Basal ganglia mechanisms underlying precision grip force control

Prodoehl, Janey; Corcos, Daniel M.; Vaillancourt, David E.

doi:10.1016/j.neubiorev.2009.03.004

Cited by 95 publications

(90 citation statements)

References 108 publications

(121 reference statements)

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“…Moreover, a correlation between BG activity and the velocity or amplitude of the movement was shown in normal subjects using PET (Thobois et al, 2007;Turner et al, 2003) or fMR imaging (Grafton and Tunik, 2011). Prodoehl et al (2009) proposed that dorsal BG (including the internal pallidum) also regulate the parametrization of grip force, whereas changes in fMRI BOLD signal in the ventral BG scale with the prediction of force amplitude (Vaillancourt et al, 2004(Vaillancourt et al, , 2007. Based on these observations it has been suggested that basal ganglia output regulates (among other behavioral and sensory dimensions) movement gain (Turner and Desmurget, 2010).…”

Section: Discussionmentioning

confidence: 99%

Scaling of Movement Is Related to Pallidal γ Oscillations in Patients with Dystonia

Brücke¹,

Huebl²,

Schönecker³

et al. 2012

J. Neurosci.

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Neuronal synchronization in the gamma (␥) band is considered important for information processing through functional integration of neuronal assemblies across different brain areas. Movement-related ␥ synchronization occurs in the human basal ganglia where it is centered at ϳ70 Hz and more pronounced contralateral to the moved hand. However, its functional significance in motor performance is not yet well understood. Here, we assessed whether event-related ␥ synchronization (ERS) recorded from the globus pallidus internus in patients undergoing deep brain stimulation for medically intractable primary focal and segmental dystonia might code specific motor parameters. Pallidal local field potentials were recorded in 22 patients during performance of a choice-reaction-time task. Movement amplitude of the forearm pronation-supination movements was parametrically modulated with an angular degree of 30°, 60°, and 90°. Only patients with limbs not affected by dystonia were tested. A broad contralateral ␥ band (35-105 Hz) ERS occurred at movement onset with a maximum reached at peak velocity of the movement. The pallidal oscillatory ␥ activity correlated with movement parameters: the larger and faster the movement, the stronger was the synchronization in the ␥ band. In contrast, the event-related decrease in beta band activity was similar for all movements. Gamma band activity did not change with movement direction and did not occur during passive movements. The stepwise increase of ␥ activity with movement size and velocity suggests a role of neuronal synchronization in this frequency range in basal ganglia control of the scaling of ongoing movements.

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Section: Discussionmentioning

confidence: 99%

Scaling of Movement Is Related to Pallidal γ Oscillations in Patients with Dystonia

Brücke¹,

Huebl²,

Schönecker³

et al. 2012

J. Neurosci.

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“…The basal ganglia have long been associated with the scaling of effort or force. Imaging studies in healthy humans have suggested that basal ganglia nuclei, in particular the internal portion of the globus pallidus and the subthalamic nucleus (STN), are involved in encoding gripping force amplitude and rate (Spraker et al, 2007;Prodoehl et al, 2009). Neuronal recordings in monkeys have also suggested that the basal ganglia play an important role in the control of the scaling of motor responses measured in terms of their amplitude or velocity (DeLong et al, 1984;Turner and Anderson, 1997).…”

Section: Introductionmentioning

confidence: 99%

Subthalamic Nucleus Local Field Potential Activity Helps Encode Motor Effort Rather Than Force in Parkinsonism

et al. 2015

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Local field potential (LFP) recordings from patients with deep brain stimulation electrodes in the basal ganglia have suggested that frequency-specific activities correlate with force or effort, but previous studies have not been able to disambiguate the two. Here, we dissociated effort from actual force generated by contrasting the force generation of different fingers while recording LFP activity from the subthalamic nucleus (STN) in patients with Parkinson's disease who had undergone functional surgery. Patients were studied while on their normal dopaminergic medication. We investigated the relationship between frequency-specific oscillatory activity in the STN and voluntary flexion of either the index or little finger at different effort levels. At each tested effort level (10%, 25%, and 40% of the maximal voluntary contraction force of each individual finger), the index finger generated larger force than the little finger. Movementrelated suppression of beta-band power in the STN LFP was significantly modulated by effort, but not by which finger was used, suggesting that the beta suppression in the STN LFP during sustained contraction serves as a proxy for effort. The absolute force scaled with beta power suppression, but with the scaling determined by the maximal voluntary contraction force of the motor effector. Our results argue against the hypothesis that the basal ganglia are directly involved in the parameterization of force during movement and support a role of the STN in the control of motor effort to be attributed to a response.

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“…The basal ganglia are involved in the control of precision grip force, and both are disturbed in HD patients (Prodoehl et al 2009). We found a significant improved performance on the grid force of R6/2 treated with AdB which could be explained by a recovery of striatal functioning compared with AdZ control mice.…”

Section: Discussionmentioning

confidence: 99%

Adenoviral Astrocyte-Specific Expression of BDNF in the Striata of Mice Transgenic for Huntington’s Disease Delays the Onset of the Motor Phenotype

et al. 2011

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Huntington's disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. The most characteristic structural feature of this disease is neurodegeneration accompanied by gliosis in the striatum. BDNF has been proposed to protect striatal neurons from degeneration, because it is an important survival factor for these neurons from development to adulthood. Considering the extensive gliosis and the survival effects of BDNF, we constructed an adenovirus to express a BDNF cDNA in astrocyte cells using a promoter of the glial fibrillary acidic protein gene. Cells stably transfected in vitro with a BDNF cDNA driven by this promoter expressed BDNF and responded to external stimuli increasing BDNF production. When the vector was applied into the striata of mice transgenic for HD, long-term expression of the transgene was observed, associated with a delay of onset of the motor phenotype of the R6/2 HD transgenic mice. The present data indicate that the striatal expression of BDNF is a potential adjuvant for the treatment of HD.

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Basal ganglia mechanisms underlying precision grip force control

Cited by 95 publications

References 108 publications

Scaling of Movement Is Related to Pallidal γ Oscillations in Patients with Dystonia

Scaling of Movement Is Related to Pallidal γ Oscillations in Patients with Dystonia

Subthalamic Nucleus Local Field Potential Activity Helps Encode Motor Effort Rather Than Force in Parkinsonism

Adenoviral Astrocyte-Specific Expression of BDNF in the Striata of Mice Transgenic for Huntington’s Disease Delays the Onset of the Motor Phenotype

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