Basal Insulin Requirement Is ∼30% of the Total Daily Insulin Dose in Type 1 Diabetic Patients Who Use the Insulin Pump

Abstract

OBJECTIVETo investigate the basal insulin requirement in total daily insulin dose in Japanese type 1 diabetic patients who use the insulin pump.RESEARCH DESIGN AND METHODSThe basal insulin requirement in 35 type 1 diabetic patients without detectable C-peptide using the insulin pump (Paradigm 712) was investigated during 2–3 weeks of hospitalization. The patients were served diabetic diets of 25–30 kcal/kg ideal body weight. Each meal omission was done to confirm stable blood glucose levels within 30 mg/dL variance until the next meal. Target blood glucose level was set at 100 mg/dL before each meal and 150 mg/dL at 2 h after each meal.RESULTSTotal daily insulin dose was 31.6 ± 8.5 units, and total basal insulin requirement was 8.7 ± 2.9 units, which was 27.7 ± 6.9% of the total daily dose.CONCLUSIONSBasal insulin requirement is ∼30% of the total daily dose in Japanese type 1 diabetic patients who use the insulin pump.

Basal Insulin Requirements after Progesterone Treatment in a Type 1 Diabetic Pregnant Woman

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Excess weight gain during insulin pump therapy is associated with higher basal insulin doses

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Assessment of factors determining an HbA1c concentration ≤7.5% in patients with type 1 diabetes

“…Previous studies have concluded that the %TBD should be approximately 50% in a population; however, other studies have indicated 30% as the optimal value . Therefore, in the present study we evaluated this discrepancy and found that 30% was the optimal value for %TBD ( R = 0.73, P < 0.01) in our study population.…”

“…Several studies have demonstrated that TDD (U/kg) can be roughly estimated as 50% of body weight . Although it is vital to determine the total basal insulin dose (TBD) as a percentage of TDD (%TBD), the actual value of %TBD for optimal glycemic control is still under debate …”