Basal cell carcinoma colonized by lentigo maligna melanoma, with perineural invasion by both neoplasms

Pérez-Pérez, Manuel; Umbría-Jiménez, Sebastián; Mora-Cabeza, Montserrat; Fernández‐Orland, Almudena; Ríos-Martín, Juan José

doi:10.1111/cup.13886

Cited by 3 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, uniformly retained 5-hmC staining in desmoplastic Spitz nevi and BAP1-deficient melanocytic nevi is very interesting and may reflect different genetic events in the development of these subsets of spitzoid melanocytic neoplasms. 10 In this respect, it would be interesting to fur-…”

Section: Epigenetic Marker Expression Is Of Limited Diagnostic Utilitmentioning

confidence: 99%

Epigenetic marker expression is of limited diagnostic utility in spitzoid melanocytic neoplasms

et al. 2020

View full text Add to dashboard Cite

Section: Epigenetic Marker Expression Is Of Limited Diagnostic Utilitmentioning

confidence: 99%

Epigenetic marker expression is of limited diagnostic utility in spitzoid melanocytic neoplasms

et al. 2020

View full text Add to dashboard Cite

Basal Cell Carcinoma With Perineural Invasion: A Systematic Review and Pooled Survival Analysis

Abushukur

Ibrahim

Cascardo

et al. 2022

View full text Add to dashboard Cite

BACKGROUND Perineural invasion (PNI) is considered a high-risk histopathologic feature in many skin cancers. Perineural invasion is a well-known poor prognostic factor of squamous cell carcinoma, but is poorly understood in the context of basal cell carcinoma (BCC). OBJECTIVE To analyze available demographic, clinical, and treatment data for BCC with PNI and the effect of these variables on recurrence patterns, disease progression, and cancer-specific mortality (CSM). METHODS A systematic review and pooled-survival analysis was performed using case reports and series of patients with perineural BCC. RESULTS This review included 159 patients from 49 publications. Of these cases, 57 patients reported at least one recurrence. Where reported, median follow-up time was 31 months for patients without recurrence (n 5 79) and 21 months for patients with recurrence (n 5 32). The cumulative incidence of CSM at 5 years was 8.5% (95% confidence interval [CI] 0.028-0.186) and the overall five-year survival was 90.9% (95% CI 0.796-0.961). CONCLUSION Male gender, multifocal nerve involvement, presence of clinical symptoms, and PNI detected on imaging are associated with poor prognosis of BCC with PNI. The high rate of disease recurrence and suboptimal cumulative incidence of CSM highlights the importance of early clinical detection, before the onset of symptomatic PNI and multifocal nerve involvement.

show abstract

The Role of Extracellular Vesicles in Cancer–Nerve Crosstalk of the Peripheral Nervous System

Guo

Gil

2022

Cells

View full text Add to dashboard Cite

Although the pathogenic operations of cancer–nerve crosstalk (e.g., neuritogenesis, neoneurogensis, and perineural invasion—PNI) in the peripheral nervous system (PNS) during tumorigenesis, as well as the progression of all cancer types is continuing to emerge as an area of unique scientific interest and study, extensive, wide-ranging, and multidisciplinary investigations still remain fragmented and unsystematic. This is especially so in regard to the roles played by extracellular vesicles (EVs), which are lipid bilayer-enclosed nano- to microsized particles that carry multiple-function molecular cargos, facilitate intercellular communication in diverse processes. Accordingly, the biological significance of EVs has been greatly elevated in recent years, as there is strong evidence that they could contribute to important and possibly groundbreaking diagnostic and therapeutic innovations. This can be achieved and the pace of discoveries accelerated through cross-pollination from existing knowledge and studies regarding nervous system physiology and pathology, as well as thoroughgoing collaborations between oncologists, neurobiologists, pathologists, clinicians, and researchers. This article offers an overview of current and recent past investigations on the roles of EVs in cancer–nerve crosstalk, as well as in neural development, physiology, inflammation, injury, and regeneration in the PNS. By highlighting the mechanisms involved in physiological and noncancerous pathological cellular crosstalk, we provide hints that may inspire additional translational studies on cancer–nerve interplay.

show abstract

Basal cell carcinoma colonized by lentigo maligna melanoma, with perineural invasion by both neoplasms

Cited by 3 publications

References 9 publications

Epigenetic marker expression is of limited diagnostic utility in spitzoid melanocytic neoplasms

Epigenetic marker expression is of limited diagnostic utility in spitzoid melanocytic neoplasms

Basal Cell Carcinoma With Perineural Invasion: A Systematic Review and Pooled Survival Analysis

The Role of Extracellular Vesicles in Cancer–Nerve Crosstalk of the Peripheral Nervous System

Contact Info

Product

Resources

About