Basal ganglia-diencephalon synaptic relations in the cat. II. Intracellular recordings from dorsal thalamic neurons during low frequency stimulation of the caudatothalamic projection systems and the nigrothalamic pathway

Frigyesi, Tamas L.; Machek, J.

doi:10.1016/0006-8993(71)90372-6

Cited by 40 publications

(4 citation statements)

References 68 publications

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“…With respect to their electrographic and temporal properties, these orthodromically evoked negative waves were indistinguishable from the classical recruiting responses elicited only by direct stimulation of medial thalamic nuclei [7]. However, the underlying events in the electrothalamogram differed from those reported from VL during 8--10 Hz stimulation of MT [13,14,24]: the alternating short-duration (10--20 msec) negative waves and longduration (up to 100 msec) positive waves (extracellular reflections of EPSP-IPSP sequences simultaneously generated in large populations of VL neurons) [14] were not demonstrable under these conditions. Further, all CR evoked VL potentials, except the antidromic spikes, were attenuated or abolished (Fig.…”

Section: F Effects Of L-dopa On Corona Radiata Evoked Telen-and Dienmentioning

confidence: 53%

“…Rhythmic activities in VL, developing in close time relations with neocortical low-frequency, high-amplitude negative waves, however, were demonstrable after a belated, second injection of L-Dopa (Fig. 5, at 14 hours); under these conditions, VL-motor cortex functional relationships were similar to those demonstrable in enc@hal8 isol~ cats [13,24]. Figure 6 illustrates the typical observation on medial thalamusmotor cortex functional relationships following administration of a single dose of 200 mg/kg L-Dopa to the comatose squirrel monkey.…”

Section: Effects Of Medial Thalamic Stimulation In the Comatose Sqmentioning

confidence: 57%

“…5). In previous studies, "spontaneous" or evoked bursts of slow-waves, and full-blown and abortive spindle bursts [15,23] in the MC were commonly associated with rhythmically recurring diphasic (negative-positive) waves in the extracellular [15], and EPSP-IPSP sequences in the intracellular [13,24] recordings. This high correlation between MC and VL activities was negligibly affected by placement of electrodes (sampling) at either recording site.…”

Section: Discussionmentioning

confidence: 99%

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Electrophysiological analysis of the effects of L-Dopa on the reciprocal corticothalamic projections in the squirrel monkey

Frigyesi

Yahr

Schwartz

1974

J. Neural Transmission

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SummaryEffects of i.p. administered L-Dopa was studied on the reciprocal corticothalamic projections in the squirrel monkey.1. Pendular rotation of the mediastinum produced electrocardiographic abnormalities and electrocorticograms which failed to show detectable spontaneous and evoked activities. Following administration of L-Dopa, persistent, high-amplitude, slow-wave bursts developed in the motor cortex. Increased unitary activity of medial thalamic neurons preceeded the development of neocortical spindle bursts. Diphasic (negative-positive) waves in medial thalamic nuclei were temporally linked to the neocortical slow-waves; such rhythmic activities in VL were not observed during motor cortical spindle bursts, 2. Low-frequency (8--10Hz) stimulation of the medial thalamus, which failed to elicit recruiting responses, triggered spindle bursts in the motor cortex in the untreated, comatose squirrel monkey. The electrographic properties of medial thalamus triggered bursts were essentially similar to those induced later by L-Dopa in the same comatose animals. 3. In the non-comatose animals, L-Dopa attenuated all short-latency components of corona radiata evoked potentials in the motor cortex, medial and ventrolateral thalamus. Concomitantly, orthodromically evoked longlatency recruiting responses were demonstrable in the motor cortex. The data indicate that one of the major effects of L-Dopa in the diencephalon is the disfacilitation of VL neurons which, in turn, disinhibit neurons in the medial thalamic nuclei.

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Section: F Effects Of L-dopa On Corona Radiata Evoked Telen-and Dienmentioning

confidence: 53%

Section: Effects Of Medial Thalamic Stimulation In the Comatose Sqmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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Electrophysiological analysis of the effects of L-Dopa on the reciprocal corticothalamic projections in the squirrel monkey

Frigyesi

Yahr

Schwartz

1974

J. Neural Transmission

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“…There are many studies report ing the effect of nigral stimulation on thalamic neurons [26,29], but all have been done in the cat in acute experiments. In such conditions, it is impossible to stimulate only nigral cells for two reasons.…”

Section: Nigrolhalamic Projectionmentioning

confidence: 99%

Connections from the Basal Ganglia to the Thalamus

Deniau¹,

Guyader²,

Ohye³

1976

Stereotact Funct Neurosurg

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Many data suggest that the basal ganglia exerts an indirect influence onto the motor cortex through the thalamus which receives pallidal and nigral efferences. According to the anatomical data, the internal segment of globus pallidus projects to the VL-VA and CM of thalamus and the substantia nigra sends axons ending in the VL and VA with an intranuclear organization which did not overlap the pallidal terminations. The electrophysiological records in the VL-VA nucleus demonstrate that pallidal stimulation induces an inhibitory response, mainly on thalamic neurons, which does not receive cerebellar input. If spreading of excitation is avoided, nigral stimulation also induces an inhibition at the thalamic level. This inhibitory effect can be recorded on relay cells with cerebellar input and cortical output as well as on nonrelay cells. The electrophysiological results in the case of the striatopallidal and striatonigral projections are also briefly reported.

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Projections from the substantia nigra pars reticulata to the motor thalamus of the rat: Single axon reconstructions and immunohistochemical study

Kha

Finkelstein

Tomas

et al. 2001

J of Comparative Neurology

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This is a study in the rat of the distribution of specific neurotransmitters in neurones projecting from the substantia nigra reticulata (SNR) to the ventrolateral (VL) and ventromedial (VM) thalamic nuclei. Individual axons projecting from the SNR to these thalamic nuclei have also been reconstructed following small injection of the anterograde tracer dextran biotin into the the SNR. Analysis of reconstructions revealed two populations of SNR neurones projecting onto the VL and VM thalamic nuclei. One group projects directly onto the VM and VL, and the other projects to the VM/VL and to the parafascicular nucleus. In another set of experiments Fluoro-Gold was injected into the VL/VM to label SNR projection neurones retrogradely, and immunohistochemistry was performed to determine the distribution of choline acetyltransferase (ChAT), vesicular acetylcholine transporter (VAChT), gamma-aminobutyric acid (GABA), and glutamate in Fluoro-Gold-labelled SNR projection neurones. Most SNR-VL/VM thalamic projection neurones were immunoreactive to acetylcholine or glutamate, whereas only 25% of the projection neurones were found to be immunoreactive to GABA.

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Basal ganglia-diencephalon synaptic relations in the cat. II. Intracellular recordings from dorsal thalamic neurons during low frequency stimulation of the caudatothalamic projection systems and the nigrothalamic pathway

Cited by 40 publications

References 68 publications

Electrophysiological analysis of the effects of L-Dopa on the reciprocal corticothalamic projections in the squirrel monkey

Electrophysiological analysis of the effects of L-Dopa on the reciprocal corticothalamic projections in the squirrel monkey

Connections from the Basal Ganglia to the Thalamus

Projections from the substantia nigra pars reticulata to the motor thalamus of the rat: Single axon reconstructions and immunohistochemical study

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