Basal cell carcinoma: new opportunities for pathogenetic therapy

Pisklakova, T. P.

doi:10.17116/klinderma201464-8

Cited by 4 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, the effectiveness of a pulsed dye laser (PDL), which has been successfully used for the selective photodestruction of vessels of increased diameter as a non-surgical method for the treatment of BCC, has been confirmed in some studies [12][13][14] . Despite the relatively low frequency of metastasis of BCC, 22 a recurrence rate after the PDL treatment ranges from 5 to 10 %, which is attributed by the authors 9 to the insufficient energy exposure provided by the PDL.…”

Section: Discussionmentioning

confidence: 85%

Treatment of Basal Cell Cancer With a Pulsed Copper Vapor Laser: A Case Series

Ponomarev

Topchiy

et al. 2019

J Lasers Med Sci

View full text Add to dashboard Cite

Introduction: Basal cell carcinoma (BCC) is the most prevalent form of non-melanoma skin cancer commonly arising in elderly patients. Currently, many laser systems are applied for the treatment of BCC. However, up to the present, there have been several reports concerning ocular side effects due to the laser procedure in the borders of the periorbital area. This determines the feasibility of testing new laser surgical modes for the management of periorbital BCC. This stuay aimed to estimate both the efficacy, the early post-radiated side effects and long-term outcomes of the CVL treatment of periorbital BCC. Patients and Methods: Two men and 6 women aged 50 to 77 years were diagnosed with periorbital BCC according to the data of both the clinical evaluation and histological examination of the tissue samples taken from the involved area. Six months after the laser treatment, the histological examination of skin samples from the borderline of the irradiated area was made again. All patients were followed for 24 months after the laser treatment of BCC. The laser treatment was administered during one session of copper vapor laser (CVL) (Yakhroma-Med model). The treatment included CVL radiation with a wavelength of 511 nm and 578 nm, in the ratio of 3:2. The power level was set up to 3 W, and the exposure time was equal from 200 to 600 ms. The pulse duration accounted for 15 ns. The diameter of the light spot on the skin surface amounted to 1 mm. Results: Dual-wavelengths CVL treatment of periorbital BCC provided a complete elimination of malignant cells and dysplastic vessels during one procedure. The duration of skin healing amounted to 2-4 weeks. There were neither ocular injuries or pronounced skin side effects nor relapses within 24 months after the laser procedure. Conclusion: CVL treatment of periorbital BCC provides relevant cosmetic results without ocular injuries and relapses.

show abstract

Section: Discussionmentioning

confidence: 85%

Treatment of Basal Cell Cancer With a Pulsed Copper Vapor Laser: A Case Series

Ponomarev

Topchiy

et al. 2019

J Lasers Med Sci

View full text Add to dashboard Cite

show abstract

Case of basal cell skin cancer: early debut, untimely diagnosis

Tseboeva¹,

Tsarueva²,

TsKhurbaeva³

2020

Klin. dermatol. venerol.

View full text Add to dashboard Cite

Treatment of basal cell cancer in the periorbital area using a pulsed copper vapour laser

Klyuchareva

Ponomarev

Topchy

et al. 2018

Vestnik dermatologii i venerologii

View full text Add to dashboard Cite

An increase in life expectancy in developed countries is inevitably accompanied by an increase in the number of nonmelanoma skin diseases, which are primarily represented by basal cell cancer (BCC) occurring in elderly and old-age patients. The pathogenesis of such diseases is associated both with impaired proliferation and differentiation of the keratinocytes of the epidermal basal layer, as well as with the transformation of the vasculature in the papillary dermis in the vicinity of BCC. In recent years, such conditions have been increasingly treated using CO2 , neodymium, diode and pulsed-dye lasers. In many cases, these devices allow malignant BCC cells to be successfully eliminated. However, the use of near-infrared lasers in the periorbital area is limited due to a higher risk of damaging the organs of the visual system. Therefore, a search for new laser surgery methods that can be used for treating malignant skin tumours seems to be a prospective research direction.Methods. 3 male and 9 female patients diagnosed with primary BCC were treated using a copper vapour laser (Yakhroma-Med). The age of the patients varied from 34 to 77 years. Laser treatment was carried out in one session under the following irradiation parameters: the wavelength of 511 and 578 nm, the average power of up to 3 W and a series of 15 ns pulses. The pause between the pulses was 60 μs, with the exposure time ranging from 200 to 600 ms. The light spot diameter on the skin surface was 1 mm. The follow-up monitoring duration was 24 months.Results. In all the BCC patients, one session of copper vapour laser treatment allowed malignant cells in the disease area to be completely eliminated without relapses during 2 years after the therapy. The duration of skin healing in the irradiated area was 2 weeks in patients under the age of 40 years, compared to 3–4 weeks in elderly patients. After the treatment, short-term side effects, such as a slight edema, erythema and peeling, were observed.

show abstract

Basal cell carcinoma: new opportunities for pathogenetic therapy

Cited by 4 publications

References 3 publications

Treatment of Basal Cell Cancer With a Pulsed Copper Vapor Laser: A Case Series

Treatment of Basal Cell Cancer With a Pulsed Copper Vapor Laser: A Case Series

Case of basal cell skin cancer: early debut, untimely diagnosis

Treatment of basal cell cancer in the periorbital area using a pulsed copper vapour laser

Contact Info

Product

Resources

About