Basal Metabolic Rate and Serum Protein‐bound Iodine in Thyroid Disturbances with Special Reference to Goitre and “Hypometabolism”

In birds and mammals, the thyroid gland secretes the iodothyronine hormones of which tetraiodothyronine (T4) is less active than triiodothyronine (T3). The action of T3 and T4 is calorigenic and is involved in the control of metabolic rate. Across all vertebrates, thyroid hormones also play a major role in differentiation, development and growth. Although the fish thyroidal system has been researched extensively, its role in thermogenesis is unclear. In this study, we measured overall heat production to an accuracy of 0.1 mW by direct calorimetry in a free-moving European eel (Anguilla anguilla L.) with different thyroid status. Hyperthyroidism was induced by injection of T3 and T4, and hypothyroidism was induced with phenylthiourea. The results show for the first time at the organismal level, using direct calorimetry, that neither overall heat production nor overall oxygen consumption in eels is affected by hyperthyroidism. Therefore, we conclude that the thermogenic metabolism-stimulating effect of thyroid hormones (TH) is not present with a cold-blooded fish species like the European eel. This supports the concept that TH does not stimulate thermogenesis in poikilothermic species.

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Direct calorimetry of free-moving eels with manipulated thyroid status

Ginneken

Ballieux

Antonissen

et al. 2006

Naturwissenschaften

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On commonness and rarity of thyroid hormone resistance: A discussion based on mechanisms of reduced sensitivity in peripheral tissues

Tjørve¹,

Tjørve²,

Olsen³

et al. 2007

Medical Hypotheses

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The Syndromes of Obesity and of Delayed Growth in Adolescence

Hortling

Chapelle

Frisk

et al. 1964

Journal of Internal Medicine

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Basal Metabolic Rate and Serum Protein‐bound Iodine in Thyroid Disturbances with Special Reference to Goitre and “Hypometabolism”

Cited by 3 publications

References 18 publications

Direct calorimetry of free-moving eels with manipulated thyroid status

Direct calorimetry of free-moving eels with manipulated thyroid status

On commonness and rarity of thyroid hormone resistance: A discussion based on mechanisms of reduced sensitivity in peripheral tissues

The Syndromes of Obesity and of Delayed Growth in Adolescence

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