Bartonella henselae Endocarditis: An Usual Presentation of an Unusual Disease

Shtaya, Aasem Abu; Perek, Shoshan; Kibari, Adi; Cohen, Shai

doi:10.12890/2019_001038

Cited by 9 publications

(11 citation statements)

References 6 publications

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“…A majority of cases of Bartonella IE have been reported from Europe and the Americas. However, cases from Asia, Africa, and Australia have been also documented, suggesting a worldwide distribution [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. In Europe, Bartonella spp.…”

Section: Discussionmentioning

confidence: 99%

Bartonella Endocarditis in Spain: Case Reports of 21 Cases

et al. 2022

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Blood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such as Bartonella spp. The aim of this study was to describe the epidemiologic, clinical characteristics, management and outcomes of patients with Bartonella IE from the “Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)”cohort. Here we presented 21 cases of Bartonella IE. This represents 0.3% of a total of 5590 cases and 2% of the BCNE from the GAMES cohort. 62% were due to Bartonella henselae and 38% to Bartonella quintana. Cardiac failure was the main presenting form (61.5% in B. hensalae, 87.5% in B. quintana IE) and the aortic valve was affected in 85% of the cases (76% in B. henselae, 100% in B. quintana IE). Typical signs such as fever were recorded in less than 40% of patients. Echocardiography showed vegetations in 92% and 100% of the patients with B. henselae and B. quintana, respectively. Culture was positive only in one patient and the remaining were diagnosed by serology and PCR. PCR was the most useful tool allowing for diagnosis in 16 patients (100% of the studied valves). Serology, at titers recommended by guidelines, only coincided with PCR in 52.4%. Antimicrobial therapy, in different combinations, was used in all cases. Surgery was performed in 76% of the patients. No in-hospital mortality was observed. One-year mortality was 9.4%. This article remarks the importance for investigating the presence of Bartonella infection as causative agent in all BCNE since the diagnosis needs specific microbiological tools and patients could benefit of a specific treatment.

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Section: Discussionmentioning

confidence: 99%

Bartonella Endocarditis in Spain: Case Reports of 21 Cases

et al. 2022

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“…Antimicrobial treatment of Bartonella spp.-associated diseases depends solely on the clinical situation and immunological status of the patient and less on the infective species. Consequently, no general treatment recommendation does exist for all Bartonella spp.-associated diseases [212,214].…”

Section: Salmonella Enterica Adhesin Amentioning

confidence: 99%

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

Thibau

Dichter

Vaca

et al. 2019

Med Microbiol Immunol

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The current problem of increasing antibiotic resistance and the resurgence of numerous infections indicate the need for novel vaccination strategies more than ever. In vaccine development, the search for and the selection of adequate vaccine antigens is the first important step. In recent years, bacterial outer membrane proteins have become of major interest, as they are the main proteins interacting with the extracellular environment. Trimeric autotransporter adhesins (TAAs) are important virulence factors in many Gram-negative bacteria, are localised on the bacterial surface, and mediate the first adherence to host cells in the course of infection. One example is the Neisseria adhesin A (NadA), which is currently used as a subunit in a licensed vaccine against Neisseria meningitidis. Other TAAs that seem promising vaccine candidates are the Acinetobacter trimeric autotransporter (Ata), the Haemophilus influenzae adhesin (Hia), and TAAs of the genus Bartonella. Here, we review the suitability of various TAAs as vaccine candidates.

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“…Tropheryma whipplei, Chlamydiophila, and Mycobacterium chimaera belong to the latter group 2 . Bartonella species are considered emergent pathogens in culture-negative IE with increasing reports in recent years [3][4][5][6][7][8][9][10] .…”

Section: Descripción De Dos Casos En Chilementioning

confidence: 99%

Infectious endocarditis by Bartonella species. Report of two cases

et al. 2019

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Infectious endocarditis (IE) by Bartonella species is an emerging problem worldwide. We report two cases of native valve Bartonella-associated IE events, both affecting adult male patients with a history of alcohol abuse and a low socioeconomic status. Admissions were due to pancytopenia and bleeding in one case and embolic stroke in the other. Blood cultures were negative and IgG indirect immunofluorescence assays (IFA) were positive for B. henselae/B. quintana in high titers (1/16,384-1/16,384, and 1/32,768-1/16,384, respectively). Cases were classified as definitive IE events according to modified Duke criteria due to the presence of valve vegetations with at least three minor criteria. One patient required aortic mechanical valve replacement and survived, and the other died after a massive hemorrhagic transformation of his stroke. PCR amplification and sequencing of the 16S ribosomal bacterial DNA from a valve tissue sample obtained at surgery in the patient who survived, confirmed B. quintana as the etiological agent. Bartonella-associated IE is an emerging problem in Chile, present in disadvantaged populations. It should be suspected in patients with culture-negative IE. IFA does not discriminate between B. henselae and B. quintana infection, but high titers suggest IE. Complementary PCR techniques may help to elucidate the final causative agent.

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Bartonella henselae Endocarditis: An Usual Presentation of an Unusual Disease

Cited by 9 publications

References 6 publications

Bartonella Endocarditis in Spain: Case Reports of 21 Cases

Bartonella Endocarditis in Spain: Case Reports of 21 Cases

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

Infectious endocarditis by Bartonella species. Report of two cases

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