Basal and Postprandial Serum Levels of Gastrin in Normotensive and Hypertensive Adults

Jiang, Xia; Wang, Wenjie; Ning, Bin; Liu, Xing; Gong, Jian; Gan, Fusheng; Gao, Xuezhong; Zhang, Lianfeng; José, Pedro A.; Qin, Chuan; Yang, Zhiwei

doi:10.3109/10641963.2012.690474

Cited by 17 publications

(23 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, in hypertensive patients, fasting serum gastrin levels were inversely correlated with blood pressure, suggesting that gastrin is involved in the regulation of blood pressure 7, 32. Our laboratory found that the intrarenal infusion of gastrin induces natriuresis and diuresis 8.…”

Section: Discussionmentioning

confidence: 76%

“…Increased postprandial gastrin levels have been associated with a postprandial decrease of blood pressure in hypertensive patients 7. Moreover, in hypertensive patients, fasting serum gastrin levels were inversely correlated with blood pressure, suggesting that gastrin is involved in the regulation of blood pressure 7, 32.…”

Section: Discussionmentioning

confidence: 99%

“…The blood level of gastrin markedly increases after a meal, ≈10‐ to 20‐fold more than cholecystokinin 6. The postprandial increase in serum gastrin level is associated with the postprandial decrease in blood pressure in hypertensive but not normotensive adults 7. Our previous study showed that a synergistic interaction between renal CCK2R (cholecystokinin 2 receptor) and D 1 ‐like dopamine receptors plays a pivotal role in maintaining normal blood pressure 8.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gastrin Protects Against Myocardial Ischemia/Reperfusion Injury via Activation of RISK (Reperfusion Injury Salvage Kinase) and SAFE (Survivor Activating Factor Enhancement) Pathways

Yang

Yue

Zhang

et al. 2018

JAHA

Self Cite

View full text Add to dashboard Cite

BackgroundIschemia/reperfusion injury (IRI) is one of the most predominant complications of ischemic heart disease. Gastrin has emerged as a regulator of cardiovascular function, playing a key protective role in hypoxia. Serum gastrin levels are increased in patients with myocardial infarction, but the pathophysiogical significance of this finding is unknown. The purpose of this study was to determine whether and how gastrin protects cardiac myocytes from IRI.Methods and ResultsAdult male Sprague‐Dawley rats were used in the experiments. The hearts in living rats or isolated Langendorff‐perfused rat hearts were subjected to ischemia followed by reperfusion to induce myocardial IRI. Gastrin, alone or with an antagonist, was administered before the induction of myocardial IRI. We found that gastrin improved myocardial function and reduced the expression of myocardial injury markers, infarct size, and cardiomyocyte apoptosis induced by IRI. Gastrin increased the phosphorylation levels of ERK1/2 (extracellular signal‐regulated kinase 1/2), AKT (protein kinase B), and STAT3 (signal transducer and activator of transcription 3), indicating its ability to activate the RISK (reperfusion injury salvage kinase) and SAFE (survivor activating factor enhancement) pathways. The presence of inhibitors of ERK1/2, AKT, or STAT3 abrogated the gastrin‐mediated protection. The protective effect of gastrin was via CCK2R (cholecystokinin 2 receptor) because the CCK2R blocker CI988 prevented the gastrin‐mediated protection of the heart with IRI. Moreover, we found a negative correlation between serum levels of cardiac troponin I and gastrin in patients with unstable angina pectoris undergoing percutaneous coronary intervention, suggesting a protective effect of gastrin in human cardiomyocytes.ConclusionsThese results indicate that gastrin can reduce myocardial IRI by activation of the RISK and SAFE pathways.

show abstract

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gastrin Protects Against Myocardial Ischemia/Reperfusion Injury via Activation of RISK (Reperfusion Injury Salvage Kinase) and SAFE (Survivor Activating Factor Enhancement) Pathways

Yang

Yue

Zhang

et al. 2018

JAHA

Self Cite

View full text Add to dashboard Cite

show abstract

“…Gastrin is a peptide hormone, which regulates gastric acid secretion and exerts physiological actions such as the regulation of sodium balance (29). Gastrin has been suggested to be involved in blood pressure regulation, possibly via the regulation of sodium and water metabolism and/or the renin-angiotensin-aldosterone system (29).…”

Section: Discussionmentioning

confidence: 99%

“…Gastrin has been suggested to be involved in blood pressure regulation, possibly via the regulation of sodium and water metabolism and/or the renin-angiotensin-aldosterone system (29). Measurements of gastrin levels are taken primarily for the diagnosis of gastrin-producing tumors (gastrinomas), which cause Zollinger-Ellison syndrome.…”

Section: Discussionmentioning

confidence: 99%

Changes in FABP1 and gastrin receptor expression in the testes of rats that have undergone electrical injury

Huang

Liu

2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Testicular trauma may occur due to accidental electrical injury. The aim of this study was to investigate alterations in the levels of fatty acid-binding protein 1 (FABP1) and gastrin receptor (gastrin R) in the testes following electrical injury. Sprague-Dawley rats were divided into control, fatal electrocution (220 V, 50 Hz, 60 sec) and electrical injury (220 V, 50 Hz, 60 sec) groups (n=8 per group). The animals in the fatal electrocution and electrical injury groups were deeply anesthetized with sodium pentobarbital prior to each treatment, in which the current was delivered via an anode connected to the left foreleg and a cathode to the right hindleg. The rats that survived were subsequently sacrificed by cervical dislocation. Control animals received cervical dislocation alone. Immunohistochemical analysis was performed to evaluate the protein expression of FABP1 and gastrin R in the testes. Sections were evaluated by digital image analysis. The expression levels of FABP1 and gastrin R were significantly increased following electrical injury, supported by an increase in the integrated optical density (IOD) when compared with that in the control group (P<0.05). However, no significant difference was found in FABP1 and gastrin R expression levels between the fatal electrocution and control groups. In summary, the protein expression levels of FABP1 and gastrin R were found to be significantly altered by electrical injury, suggesting that these two proteins may be important in underlying mechanisms of testicular injury during electrical injury. The findings indicate that such alterations would be reflected in abnormal testicular function.

show abstract

Alterations of rat stomach endocrine cells under renovascular hypertension

Kasacka

Piotrowska

Lewandowska

2014

Advances in Medical Sciences

View full text Add to dashboard Cite

Basal and Postprandial Serum Levels of Gastrin in Normotensive and Hypertensive Adults

Cited by 17 publications

References 32 publications

Gastrin Protects Against Myocardial Ischemia/Reperfusion Injury via Activation of RISK (Reperfusion Injury Salvage Kinase) and SAFE (Survivor Activating Factor Enhancement) Pathways

Gastrin Protects Against Myocardial Ischemia/Reperfusion Injury via Activation of RISK (Reperfusion Injury Salvage Kinase) and SAFE (Survivor Activating Factor Enhancement) Pathways

Changes in FABP1 and gastrin receptor expression in the testes of rats that have undergone electrical injury

Alterations of rat stomach endocrine cells under renovascular hypertension

Contact Info

Product

Resources

About