Bartonella vinsonii subsp. berkhoffii and Bartonella henselae as potential causes of proliferative vascular diseases in animals

Beerlage, Christiane; Varanat, Mrudula; Linder, K. L.; Maggi, Ricardo G.; Cooley, Jim; Kempf, Volkhard A. J.; Breitschwerdt, Edward B.

doi:10.1007/s00430-012-0234-5

Cited by 48 publications

(50 citation statements)

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“…DNA in dogs with splenic disease, mainly vasoproliferative tumor-like lesions, was unexpected in our investigation. Molecular evidence supports that four species of Bartonella , alone or in co-infection, could potentially induce vasoproliferative lesions [5]. Bartonella infection induces overlapping mechanisms in the development of vasoproliferative tumors, such as direct mitogenic effect on endothelial cells, inhibition of endothelial cell apoptosis and activation of hypoxia inducible factor-Iα, resulting in increased expression of the vascular endothelial growth factor [25–28].…”

Section: Discussionmentioning

confidence: 99%

“…Substantial evidence supports that the spleen plays a key role in the immunopathology of CVBD [3]. However, the development of splenic disease in itself has also been anecdotally associated with the presence of VBP infections in dogs [4, 5]. …”

Section: Introductionmentioning

confidence: 99%

“…in dogs with fibrohistiocytic nodules (FHN) and hemangiosarcoma (HSA) in the spleen [4]. Mechanistic evidence as to how these bacteria contribute to the development of vasoproliferative lesions has been provided [5]. Additionally, splenic vasculitis, thrombosis and infarction, were recently documented in a febrile dog diagnosed with Bartonella henselae [20].…”

Section: Introductionmentioning

confidence: 99%

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Molecular detection of vector-borne pathogens in blood and splenic samples from dogs with splenic disease

et al. 2017

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BackgroundThe spleen is a highly perfused organ involved in the immunological control and elimination of vector-borne pathogens (VBP), which could have a fundamental role in the pathogenesis of splenic disease. This study aimed to evaluate certain VBP in samples from dogs with splenic lesions.MethodsSeventy-seven EDTA-blood and 64 splenic tissue samples were collected from 78 dogs with splenic disease in a Mediterranean area. Babesia spp., Bartonella spp., Ehrlichia/Anaplasma spp., Hepatozoon canis, Leishmania infantum, hemotropic Mycoplasma spp. and Rickettsia spp. were targeted using PCR assays. Sixty EDTA-blood samples from dogs without evidence of splenic lesions were included as a control group.ResultsMore than half (51.56%) of the biopsies (33/64) were consistent with benign lesions and 48.43% (31/64) with malignancy, mostly hemangiosarcoma (25/31). PCR yielded positive results in 13 dogs with spleen alterations (16.67%), for Babesia canis (n = 3), Babesia gibsoni (n = 2), hemotropic Mycoplasma spp. (n = 2), Rickettsia massiliae (n = 1) and “Babesia vulpes” (n = 1), in blood; and for B. canis, B. gibsoni, Ehrlichia canis and L. infantum (n = 1 each), in spleen. Two control dogs (3.3%) were positive for B. gibsoni and H. canis (n = 1 each). Benign lesions were detected in the 61.54% of infected dogs (8/13); the remaining 38.46% were diagnosed with malignancies (5/13). Infection was significantly associated to the presence of splenic disease (P = 0.013). There was no difference in the prevalence of infection between dogs with benign and malignant splenic lesions (P = 0.69); however B. canis was more prevalent in dogs with hemangiosarcoma (P = 0.006).ConclusionsVBP infection could be involved in the pathogenesis of splenic disease. The immunological role of the spleen could predispose to alterations of this organ in infected dogs. Interestingly, all dogs with B. canis infection were diagnosed with hemangiosarcoma in the present survey. As previously reported, results support that VBP diagnosis could be improved by analysis of samples from different tissues. The sample size included here warrants further investigation.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2074-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular detection of vector-borne pathogens in blood and splenic samples from dogs with splenic disease

et al. 2017

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“…should be investigated as a cause of vasoproliferative tumors in both humans and dogs, due to their ability of enhancing endothelial cell proliferation in conjunction with inhibition of apoptosis [13, 14]. Species of Bartonella involved are B. bacilliformis , B. quintana , B. henselae , B. vinsonii berkhoffi and B. koehlerae .…”

Section: Discussionmentioning

confidence: 99%

First description of Bartonella koehlerae infection in a Spanish dog with infective endocarditis

Tabar¹,

Altet²,

Maggi

et al. 2017

Parasites Vectors

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Background Bartonella koehlerae has been recently described as a new cat- and cat fleas-associated agent of culture-negative human endocarditis. It has been also encountered in one dog from Israel and six dogs from the USA, but other clinically relevant reports involving this bacterium are lacking.ResultsA 7-year-old intact male mixed dog presented with clinico-pathological signs consistent with mitral endocarditis and cutaneous hemangiosarcoma. Molecular studies revealed the presence of Bartonella koehlerae DNA in samples from blood and mitral valve tissue.ConclusionsThis is the first description of B. koehlerae in Spain, corroborating that it can also be detected in dogs. Bartonella koehlerae infection should also be considered in Spain in humans and dogs presenting with clinical disease suggestive of it, such as culture-negative endocarditis.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2188-3) contains supplementary material, which is available to authorized users.

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“…Ha sido propuesto que las células hematopoyéticas podrían transportar la bacteria a los tejidos periféricos, en particular, al endotelio de la microcirculación, donde iniciarían los desórdenes vasoproliferativos 2 . En animales como perros, lobos, caballos y gatos se han encontrado secuencias de ADN de B. henselae en tumores como hemangiopericitomas y angioendoteliomatosis 15,16 . Las manifestaciones de tumores vasoproliferativos por B. henselae más significativas en humanos son la angiomatosis bacilar y peliosis bacilar.…”

Section: Compromiso Por B Henselae De Snc Y Su Relación Con Patologíunclassified

Infección por Bartonella henselae con compromiso de sistema nervioso central, asociado a un papiloma del plexo coroídeo

Barnafi

Conca

Borries

et al. 2017

Rev. chil. infectol.

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Bartonella vinsonii subsp. berkhoffii and Bartonella henselae as potential causes of proliferative vascular diseases in animals

Cited by 48 publications

References 49 publications

Molecular detection of vector-borne pathogens in blood and splenic samples from dogs with splenic disease

Molecular detection of vector-borne pathogens in blood and splenic samples from dogs with splenic disease

First description of Bartonella koehlerae infection in a Spanish dog with infective endocarditis

Infección por Bartonella henselae con compromiso de sistema nervioso central, asociado a un papiloma del plexo coroídeo

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