Basal energy expenditure and diet- induced modifications to thermogenesis in short bowel syndrome

Justino, Sandra; Dias, Maria Carolina Gonçalves; Maculevicius, J; Colugnati, Fernando Antônio Basile; Sing, Teng Chang; Halpern, Alfredo; Gama-Rodrigues, Joaquim; Waitzberg, Dan Linetzky

doi:10.1016/j.clnu.2004.06.008

Cited by 10 publications

(8 citation statements)

References 40 publications

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“…In one human study, basal EE was found to be no different in 8 SBS patients when compared with normal controls as measured by indirect calorimetry [19]. In contrast with the present study, the patients comprising that analysis were likely to be well into a plateau phase of adaptation because they were at least 2 years out from their initial SBR.…”

Section: Discussioncontrasting

confidence: 67%

Body composition and metabolic changes associated with massive intestinal resection in mice

Tantemsapya

Meinzner-Derr

Erwin

et al. 2008

Journal of Pediatric Surgery

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Section: Discussioncontrasting

confidence: 67%

Body composition and metabolic changes associated with massive intestinal resection in mice

Tantemsapya

Meinzner-Derr

Erwin

et al. 2008

Journal of Pediatric Surgery

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“…Basal energy expenditure calculated using Harris-Benedict and Schofield equations has been shown to be significantly higher than REE obtained by IC in adults with SBS. 28 In our current study, the WHO equation underestimated or overestimated the energy expenditure by a wide margin and as a result, patients were at a high risk of unintended underfeeding or overfeeding. Underfeeding in children with IF may result in growth failure.…”

Section: Discussionmentioning

confidence: 48%

Variability of Resting Energy Expenditure in Infants and Young Children With Intestinal Failure–Associated Liver Disease

Duro

Mitchell²,

Mehta³

et al. 2014

J. pediatr. gastroenterol. nutr.

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Objective To determine, in a cohort of young children with intestinal failure (IF), if estimates of basal metabolic rate (BMR) by standard equations, approximate measured REE by indirect calorimetry (IC). Methods IC was performed by dilutional canopy technique. REE measurements were compared to standard, age-based estimation equations (WHO) for BMR. Subjects were classified as hypermetabolic (REE > 110% BMR), hypometabolic (REE < 90% BMR), or normal (REE = 90–110% BMR). Results Twenty-eight IF patients (11 female, 17 male) had an underlying diagnosis of necrotizing enterocolitis (n=10) or a congenital gastrointestinal defect (n=18). Median age was 5.3 months. Median (IQR) REE was 46 (42, 58) kcal/kg/day. Median (IQR) total energy intake provided 209 (172, 257)% of REE, with parenteral nutrition providing 76% (23%) of total energy intake. REE was variable, with 39% (n=11) of measurements hypermetabolic, 39% (n=11) hypometabolic, and the remaining 21% (n=6) normal. Although REE was well correlated with estimated BMR (r = 0.82, P < 0.0001), estimated BMR was not consistently an adequate predictor of REE. BMR over- or under-estimated REE by more than 10 kcal/kg/d in 15/28 (54%) patients. REE was not significantly correlated with severity of liver disease, nutritional status, total energy intake or gestational age. Conclusions Energy expenditure is variable among children with IF and IFALD, with nearly 80% of our cohort exhibiting either hypo- or hypermetabolism. Standard estimation equations frequently do not correctly predict individual REE. Longitudinal studies of energy expenditure and body composition may be needed to guide provision of nutrition regimens.

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“…It is important to note that not all surgical manipulations of the GI tract lead to increased EE. Rats and humans with short bowel syndrome and associated malabsorption exhibit no change in TEE and REE (40,41). We have recently performed EE measurements in rats that have undergone other GIWLS procedures (sleeve gastrectomy and gastric banding) in which the only alteration is the reduction of stomach size, and we observed that these manipulations had no significant effect on EE (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Roux‐en‐Y Gastric Bypass Enhances Energy Expenditure and Extends Lifespan in Diet‐induced Obese Rats

Stylopoulos

Hoppin

Kaplan

2009

Obesity

172

155

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Gastrointestinal weight-loss surgery (GIWLS) is currently the most effective treatment for severe obesity, with Roux-en-Y gastric bypass (RYGB) among the best of the available surgical options. Despite its widespread clinical use, the mechanisms by which RYGB induces its profound weight loss remain largely unknown. This procedure effects weight loss by altering the physiology of weight regulation and eating behavior rather than by simple mechanical restriction and/or malabsorption as previously thought. To study how RYGB affects the physiology of energy balance, we developed a rat model of this procedure. In this report, we demonstrate that RYGB in diet-induced obese (DIO) rats induces a 25% weight loss, prolongs mean survival by 45%, and normalizes glucose homeostasis and lipid metabolism. RYGB induced a 19% increase in total and a 31% increase in resting energy expenditure (REE). These effects, along with a 17% decrease in food intake and a 4% decrease in nutrient absorption account for the normalization of body weight after this procedure. These effects indicate that surgery acts by altering the physiology of weight regulation and help to explain the effectiveness of RYGB in comparison to restrictive dieting and other forms of dietary and pharmacological therapies for obesity. The clinical effectiveness of RYGB and its physiological effects on body weight regulation and energy expenditure (EE) suggest that this operation provides a unique opportunity to explore the mechanisms of energy homeostasis and to identify novel therapies for obesity and related metabolic diseases.

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Basal energy expenditure and diet- induced modifications to thermogenesis in short bowel syndrome

Cited by 10 publications

References 40 publications

Body composition and metabolic changes associated with massive intestinal resection in mice

Body composition and metabolic changes associated with massive intestinal resection in mice

Variability of Resting Energy Expenditure in Infants and Young Children With Intestinal Failure–Associated Liver Disease

Roux‐en‐Y Gastric Bypass Enhances Energy Expenditure and Extends Lifespan in Diet‐induced Obese Rats

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