Basal Lamina of the Dermal Capillary: Concentric Multilamination Following Regeneration Processes

Imayama, Shuhei; Ikawa, Tomoko; Urabe, Harukuni

doi:10.1111/j.1346-8138.1986.tb02974.x

Cited by 3 publications

(3 citation statements)

References 18 publications

(20 reference statements)

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“…The BL sheath of the process would be left without cellular components and thus appear to be a partially multiplied BL. Together with the concentric BL lamination related to the regeneration process (18), this study explains previous reports that multilamination of the BL is a feature of the venous segment of dermal blood vessels (4,16,17). The word "multilamination" of the BL should be divided into two types: partial and concentric around the vascular circumference.…”

Section: Discussionsupporting

confidence: 78%

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Fine Structural Deformation of the Dermal Capillary Following Immersion Fixation Procedure

Imayama

Urabe

1986

The Journal of Dermatology

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The possibility of fine structural deformation related to skin biopsy and the subsequent immersion fixation procedure were investigated, because little attention has yet been focused on artifacts of the dermal microvasculature. Contraction of the material following biopsy removal was marked in skin regions with thin epidermis and resulted in capillary collapse. As the collapse of the vessels increased, lining cells became thicker and more rugged, endothelial fenestrations disappeared, and 10 nm filaments aggregated. Simultaneously, perivascular connective tissue material was separated from the dermal element in which the vessels were embedded and appeared as a homogenous areola around the endothelial tube. Basal lamina appeared folded and partially multilaminated around the vascular circumference, particularly in the venous segment of the microvasculature; these are considered to be the definite characteristics of dermal capillaries. In contrast to the skin regions with thin epidermis, the vessels in “well developed” dermal papillae did not collapse and bore close similarities to the perfused ones. The present study indicates that most of the so‐called characteristics of dermal capillaries in biopsy skin is attributable to artifacts following the removal of the skin before fixation.

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Section: Discussionsupporting

confidence: 78%

“…The word "multilamination" of the BL should be divided into two types: partial and concentric around the vascular circumference. Experimental formation of concentric layering of the BL will be documented in another paper (18).…”

Section: Discussionmentioning

confidence: 99%

Fine Structural Deformation of the Dermal Capillary Following Immersion Fixation Procedure

Imayama

Urabe

1986

The Journal of Dermatology

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“…The basal lamina appears denuded but without discontinuity. Its multilamellar aspect gives evidence of successive waves of basal lamina neogenesis which might be related to the iterative endothelial regeneration [28,55]. Endothelial cells are known to be responsible for fibronectin and basement membrane component synthesis [25].…”

Section: Discussionmentioning

confidence: 99%

Fibrosing vasculitis in Wegener's granulomatosis: ultrastructural and immunohistochemical analysis of the vascular lesions

Gindre¹,

Peyrol²,

Raccurt

et al. 1995

Vichows Archiv A Pathol Anat

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This study of two cases of pulmonary Wegener's granulomatosis (WG) focuses on the ultrastructural aspects of the vascular wall injury and on the immunohistochemical characterization of the perivascular connective matrix. The iterative waves of endothelial cell necrosis and regeneration are demonstrated by the multilamellar appearance of the basal lamina. Neutrophils infiltrate the vessel wall and myofibroblasts are recruited to injured vessels. The perivascular connective matrix associates basement-membrane like and fibrillar material with fibrin deposits. The initiation of the fibrosing process was assessed by the visualization of matrix molecules involved in targeting (p-fibronectin), organizing (cellular fibronectin and tenascin) and stabilizing (lysyl-oxidase) the fibrogenic activity. These elementary lesions affect different levels of the vascular tree, and capillaritis is involved in the extension of the pathological process. Lysyl-oxidase labelling reveals the fibrosing front which is located on the border of dense fibrosis. The markers of fibrosing activity disappear in the areas of fibrosis following vasculitis and/or ischaemic necrosis and/or granulomatosis. Vasculitis plays a major role in both the genesis and progression of the fibrosis observed in the late stage of WG.

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Ultraviolet-B irradiation deforms the configuration of elastic fibers during the induction of actinic elastosis in rats

Imayama

Nakamura

Takeuchi

et al. 1994

Journal of Dermatological Science

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Basal Lamina of the Dermal Capillary: Concentric Multilamination Following Regeneration Processes

Cited by 3 publications

References 18 publications

Fine Structural Deformation of the Dermal Capillary Following Immersion Fixation Procedure

Fine Structural Deformation of the Dermal Capillary Following Immersion Fixation Procedure

Fibrosing vasculitis in Wegener's granulomatosis: ultrastructural and immunohistochemical analysis of the vascular lesions

Ultraviolet-B irradiation deforms the configuration of elastic fibers during the induction of actinic elastosis in rats

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