Bartonella henselae infection in a man with hypergammaglobulinaemia, splenomegaly and polyclonal plasmacytosis

Balakrishnan, N.; Jawanda, Jaspaul S.; Miller, Melissa B.; Breitschwerdt, Edward B.

doi:10.1099/jmm.0.052134-0

Cited by 10 publications

(18 citation statements)

References 11 publications

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“…In contrast to the reservoir‐adapted host, the microbiological detection of a Bartonella spp. in a nonreservoir adapted host can be extremely difficult . Most, although not all, diseases caused by Bartonella spp.…”

Section: Introductionmentioning

confidence: 99%

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Bartonellosis, One Health and all creatures great and small

Breitschwerdt

2017

Veterinary Dermatology

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Background Bartonellosis is a zoonotic infectious disease of worldwide distribution, caused by an expanding number of recently discovered Bartonella spp. Objectives This review serves as an update on comparative medical aspects of this disease, including the epidemiology, pathogenesis, clinical diagnosis, treatment and challenges. Results Of comparative medical importance, Bartonella spp. are transmitted by several arthropod vectors, including fleas, keds, lice, sand flies, ticks and, potentially, mites and spiders. Prior to 1990, there was only one named Bartonella species (B. bacilliformis), whereas there are now over 36, of which 17 have been associated with an expanding spectrum of animal and human diseases. Recent advances in diagnostic techniques have facilitated documentation of chronic bloodstream and dermatological infections with Bartonella spp. in healthy and sick animals, in human blood donors, and in immunocompetent and immunocompromised human patients. The field of Bartonella research remains in its infancy and is rich in questions, for which patient relevant answers are badly needed. Directed Bartonella research could substantially reduce a spectrum of chronic and debilitating animal and human diseases, and thereby reduce suffering throughout the world. Conclusion A One Health approach to this emerging infectious disease is clearly needed to define disease manifestations, to establish the comparative infectious disease pathogenesis of this stealth pathogen, to validate effective treatment regimens and to prevent zoonotic disease transmission.

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Section: Introductionmentioning

confidence: 99%

“…Most, although not all, diseases caused by Bartonella spp. occur in accidental hosts and these organisms are being increasingly implicated as a cause of zoonotic infections . Mechanisms that facilitate persistent Bartonella bacteraemia in mammals remain incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

Bartonellosis, One Health and all creatures great and small

Breitschwerdt

2017

Veterinary Dermatology

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116

118

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“…Pathogen DNA amplification may be affected by the size of the tissue placed in formalin, the type of tissue, and the duration of formalin fixation before embedding. DNA degradation during formalin fixation has been well documented, especially in detecting B. henselae in splenic and skin tissues (N. Balakrishnan, Perdergraft JS, Kolluru S, Lappin M, Breitschwerdt EB, unpublished data). Additionally, low numbers of Bartonella within some of the inflammatory lesions or the history of antibiotic treatment may have mitigated the ability to detect bacterial pathogens in the other organs tested.…”

Section: Discussionmentioning

confidence: 99%

Pyogranulomatous Pancarditis with Intramyocardial Bartonella henselae San Antonio 2 (BhSA2) in a Dog

Donovan

Fox

Balakrishnan

et al. 2016

Veterinary Internal Medicne

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“…However, although successful in specific instances, PCR amplification of Bartonella spp. DNA from patients with chronic intravascular infections or patients with localized parenchymal tissue involvement of the liver, spleen, and kidney, which can contain low numbers of bacteria, is less sensitive (20,21). From a clinical or pathological perspective, it is important to realize that failure to amplify B. henselae DNA from this dog's intestinal and colonic biopsy specimens does not confirm that the bacteria did not infect these tissues, particularly as bloodstream infection was implicated simultaneously by PCR.…”

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confidence: 96%