a. In contrast, prolactin has very different actions in mammalian and nonmammalian vertebrates (Nicoll and Bern, 1972;Clarke and Bern, 1980), as we shall see later (Section 3.2.1, Fig.…”

Section: Classification Of Hormonesmentioning

confidence: 84%

“…The findings with thyroid hormones were particularly illuminating, since they were thought to act predominantly via control of oxidative phosphorylation or of individual enzymes involved in energy metabolism (Tata, 1964a). One now had to consider that the regulation of basal metabolic rate in mammals involved more global changes in the synthesis of several mitochondrial and extramitochondrial enzymes.…”

Section: Action Of Growth and Developmental Hormones: General Considementioning

confidence: 99%

The Action of Growth and Developmental Hormones

Tata

1984

Biological Regulation and Development

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“…It has been known for a very long time that defective functioning of the thyroid or total atrophy of the gland lead to a marked reduction in rate of growth (Fagge, 1871), but it has not before been so clearly apparent that hyperactivity of the thyroid also leads to a diminished rate of growth. In hyperthyroidism when the metabolic rate is considerably increased (Tata, 1964), the utilization of dietary energy is appreciably less efficient. In these experiments in which a lowered rate of growth has also been observed it is possible that the appetites of these animals did not keep pace with the increased metabolic requirements in order to maintain the highest rates of growth.…”

Section: Resultsmentioning

confidence: 99%

Thyroid activity and growth rate in rapidly growing lambs

Draper¹,

Falconer²,

Ge³

1968

The Journal of Physiology

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SUMMARY1. This paper reports a study of the relationship between thyroid gland activity and rate of growth of lambs held in a controlled environment with feeding ad libitum.2. Thyroid activity was assessed by the rate of release of 131I from the thyroid gland over a period of 1-2 weeks following injection. Growth rates were simultaneously recorded on a total of thirty-one lambs during forty-six measurements of thyroid activity.3. The results demonstrated a highly significant curvilinear correlation between growth rate and the rate constant for thyroid 131I release (P < 0.001).4. Surgically thyroidectomized animals were demonstrated to have a much reduced rate of growth.5. It was concluded that thyroid activities considerably above or below the optimum have an adverse effect on growth rate.

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Basal Metabolic Rate and Thyroid Hormones

Cited by 24 publications

References 140 publications

Mechanochemistry of cardiac muscle

Mechanochemistry of cardiac muscle

The Action of Growth and Developmental Hormones

Thyroid activity and growth rate in rapidly growing lambs

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