Basal ganglia calcification and psychotic symptoms in the very old

Abstract

BGC is strongly associated with psychotic symptoms in very old age, possibly due to a disturbance in the basal ganglia dopaminergic system.

Computerized tomography findings in Fahr's syndrome

“…Usually, the dystrophic form is silent or occur with extrapyramidal symptoms 18 . Since no associated disease was identified as responsible by these clinical features, in agreement with previous studies 7 we suppose that dystrophic calcifications in other places than globus pallidus (for example, dentate nucleus and semioval center as occurs in this patient), are related to other symptoms in adults (particularly to psychiatric disorders) [19][20][21] .…”

Catatonia and psychosis in a case suggesting Fahr's disease

“…Evidence supports that alterations in the basal ganglia and their corresponding projections to nonmotor areas of cerebral cortex are present in psychotic disorders [9][10][11]. Patients with Fahr's disease have been shown to have a higher risk of developing psychotic symptoms than control subjects [12].…”

Fahr's disease with Epilepsy: A Case Report

“…Although calcification can involve other structures, globus pallidus is by far the most common site, with lateral pallidus been more affected than the medial. 9 The exact pathological process initiating the calcifying changes is not known, it may reflect slowly progressive metabolic or inflammatory processes in the brain, which subsequently calcifies and is probably responsible for the neurologic deficit observed. Several approaches based on diverse biological theories and small scale clinical experiences have been proposed for management of FD.…”