Basal and Stimulated Calcitonin and Procalcitonin by Various Assays in Patients with and without Medullary Thyroid Cancer

Kratzsch, Jürgen; Petzold, Anne; Raue, Friedhelm; Reinhardt, Walter; Bröcker-Preuβ, Martina; Görges, Rainer; Mann, Klaus; Karges, Wölfram; Morgenthaler, Nils G.; Luster, Markus; Reiners, Christoph; Thiery, Joachim; Dralle, Henning; Führer, Dagmar

doi:10.1373/clinchem.2010.151688

Cited by 74 publications

(66 citation statements)

References 23 publications

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“…The number of spuriously increased basal PCT concentrations in those patients was lower than the number of increased CT concentrations as measured by 3 methods. Indeed, PCT concentrations <0.25 μg/L accurately excluded MTC in such patients 24. In a prospective study from our group,25 CT was measured in a consecutive series of 1236 patients carrying thyroid nodules, and 14 cases displayed increased CT levels (ie, >10 μg/L) and were selected for a pentagastrin stimulation test.…”

Section: Introductionmentioning

confidence: 99%

Procalcitonin measurement to screen medullary thyroid carcinoma: A prospective evaluation in a series of 2705 patients with thyroid nodules

Giovanella

Imperiali

Piccardo

et al. 2018

Eur J Clin Investigation

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BackgroundTo prospectively evaluate the role of procalcitonin (PCT) in screening of patients with thyroid nodules for medullary thyroid carcinoma (MTC).Materials and methodsWe measured PCT in 2705 patients with thyroid nodules referred to our centre between January 2011 and December 2017. Those with a positive PCT were operated after positive confirmatory tests such as fine‐needle aspiration, measurement of calcitonin (CT) in serum and fine‐needle aspiration washouts or CT stimulation testing. Patients with a negative PCT were operated based on the results of further diagnostics. The diagnostic performance of PCT was evaluated, and the best cut‐off level was selected by ROC curve analysis.ResultsAmong 2705 patients, 9 with positive serum PCT (ie, above 0.1 μg/L) and 370 with negative PCT underwent thyroid surgery. MTC was histologically confirmed in all patients with positive PCT but not found in patients with negative PCT. Serum PCT levels were significantly higher in patients with MTC (median 0.64 μg/L, range 0.16‐12.9 μg/L) than in those without (median 0.075 μg/L, range 0.075‐0.16 μg/L; P < .0001). ROC curves were plotted to calculate the optimal PCT value separating patients with MTC from those without. The best cut‐off was 0.155 μg/L with sensitivity, specificity, positive and negative predictive values as well as accuracy of 100%, 99.7%, 91.7%, 100% and 99.7%, respectively. Positive and negative likelihood ratios were 329 and zero, respectively.ConclusionsMeasurement of PCT is a sensitive and accurate method for detecting MTC in patients with thyroid nodules and can thus be a reliable alternative to CT measurement.

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Section: Introductionmentioning

confidence: 99%

Procalcitonin measurement to screen medullary thyroid carcinoma: A prospective evaluation in a series of 2705 patients with thyroid nodules

Giovanella

Imperiali

Piccardo

et al. 2018

Eur J Clin Investigation

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“…The titles and abstracts of these articles were reviewed, and nine original papers were selected; their fulltext versions were then retrieved, and their references lists were scanned (Bihan et al 2003, Bolko et al 2003, Algeciras-Schimnich et al 2009, Kaczka et al 2010, 2012, Walter et al 2010, Kratzsch et al 2011, Giovanella et al 2013, Machens et al 2014. These papers were published from 2003 to 2014, and they were all original articles (Table 1).…”

Section: Eligible Articlesmentioning

confidence: 99%

“…These papers were published from 2003 to 2014, and they were all original articles (Table 1). Almost all of the studies were from European researchers (Bihan et al 2003, Bolko et al 2003, Kaczka et al 2010, 2012, Walter et al 2010, Kratzsch et al 2011, Giovanella et al 2013, Machens et al 2014, and one was conducted by US investigators (Algeciras-Schimnich et al 2009). Some of these studies used ProCT (Bihan et al 2003, Giovanella et al 2013, Machens et al 2014 in the preoperative diagnosis of MTC, whereas the remaining ones (Bihan et al 2003, Bolko et al 2003, Kaczka et al 2010, 2012, Walter et al 2010, Kratzsch et al 2011 measured ProCT during follow-up of patients who had been previously treated for MTC.…”

Section: Eligible Articlesmentioning

confidence: 99%

“…For CT measurement, different assays were employed and different reference values were adopted. Preoperative ProCT stimulation by pentagastrin was performed in two studies (Kratzsch et al 2011, Giovanella et al 2013. The different characteristics between the studies (i.e., objective, ProCT cutoff level, etc.)…”

Section: Eligible Articlesmentioning

confidence: 99%

“…Seven papers (Bihan et al 2003, Bolko et al 2003, Algeciras-Schimnich et al 2009, Kaczka et al 2010, 2012, Walter et al 2010, Kratzsch et al 2011 reported ProCT measurement in MTC patients during follow-up after surgery. A total of 265 MTC cases, of which 114 involved cured patients and 151 were recurrent/persistent cases, were reported.…”

Section: Use Of Proct For the Postoperative Detection Of Recurrent Mtcmentioning

confidence: 99%

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Procalcitonin for detecting medullary thyroid carcinoma: a systematic review

Trimboli¹,

Seregni²,

Treglia³

et al. 2015

Endocrine-Related Cancer

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The aim of the present study was to perform a systematic review of published studies to provide a robust estimation of the use of procalcitonin (ProCT) as a diagnostic marker of medullary thyroid carcinoma (MTC), with particular focus on its specificity and negative predictive value in excluding MTC. A comprehensive computer literature search was conducted to find relevant published articles on the topic. We used a search algorithm based on a combination of the terms 'medullary,' 'thyroid,' and 'ProCT.' The search was updated until February 2015. To expand our search, references of the retrieved articles were also screened. A total of 39 articles were retrieved, of which nine original papers published from 2003 to 2014 were selected for the review. Some of these studies used ProCT in the preoperative diagnosis of MTC, whereas others measured ProCT during the follow-up of patients who had been previously treated for MTC. Other laboratory measurements were performed in some of the included studies. The results of the majority of the studies indicate that ProCT measurement appears to be a very promising and reliable serum marker for the diagnosis of MTC, and it is not inferior to calcitonin (CT). The sample handling is less laborious, and in the few CT-negative cases reviewed, the assay had even greater sensitivity. It would be worthwhile to establish cutoff levels using larger patient series, because we speculate that this assay could potentially replace CT measurement in the future.

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Calcitonin testing for detection of medullary thyroid cancer in people with thyroid nodules

Verbeek

Groot

Sluiter

et al. 2020

Cochrane Database of Systematic Reviews

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Basal and Stimulated Calcitonin and Procalcitonin by Various Assays in Patients with and without Medullary Thyroid Cancer

Cited by 74 publications

References 23 publications

Procalcitonin measurement to screen medullary thyroid carcinoma: A prospective evaluation in a series of 2705 patients with thyroid nodules

Procalcitonin measurement to screen medullary thyroid carcinoma: A prospective evaluation in a series of 2705 patients with thyroid nodules

Procalcitonin for detecting medullary thyroid carcinoma: a systematic review

Calcitonin testing for detection of medullary thyroid cancer in people with thyroid nodules

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