Basal ganglia lesions in children and adults

Bekiesińska‐Figatowska, Monika; Mierzewska, Hanna; Jurkiewicz, Elżbieta

doi:10.1016/j.ejrad.2012.12.006

Cited by 85 publications

(61 citation statements)

References 27 publications

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“…Recently, they have been also found in patients with nonsyndromic bilateral striatal necrosis (BSN) [6,7] that is a frequent but nonspecific MRI feature observed in patients with an extrapyramidal syndrome, some of which had DSH [1]. Bilateral striatal necrosis was the most frequently reported in individuals with mitochondrial pathology presenting Leigh syndrome (LS) and MTATP6 mutation [3], thiamine metabolism dysfunction syndrome related to SLC25A19 pathogenic variants [11], and glutaric aciduria I with GCDH variants [4], but rarely in Wilson's and Huntington diseases and other of inherited etiology as well as of certain acquired causes [1]. The prognosis for BSN is variable, with patients completely recovered and others developing severe dystonia or a more akinetic-rigid phenotype [7].…”

Section: Introductionmentioning

confidence: 99%

Bilateral striatal necrosis caused by ADAR mutations in two siblings with dystonia and freckles-like skin changes that should be differentiated from Leigh syndrome

Piekutowska‐Abramczuk¹,

Mierzewska²,

Bekiesińska‐Figatowska³

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Bilateral striatal necrosis caused by ADAR mutations in two siblings with dystonia and freckles-like skin changes that should be differentiated from Leigh syndrome

Piekutowska‐Abramczuk¹,

Mierzewska²,

Bekiesińska‐Figatowska³

et al. 2016

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“…Fahr's disease, also known as idiopathic basal ganglia calcification, is characterized by accumulation of calcium deposits in the regions of the basal ganglia, which may also affect regions of the caudate nucleus, the putamen, thalamus, the white matter, and the cerebellum (1,2) . The appearance of calcium deposits, usually bilateral and benign, is associated with genetic, metabolic, or infectious changes.…”

Section: Introductionmentioning

confidence: 99%

“…Among the pathologies that can also cause calcium accumulation, one can highlight hypothyroidism, pseudo-hypothyroidism, mitochondrial myopathy, Wilson's disease, lupus erythematosus, Down syndrome, and neurobrucellosis. Despite this, some individuals develop these calcium deposits and have no well-defined etiology, cases in which the cerebral calcification is characterized as Fahr's disease (1)(2)(3) . The diagnosis of Fahr's disease is considered when there is exclusion of other conditions that may also cause bilateral calcification of the basal ganglia and other brain regions.…”

Section: Introductionmentioning

confidence: 99%

Dysfunctions of the stomatognathic system and vocal aspects in Fahr disease: case report

Santos

Fraga

Cardoso

2014

CoDAS

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The aim of this study is to report the case of a patient with Fahr's Disease in order to describe the main stomatognathic and vocal changes that can be found in individuals with this disease. In order to establish the diagnosis, an assessment of the conditions of orofacial motor system and speech production, as well the efficiency of swallowing, was realized. Based on these assessments, there were difficulties in coordinating and sustaining muscle during speech and presence of oropharyngeal dysphagia. Speech disorders found in Fahr's disease manifest themselves in complex and cover various aspects of phonological knowledge and the diseases that affect the basal ganglia have similar frames of speech-language disorders of the stomatognathic system, being able to present a picture of dysarthria.

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“…Bekiesinska et al made a summary of unilateral basal ganglia lesions in children and adults. 33 A scholar showed that there was abnormality in unilateral brain regions of asymptomatic HIV-infected subjects. Bladowska found that the relative blood volume values of HIV-infected persons were significantly lower than those of healthy controls in the right side of the temporal-parietal cortex and the left side of prefrontal cortex.…”

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confidence: 99%

Application of brain multi-b-value diffusion-weighted imaging (DWI) in adolescent orphans from AIDS families

Jiang

Zhong

Zhou

et al. 2016

BJR

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Objective: To evaluate the application value of multib-value diffusion-weighted imaging (DWI) with monoexponential model and stretched-exponential model in the diagnosis of HIV-positive patients. Methods: 50, 150, 200, 400, 600, 800 s mm 22) DWI was performed in 23 adolescent orphans from AIDS families, including 15 HIV-positive subjects and 8 HIV-negative healthy subjects. Apparent diffusion coefficient (ADC) values were fitted by monoexponential model; distribution diffusion coefficient (DDC) values and heterogeneity index (a) values were fitted by stretched-exponential model in bilateral basal ganglia, then non-parametric tests were performed. Results: The signal intensity attenuation in multi-b-value DWI could be well described by both mono-exponential model and stretched-exponential model. In the left basal ganglia, mean a-values in HIV-positive subjects (a 5 0.848 6 0.068) were significantly lower than that in healthy subjects (a 5 0.923 6 0.050, p 5 0.013). There was no statistical difference of a-values between HIV-positive subjects and healthy control subjects in the right basal ganglia. Apart from these, there were also no statistical differences of DDC values or ADC values between two groups in bilateral basal ganglia (all p . , we can see stretched-exponential model DWI can provide more information than mono-exponential model DWI. Advances in knowledge: Multi-b-value DWI was performed in subjects with HIV. DWI measurements could be neuroimaging biomarkers of cerebral injury in the course of HIV infection.

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Basal ganglia lesions in children and adults

Cited by 85 publications

References 27 publications

Bilateral striatal necrosis caused by ADAR mutations in two siblings with dystonia and freckles-like skin changes that should be differentiated from Leigh syndrome

Bilateral striatal necrosis caused by ADAR mutations in two siblings with dystonia and freckles-like skin changes that should be differentiated from Leigh syndrome

Dysfunctions of the stomatognathic system and vocal aspects in Fahr disease: case report

Application of brain multi-b-value diffusion-weighted imaging (DWI) in adolescent orphans from AIDS families

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