Basal and stress-induced corticosterone secretion is decreased by lesion of mesencephalic dopaminergic neurons

Casolini, Paola; Kabbaj, Mohamed; Leprat, F.; Piazza, Pier Vincenzo; ́-Pont, Françoise Rouge; Angelucci, L.; Simon, H.; Moal, Michel Le; Maccari, Stefania

doi:10.1016/0006-8993(93)90836-c

Cited by 49 publications

(20 citation statements)

References 32 publications

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“…Administration of a D 1 or D 2 agonist, or the DA uptake inhibitor GBR 12909 into the third ventricle or the paraventricular nucleus of the hypothalamus (but not into the lateral ventricle), stimulated the HPA axis Kuhn 1992, 1993). In addition, Casolini et al (1993) have reported that both basal and stressinduced corticosterone secretion is reduced by lesioning the ventral segmental area, the origin of the mesolimbic dopaminergic system. Furthermore, as mentioned earlier, the ventral striatum has been reported to play an important role mediating the corticosterone secretion induced by combined administration of D 1 D 2 agonists (SKF 38393/quinpirole) in rats (Ikemoto and Goeders 1998).…”

Section: Da Receptors Mediating Hormone Responses To Apomentioning

confidence: 99%

The Blunted Plasma Cortisol Response to Apomorphine and Its Relationship to Treatment Response in Patients with Schizophrenia

Meltzer

Lee

Jayathilake

2001

Neuropsychopharmacology

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Section: Da Receptors Mediating Hormone Responses To Apomentioning

confidence: 99%

The Blunted Plasma Cortisol Response to Apomorphine and Its Relationship to Treatment Response in Patients with Schizophrenia

Meltzer

Lee

Jayathilake

2001

Neuropsychopharmacology

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“…Nonetheless, PFC appears to participate in a variety of cognitive, affective, and physiological processes in both primates and rodents (Diorio et al, 1993;GoldmanRakic, 1987;McGregor et al, 1991;Neafsey, 1990;Sutton and Davidson, 1997). At least some of the behavioral and physiological functions of PFC appear to be modulated in stress, as well as by DA (Arnsten and Goldman-Rakic, 1998;Brozoski et al, 1979;Carlson et al, 1996;Casolini et al, 1993;Diorio et al, 1993;Murphy et al, 1996;Neafsey, 1990;Ravard et al, 1990;Sawaguchi and Goldman-Rakic, 1991;Sullivan and Szechtman, 1995;Zahrt et al, 1997).…”

Section: Behavioral and Physiological Significance Of Chewing-inducedmentioning

confidence: 99%

“…Evidence indicates that DA acts within the PFC to modulate at least a subset of these (Brozoski et al, 1979;Casolini et al, 1993;Jentsch et al, 1997aJentsch et al, , 1997bMurphy et al, 1996;Sawaguchi and Goldman-Rakic, 1991;Sullivan and Szechtman, 1995;Zahrt et al, 1997). Further, the anxiolytic benzodiazepines attenuate stressor-induced activation of the PFC DA system, whereas, the anxiogenic benzodiazepine inverse agonists (e.g., ␤-carbolines) increase PFC DA utilization (Lavielle et al, 1978;Roth, 1985, 1990).…”

Section: Introductionmentioning

confidence: 99%

Engagement in a non-escape (displacement) behavior elicits a selective and lateralized suppression of frontal cortical dopaminergic utilization in stress

Berridge

Mitton

Clark

et al. 1999

Synapse

107

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Although the preferential activation of the prefrontal cortical (PFC) dopaminergic system is generally observed in stress, limited exceptions to this have been observed. Certain non-escape behaviors have been demonstrated to attenuate physiological indices of stress (e.g., coping or displacement responses). One well-characterized non-escape behavior observed in stress is chewing, or gnawing, of inedible objects. Engagement in this behavior attenuates stress-related activation of the hypothalamopituitary-adrenal axis, in a variety of species. We examined the degree to which engagement in this non-escape behavior modulates stressor-induced activation of the PFC dopamine (DA) system. Rats and mice were exposed to a brightly lit novel environment (novelty stress) in the presence or absence of inedible objects. Following novelty exposure, various dopaminergic terminal fields were collected and dopamine and its major catabolite, DOPAC, were measured using HPLC with electrochemical detection. DOPAC/DA ratios were calculated as an index of DA utilization. In some cases serotonin (5-HT) and its major catabolite, 5-HIAA, were also measured. In animals that did not chew, novelty exposure elicited significant increases in DOPAC/DA levels within PFC, nucleus accumbens (shell and core subdivisions), and striatum (relative to quiet-controls). DOPAC/DA responses were greater in the right PFC than in the left PFC. Animals that chewed displayed significantly lower DOPAC/DA responses in PFC, but not other dopaminergic terminal fields. This effect of chewing was always observed in the right PFC and less consistently in the left PFC. Chewing did not alter novelty-induced increases in PFC 5-HIAA/5-HT responses. Thus, engagement in this non-escape behavior elicits a neuroanatomically and neurochemically specific attenuation of the PFC DA response in stress. Given the pivotal role of the PFC in certain cognitive and affective processes, behavioral regulation of PFC DA utilization may modulate cognitive and/or affective function in stress.

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“…Therefore, it is conceivable that an increased dopamine reactivity is related to the re ported elevation in CRH mRNA levels and subsequently ACTH release at the time that PRL is inhibited. Indeed, such a stimulatory role of the dopamine system on CRH release has been suggested, as basal and stress-induced corticoste rone levels were reduced after neurotoxic lesioning of the mesencephalic dopamine neurons with 6-hydroxy dopamine (23).…”

Section: Discussionmentioning

confidence: 99%

Divergent prolactin and pituitary-adrenal activity in rats selectively bred for different dopamine responsiveness.

Rots¹,

Cools²,

Oitzl³

et al. 1996

Endocrinology

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The present study explores the significance of brain dopamine phenotype for individual variation in the neuroendocrine stress re sponse of the rat. For this purpose, we used two W istar ra t lines previously selected for high or low responsiveness of the dopamine system to apomorphine using the gnawing response as the selection criterion, Systemic administration of the drug evoked in apomorphine-susceptible (apo-sus) rats a vigorous gnawing response, whereas apomorphine-unsusceptible (apo-unsus) rats did not gnaw under these conditions. These two rat lines represent individuals displaying extreme differences in gnawing behavior th at otherwise coexist in a normal Wistar population. In this study basal and stressinduced hypothalamic-pituitary-adrenal activity and PRL release were m easured in chronically cannulated, freely moving rats that endured a conditioned emotional response. Tyrosine hydroxylase messenger RNA (mRNA), corticosteroid receptor mRNA, and in vivo retention of [3H]corticosterone were measured in ra t brain sections using in situ hybridization and in vivo autoradiography.The results show th at 1) apo-sus rats had a markedly reduced PRL response to stress compared to apo-unsus animals, whereas basal levels were not significantly different. A12 dopaminergic neurons in the arcuate nucleus expressed significantly higher levels of tyrosine hydroxylase mRNA in apo-sus rats, suggesting th at the reduced stress-induced PRL release could be due to an increased inhibitory R ECENT STUDIES have shown that dopamine is linked to stress. For instance, stress induces a PRL response, and this release of PRL is under inhibitory control of dopa mine (1-3). Furthermore, rats with a predisposition to de velop amphetamine self-administration display prolonged adrenocortical activation and increased locomotor activity after exposure to the stress of novel environment (4-6). Glu cocorticoids promote activation and sensitization of the as cending dopaminergic neurons. Moreover, dopaminergic ac tivation of CRH neurons may occur (7,8). The data add to a growing body of evidence suggesting adverse effects of ab errant corticosteroid hormone signaling on dopaminedependent psychopathology; including psychoses precipi tated by excess glucocorticoids and stress. The susceptibility control by dopaminergic neurons; 2) in apo-sus rats, stress resulted in a sustained elevation of ACTH and free corticosterone levels, whereas the total corticosterone levels were not different between the two ra t lines; 3) under basal morning conditions, apo-sus ra ts had significantly higher plasm a ACTH, but, in contrast, lower free cor ticosterone than apo-unsus rats; total plasm a corticosterone levels were not different; 4) the basal evening ACTH level was elevated in apo-sus rats; after removal of the adrenals in the morning, this in creased ACTH level in apo-sus rats persisted into the afternoon 6 h postadrenalectomy; and 5) hippocampal mineralocorticoid (MR), but not glucocorticoid (GR), receptor capacity w as increased in apo-sus rats...

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Basal and stress-induced corticosterone secretion is decreased by lesion of mesencephalic dopaminergic neurons

Cited by 49 publications

References 32 publications

The Blunted Plasma Cortisol Response to Apomorphine and Its Relationship to Treatment Response in Patients with Schizophrenia

The Blunted Plasma Cortisol Response to Apomorphine and Its Relationship to Treatment Response in Patients with Schizophrenia

Engagement in a non-escape (displacement) behavior elicits a selective and lateralized suppression of frontal cortical dopaminergic utilization in stress

Divergent prolactin and pituitary-adrenal activity in rats selectively bred for different dopamine responsiveness.

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