Basal ganglia structures differentially contribute to verbal fluency: Evidence from Human Immunodeficiency Virus (HIV)-infected adults

Thames, April D.; Foley, Jessica; Wright, Matthew; Panos, Stella E.; Ettenhofer, Mark L.; Ramezani, Amir; Streiff, Vanessa; El‐Saden, Suzie; Goodwin, Scott C.; Bookheimer, Susan Y.; Hinkin, Charles H.

doi:10.1016/j.neuropsychologia.2011.12.010

Cited by 37 publications

(32 citation statements)

References 45 publications

(51 reference statements)

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“…searching within a given field like house pets, and then switching to a new field like aquatic animals (Troyer et al, 1998), a deficit at this level induced by lesions to the basal ganglia could also account for our VLSM results (e.g. Troyer et al, 2004;Abutalebi et al 2009;Thames et al, 2012).…”

Section: Discussionmentioning

confidence: 66%

“…In the ganglia-thalamo-cortical loops, the DLPFC is connected to the dorsolateral caudate nucleus and the internal globus pallidus. Fluency impairments following basal ganglia disruption have notably been demonstrated in clinical studies on HIV (Thames et al, 2012), as well as in Huntington and Parkinson patients (Lawrence et al, 1998;Benke et al, 2003), and might follow from a disruption of the maintenance, monitoring and selection of goalrelevant representations by prefrontal cortices (Wagner et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

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Partly segregated cortico-subcortical pathways support phonologic and semantic verbal fluency: A lesion study

et al. 2016

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Abstract-Verbal fluency refers to the ability to generate as many words as possible in a limited time interval, without repetition and according to either a phonologic (each word begins with a given letter) or a semantic rule (each word belongs to a given semantic category). While current literature suggests the involvement of left fronto-temporal structures in fluency tasks, whether the same or distinct brain areas are necessary for each type of fluency remains unclear. We tested the hypothesis for an involvement of partly segregated cortico-subcortical structures between phonologic and semantic fluency by examining with a voxel-based lesion symptom mapping approach the effects of brain lesions on fluency scores corrected for age and education level in a group of 191 unselected braindamaged patients with a first left or right hemispheric lesion. There was a positive correlation between the scores to the two types of fluency, suggesting that common mechanisms underlie the word generation independent of the production rule. The lesion-symptom mapping revealed that lesions to left basal ganglia impaired both types of fluency and that left superior temporal, supramarginal and rolandic operculum lesions selectively impaired phonologic fluency and left middle temporal lesions impaired semantic fluency. Our results corroborate current neurocognitive models of word retrieval and production, and refine the role of cortical-subcortical interaction in lexical search by highlighting the common executive role of basal ganglia in both types of verbal fluency and the preferential involvement of the ventral and dorsal language pathway in semantic and phonologic fluency, respectively. Ó

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Partly segregated cortico-subcortical pathways support phonologic and semantic verbal fluency: A lesion study

et al. 2016

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“…28 In a study of HIV dementia, significant correlation was found between caudate volumes and phonemic word generation, whereas performance on phonemic switching predicted putamen volume. 29 In ALS, impaired verbal fluency is regarded as one of the earliest and most prevalent of neuropsychological deficits. 30 While the size of our study group is underpowered to make meaningful comparative neuropsychological Vertex-wise thalamic differences between C9orf72-positive and -negative patients with ALS (p < 0.05, corrected)…”

Section: Resultsmentioning

confidence: 99%

Basal ganglia involvement in amyotrophic lateral sclerosis

et al. 2013

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ALS is associated with widespread basal ganglia involvement. Caudate nucleus, hippocampus, and nucleus accumbens atrophy are key features of ALS. Dysfunction of frontostriatal networks is likely to contribute to the unique neuropsychological profile of ALS, dominated by executive dysfunction, apathy, and deficits in social cognition. Our quantitative imaging findings are consistent with postmortem studies and indicate that subcortical gray matter structures should be included in future biomarker studies of ALS.

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“…With regard to neural networks, phonemic fluency is neuroanatomically associated with the left inferior frontal gyrus (IFG), whereas semantic/category fluency has been linked to the superior temporal gyrus (Prince, Tsukiura, & Cabeza, 2007; Sherman & Massman, 1999). The basal ganglia (BG), preferentially targeted by HIV infection, have also been implicated in verbal fluency tasks, with reduced caudate volume significantly predicting lower phonemic fluency performance in an HIV+ sample (Thames et al, 2012). fMRI studies of HIV− samples have reported BG involvement (Fu, Morgan, Suckling, Williams, Andrew, Vythelingum, & McGuire, 2002; Wagner, Sebastian, Lieb, Tüscher, Tadić, 2014) when individuals perform executive-mediated language tasks (e.g., word generation), suggesting that the BG play a key role in lexical retrieval outside of HIV infection.…”

Section: Introductionmentioning

confidence: 99%

Increased subcortical neural activity among HIV+ individuals during a lexical retrieval task

Thames

Sayegh

Terashima

et al. 2016

Neurobiology of Disease

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Background Deficits in lexical retrieval, present in approximately 40% of HIV+ patients, are thought to reflect disruptions to frontal-striatal functions and may worsen with immunosuppression. Coupling frontal-striatal tasks such as lexical retrieval with functional neuroimaging may help delineate the pathophysiologic mechanisms underlying HIV-associated neurological dysfunction. Objective We examined whether HIV infection confers brain functional changes during lexical access and retrieval. It was expected that HIV+ individuals would demonstrate greater brain activity in frontal-subcortical regions despite only minimal differences between groups on neuropsychological testing. Within the HIV+ sample, we examined associations between indices of immunosuppression (recent and nadir CD4+ count) and task-related signal change in frontostriatal structures. Method 16 HIV+ participants and 12 HIV− controls underwent fMRI while engaged in phonemic/letter and semantic fluency tasks. Participants also completed standardized measures of verbal fluency. Results HIV status groups performed similarly on phonemic and semantic fluency tasks prior to being scanned. fMRI results demonstrated activation differences during the phonemic fluency task as a function of HIV status, with HIV+ individuals demonstrating significantly greater activation in BG structures than HIV− individuals. There were no significant differences in frontal brain activation between HIV status groups during the phonemic fluency task, nor were there significant brain activation differences during the semantic fluency task. Within the HIV+ group, current CD4+ count, though not nadir, was positively correlated with increased activity in the inferior frontal gyrus and basal ganglia. Conclusion During phonemic fluency performance, HIV+ patients recruit subcortical structures to a greater degree than HIV− controls despite similar task performances suggesting that fMRI may be sensitive to neurocompromise before overt cognitive declines can be detected. Among HIV+ individuals, reduced activity in the frontal-subcortical structures was associated with lower CD4+ count.

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Basal ganglia structures differentially contribute to verbal fluency: Evidence from Human Immunodeficiency Virus (HIV)-infected adults

Cited by 37 publications

References 45 publications

Partly segregated cortico-subcortical pathways support phonologic and semantic verbal fluency: A lesion study

Partly segregated cortico-subcortical pathways support phonologic and semantic verbal fluency: A lesion study

Basal ganglia involvement in amyotrophic lateral sclerosis

Increased subcortical neural activity among HIV+ individuals during a lexical retrieval task

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