Abstract:We and others have shown that the molecular signatures of diverse bacterial species accumulate in human atheromatous lesions. Here, we aimed to determine the effect of non-viable bacteria on foam cell formation in vitro. Using human monocyte-derived macrophages and the murine J774 macrophage cell line, we found that any of a diverse panel of heat-killed Gram-positive or Gram-negative bacteria shown previously to accumulate in human atherosclerotic lesions promoted marked induction of foam cell formation in mac… Show more
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