Basal ganglia and cerebellar circuits have distinct roles in blepharospasm

Glickman, Amanda; Nguyen, Phuong; Shelton, Erika; Peterson, David A.; Berman, Brian D.

doi:10.1016/j.parkreldis.2020.06.034

Cited by 13 publications

(15 citation statements)

References 30 publications

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“…Unfortunately, we did not observe any correlations between dALFF variability in the right PMC, dFC strength of the right PMC with ipsilateral cerebellum (lobule VIII), and symptom severity in patients with BSP, which contradicts the current view that the corticoponto-cerebello-thalamo-cortical circuit is involved in symptom severity across different forms of focal dystonia [47,48]. However, such a view is based on the shared findings that functional activity in the sensorimotor cortex and cerebellar lobule VI is related to the severity of dystonic symptoms in both BSP and cervical dystonia populations [47,48]. These researchers believe that basal ganglia circuits in BSP are associated with the triggering of spasms, whereas cerebello-cortical circuits involving cerebellar lobule VI have a key role in symptom severity.…”

Section: Discussioncontrasting

confidence: 99%

“…Therefore, our findings add to the growing body of evidence supporting the notion that dystonia is a large-scale dysfunction, involving not only the cortico-basal ganglia-thalamo-cortical loop, but also the cortico-ponto-cerebello-thalamo-cortical circuit as well [46]. Unfortunately, we did not observe any correlations between dALFF variability in the right PMC, dFC strength of the right PMC with ipsilateral cerebellum (lobule VIII), and symptom severity in patients with BSP, which contradicts the current view that the corticoponto-cerebello-thalamo-cortical circuit is involved in symptom severity across different forms of focal dystonia [47,48]. However, such a view is based on the shared findings that functional activity in the sensorimotor cortex and cerebellar lobule VI is related to the severity of dystonic symptoms in both BSP and cervical dystonia populations [47,48].…”

Section: Discussioncontrasting

confidence: 94%

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Abnormal dynamic brain activity and functional connectivity of primary motor cortex in blepharospasm

Luo

Guo

Zhong

et al. 2022

Euro J of Neurology

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Background and purpose: Accumulating evidence indicates that dynamic amplitude of low-frequency fluctuations (dALFF) or dynamic functional connectivity (dFC) can provide complementary information, distinct from static amplitude of low-frequency fluctuations (sALFF) or static functional connectivity (sFC), in detecting brain functional abnormalities in brain diseases. We aimed to examine whether dALFF and dFC can offer valuable information for the detection of functional brain abnormalities in patients with blepharospasm. Methods:We collected resting-state functional magnetic resonance imaging data from 46 patients each of blepharospasm, hemifacial spasm (HFS), and healthy controls (HCs).We examined intergroup differences in sALFF and dALFF to investigate abnormal regional brain activity in patients with blepharospasm. Based on the dALFF results, we conducted seed-based sFC and dFC analyses to identify static and dynamic connectivity changes in brain networks centered on areas showing abnormal temporal variability of local brain activity in patients with blepharospasm.Results: Compared with HCs, patients with blepharospasm displayed different brain functional change patterns characterized by increased sALFF in the left primary motor cortex (PMC) but increased dALFF variance in the right PMC. However, differences were not found between patients with HFS and HCs. Additionally, patients with blepharospasm exhibited decreased dFC strength, but no change in sFC, between right PMC and ipsilateral cerebellum compared with HCs; these findings were replicated when patients with blepharospasm were compared to those with HFS. Conclusions:Our findings highlight that dALFF and dFC are complementary to sALFF and sFC and can provide valuable information for detecting brain functional abnormalities in blepharospasm. Blepharospasm may be a network disorder involving the cortico-pontocerebello-thalamo-cortical circuit.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 94%

Abnormal dynamic brain activity and functional connectivity of primary motor cortex in blepharospasm

Luo

Guo

Zhong

et al. 2022

Euro J of Neurology

View full text Add to dashboard Cite

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“…Multiple regions including the thalamus, lower brainstem, basal ganglia, cerebellum, midbrain, and cortex may participate in its pathophysiology (19). A functional magnetic resonance imaging-based study showed that basal ganglia circuits and cerebello-cortical circuits are involved in the triggering and development of blepharospasm (20). Interestingly, the two circuits also play an important role in PD (21).…”

Section: Discussionmentioning

confidence: 99%

Case report: Blepharospasm in peak-dose dyskinesia may benefit from amantadine in Parkinson's disease

Fan

Zhang²,

Hu³

et al. 2022

Front. Neurol.

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IntroductionBlepharospasm is uncommon in Parkinson's disease, especially in the peak-dose dyskinesia period.Case presentationWe herein present the case of a patient with PD who developed blepharospasm in the peak-dose dyskinesia period. The symptom was improved by taking amantadine.ConclusionThe current report expands the phenomenology of peak-dose dykinesia in PD to include dystonic blepharospasm. This complication of levodopa therapy may respond to amantadine despite the dystonic appearance of movements.

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“…Functional connectivity analyses have further demonstrated reductions in connectivity between the basal ganglia and primary/secondary sensorimotor areas, the cingulate cortex, and the parietal associate cortex in BSP patients as well as decreased connectivity between cerebellum and somatosensory cortex ( 9 ). Besides, the intensity of eyelid muscle spasms in BSP patients was associated with increased BOLD activity in the sensorimotor cortex and cerebellum ( 10 ). Structural MRI analyses performed via a voxel-based morphometry (VBM) approach have also exhibited widespread inconsistent gray matter (GM) abnormalities in the basal ganglia and cortical areas of patients with CCD ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Altered Structural Brain Network Topology in Patients With Primary Craniocervical Dystonia

Wang

et al. 2022

Front. Neurol.

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PurposeRegional cortical thickness or volume analyses based upon structural MRI scans have been employed to study the pathophysiology of primary craniocervical dystonia (CCD). In the present study, brain connectivity network analyses based upon morphological distribution similarities among different brain areas were used to study the network disruption in individuals affected by CCD.MethodsThe T1 MRI scans were completed for 37 patients with CCD and 30 healthy controls, with individual brain structural networks being constructed based upon gray matter (GM) similarities in 90 regions within the brain. Area under the curve (AUC) values for each network parameter were determined, and the GRETNA program was used to conduct a graph theory-based measurement of nodal and global network properties. These properties were then compared between healthy controls and those with CCD. In addition, relationships between nodal properties and the severity of clinical dystonia were assessed through Spearman's correlation analyses.ResultsRelative to individuals in the control group, patients with CCD exhibited decreased local nodal properties in the right globus pallidus, right middle frontal gyrus, and right superior temporal pole. The degree of centrality as well as the node efficiency of the right globus pallidus were found to be significantly correlated with ocular dystonic symptom. The node efficiency of right middle frontal gyrus was significantly related to the total motor severity. No nodal properties were significantly correlated with oral dystonic motor scores. Among CCD patients, the right hemisphere exhibited more widespread decreases in connectivity associated with the motor related brain areas, associative cortex, and limbic system, particularly in the middle frontal gyrus, globus pallidus, and cingulate gyrus.ConclusionsThe assessment of morphological correlations between different areas in the brain may represent a sensitive approach for detecting alterations in brain structures and to understand the mechanistic basis for CCD at the network level. Based on the nodal properties identified in this study, the right middle frontal gyrus and globus pallidus were the most severely affected in patients with CCD. The widespread alterations in morphological connectivity, such as the cortico-cortical and cortico-subcortical networks, further support the network mechanism as a basis for CCD.

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Basal ganglia and cerebellar circuits have distinct roles in blepharospasm

Cited by 13 publications

References 30 publications

Abnormal dynamic brain activity and functional connectivity of primary motor cortex in blepharospasm

Abnormal dynamic brain activity and functional connectivity of primary motor cortex in blepharospasm

Case report: Blepharospasm in peak-dose dyskinesia may benefit from amantadine in Parkinson's disease

Altered Structural Brain Network Topology in Patients With Primary Craniocervical Dystonia

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