Basal Cell Nevus Syndrome

The Nevoid Basal Cell Carcinoma Syndrome

“…This finding is contrary to the proposal of sex linkage by Clendenning et al (1964). The birth order of individuals in sibships segregating for the syndrome showed no significant departure from randomness in the earlier study of Anderson et al (1964).…”

“…In the remaining seven propositi, the presenting complaint was referable to multiple and recurring cysts of the jaws, which first developed at an average age of 15 years. The clinical features of the components that characterize the syndrome have been adequately summarized in recent reviews and need not be repeated (Clendenning et al, 1964;Howell et al, 1964;and Gorlin et al, 1965). The microscopic features were summarized by Maddox et al (1964), Mason et al (1965), and Graham et al (1965).…”

“…The microscopic features were summarized by Maddox et al (1964), Mason et al (1965), and Graham et al (1965). The clinical, pathologic, genetic, and therapeutic aspects of the syndrome were recently summarized at a clinical conference (see Clendenning, 1966).…”

Neurologic Symptoms of Basal Cell Nevus Syndrome

“…The syndrome has been described by Binkley and Johnson (1), Howell and Caro (17) and Gorlin and Goltz (9). Additional clinical reports can be found in Gorlin et al (10,11), and Clendenning et al (6) have presented a thorough review of the literature. Previous find ings have led to the conclusion that this condi tion is inherited as an autosomal dominant trait (10,19,22).…”

Basal Cell Nevus Syndrome Associated with Malignant Melanoma of the Iris

“…Later reports [2,3] summarized further work pointing to the existence of a basal cell nevus syndrome, in which multiple basal cell carcinomas are associated with varyingly combined anomalies of the osseous, nervous, ophthalm ic and repro ductive systems, as well as soft tissues. To date, more than 100 cases of this syndrome have been described.…”