Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension

Behuliak, Michal; Bencze, Michal; Vaněčková, Ivana; Kuneš, Jaroslav; Zicha, Josef

doi:10.1155/2017/8029728

Cited by 18 publications

(13 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under such conditions fasudil elicited greater BP reduction in normotensive Hannover Sprague Dawley controls than in hypertensive TGR. These findings indicate attenuated calcium sensitization not only in TGR (Behuliak et al 2017, Vaněčková et al 2019 but also in iTGR (this study).…”

supporting

confidence: 71%

The absence of sympathoexcitation during the development of hypertension in Cyp1a1 Ren-2 transgenic rats

Zicha

Hojná²,

Kopkan³

et al. 2019

Physiol Res

View full text Add to dashboard Cite

The insertion of mouse renin gene (Ren-2) into the genome of normotensive rats causes a spontaneous rise of blood pressure (BP), leading to an angiotensin II (Ang II)-dependent form of hypertension in transgenic (mRen-2)27 rats (TGR). However, enhanced sympathetic BP component was demonstrated in heterozygous TGR aged 20 weeks. In the present study we used another model, i.e. Cyp1a1-Ren-2 transgenic rats (iTGR) in which hypertension can be induced by natural xenobiotic indole-3 carbinol (I3C) added to the diet. We investigated whether the development of high blood pressure (BP) in 5-month-old iTGR animals fed I3C diet for 10 days is solely due to enhanced Ang II-dependent vasoconstriction or whether enhanced sympathetic vasoconstriction also participates in BP maintenance in this form of hypertension. Using acute sequential blockade of renin-angiotensin system (RAS), sympathetic nervous system (SNS) and NO synthase (NOS) we have demonstrated that the observed gradual increase of BP in iTGR fed I3C diet was entirely due to the augmentation of Ang II-dependent BP component without significant changes of sympathetic BP component. Thus, the hypertension in iTGR resembles to that of homozygous TGR in which high BP was entirely dependent on Ang II-dependent vasoconstriction. Moreover, our measurements of acute BP response to Rho kinase inhibitor fasudil in animals subjected to a combined blockade of RAS, SNS and NOS indicated the attenuation of basal calcium sensitization in both iTGR and homozygous TGR.

show abstract

supporting

confidence: 71%

The absence of sympathoexcitation during the development of hypertension in Cyp1a1 Ren-2 transgenic rats

Zicha

Hojná²,

Kopkan³

et al. 2019

Physiol Res

View full text Add to dashboard Cite

show abstract

“…Strong substantiations on molecules, animals and humans is based on the association between calcium consumption and the occurrence of cardiovascular disease. A clinical trial in rats has shown that sensitization of basal and active calcium has a mediating effect on genetic and induced hypertension [17]. This study suggests a probable association between ingested calcium and hypertension.…”

Section: Introductionmentioning

confidence: 51%

Rural and Urban Population Differences in the Association of Dietary Calcium with Blood Pressure and Hypertension Occurrence: Analysis of Longitudinal Data from the China Health and Nutrition Survey

Nkondjock

Martin

et al. 2020

View full text Add to dashboard Cite

The relationship of dietary calcium intake (DCI) to blood pressure (BP) and hypertension occurrence (HTN) in the general population is controversial. Few studies have reported the impact of DCI on high blood pressure (HBP) and HTN in rural and urban populations (RPs and UPs, respectively). In this study, we assessed how DCI is related to BP and HTN among the RP and the UP. This retrospective study used data from the Chinese Health and Nutrition Survey (CHNS) for 2000–2009. We analyzed 12,052 records from 3013 participants using path analysis and logistic regressions. DCI and HTN were significantly higher in the UP compared to the RP. When UPs and RPs were analyzed together, a 1 unit increase in DCI decreased systolic blood pressure (SBP) by 0.01 (p = 0.002) but had no effect on diastolic blood pressure. Males vs. females from the RP presented significant risk of HTN by the high DCI (OR = 2.3 (1.6–3.6)). DCI and its association with BP varied based on living environment and sex.

show abstract

“…The Mayo Clinic also recommends exercising regularly and eating a healthy diet with plentiful whole grains, fruits, and vegetables. Reducing your salt intake can also have a profound impact in terms of lowering your blood pressure (Behuliak et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

MOL2NET: FROM MOLECULES TO NETWORKS (PROCEEDINGS BOOK), 2017, 3rd edition.

Gonzalez-Diaz

Arrasate

Sotomayor

et al. 2018

Proceedings of MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd Edition

View full text Add to dashboard Cite

Welcome from the Conference ChairWe are glad to invite all colleagues worldwide to participate on a new edition of this International Conference Series. The official title of this conference series is MOL2NET International Conference Series on Multidisciplinary Sciences. This is a scientific conference series running on a year-round conference scheme (opened for submissions and publications almost all the year) in order to fit on the same platform 3 general sections and more than 10 associate workshops worldwide (see schedule bellow). (1) Submit the title and abstract, select a section or workshop (do not upload paper here) [Submit New Abstract] (2) Wait for Sciforum abstract acceptance email, follow the link, and/or login to upload paper, doc and pdf format (3) Download template doc and prepare your communication [Template File] (4) Wait for paper acceptance and publication emails (follow link to proofread your paper) (Asap after upload) (5) Communicate with chairpersons if corrections are necessary, including past editions (All the year) (6) Log in to post comments, questions, or answers in a section or one of the workshops Schedule for Online participation: After publication of papers is closed we open the online platform for online participation. The authors will be able to post online comments and/or answers to comments in this workshop/section and also in the other general sections and/or >10 international workshops of the MOL2NET conference (many of them also run both online and in person). The participants are entitled to receive participation certificates for MOL2NET conference and all the workshops they participate upon request to the respective chairpersons. See committees of MOL2NET and each workshop.Schedule for in person participation: Many of the workshops associated to MOL2NET are going to be held also in person (face-toface) in different universities of USA, Spain, Italy, Mexico, Chile, etc. This in person workshops have specific schedules in parallel to their online versions. Please, go to the homepages of these workshops and/or contact their chairpersons for further details.Notes for participants MOL2NET conference runs both online (general sections) and/or in person (associated workshops). No physical presence is needed for online participation saving traveling costs. We accept experimental works, theoretical works, or experimental-theoretic works in the areas mentioned. Proceedings will be Published Online, Open Access, and Totally Free of Charges (no cost). For details about in person (face-to-face) participation on associated workshops contact the respective members of the local committees.Before to submit your communication recommend to download and use the [Template File] to write your communication; we strongly recommend you to read carefully the following notes to participants about publication model, copyright, authors responsibilities, etc Firstly, be aware that the works published here belongs to two main modalities preliminary communications or comments on previous works.Prel...

show abstract

Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension

Cited by 18 publications

References 54 publications

The absence of sympathoexcitation during the development of hypertension in Cyp1a1 Ren-2 transgenic rats

The absence of sympathoexcitation during the development of hypertension in Cyp1a1 Ren-2 transgenic rats

Rural and Urban Population Differences in the Association of Dietary Calcium with Blood Pressure and Hypertension Occurrence: Analysis of Longitudinal Data from the China Health and Nutrition Survey

MOL2NET: FROM MOLECULES TO NETWORKS (PROCEEDINGS BOOK), 2017, 3rd edition.

Contact Info

Product

Resources

About