Bartonella gabonensis sp. nov., a new bartonella species from savannah rodent Lophuromys sp. in Franceville, Gabon

Mangombi, Joa Braïthe; N’Dilimabaka, Nadine; Medkour, Hacène; Banga, O.L.; Tall, Mamadou Lamine; Khedher, Mariem Ben; Terras, Jérôme; Abdi, Souhila; Bourgarel, Mathieu; Leroy, Eric M.; Fénollar, Florence; Mediannikov, Oleg

doi:10.1016/j.nmni.2020.100796

Cited by 5 publications

(4 citation statements)

References 27 publications

(28 reference statements)

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“… Rodent Bartonella fuyuanensis Validly published under the ICNP No Yes [ 62 ] 2015 Lophuromys sp . Rodent Bartonella gabonensis Not validly published No No [ 179 ] 2020 Gerbillus spp. Rodent Bartonella gerbillinarum Not validly published Yes Yes [ 180 ] 2018 Clethrionomys glareolus Rodent Bartonella grahamii Validly published under the ICNP No Yes [ 176 ] 1995 Rodents Rodent Bartonella heixiaziensis Validly published under the ICNP No Yes [ 62 ] 2015 Jaculus orientalis Rodent Bartonella jaculi Validly published under the ICNP No Yes [ 51 ] 2013 Apodemus argenteus Rodent Bartonella japonica ...…”

Section: Clinical Cases Of Bartonellosis In Humans In the Context Of ...mentioning

confidence: 99%

Emerging rodent-associated Bartonella: a threat for human health?

Krügel,

Król,

Kempf

et al. 2022

Parasites Vectors

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Background Species of the genus Bartonella are facultative intracellular alphaproteobacteria with zoonotic potential. Bartonella infections in humans range from mild with unspecific symptoms to life threatening, and can be transmitted via arthropod vectors or through direct contact with infected hosts, although the latter mode of transmission is rare. Among the small mammals that harbour Bartonella spp., rodents are the most speciose group and harbour the highest diversity of these parasites. Human–rodent interactions are not unlikely as many rodent species live in proximity to humans. However, a surprisingly low number of clinical cases of bartonellosis related to rodent-associated Bartonella spp. have thus far been recorded in humans. Methods The main purpose of this review is to determine explanatory factors for this unexpected finding, by taking a closer look at published clinical cases of bartonellosis connected with rodent-associated Bartonella species, some of which have been newly described in recent years. Thus, another focus of this review are these recently proposed species. Conclusions Worldwide, only 24 cases of bartonellosis caused by rodent-associated bartonellae have been reported in humans. Possible reasons for this low number of cases in comparison to the high prevalences of Bartonella in small mammal species are (i) a lack of awareness amongst physicians of Bartonella infections in humans in general, and especially those caused by rodent-associated bartonellae; and (ii) a frequent lack of the sophisticated equipment required for the confirmation of Bartonella infections in laboratories that undertake routine diagnostic testing. As regards recently described Bartonella spp., there are presently 14 rodent-associated Candidatus taxa. In contrast to species which have been taxonomically classified, there is no official process for the review of proposed Candidatus species and their names before they are published. This had led to the use of malformed names that are not based on the International Code of Nomenclature of Prokaryotes. Researchers are thus encouraged to propose Candidatus names to the International Committee on Systematics of Prokaryotes for approval before publishing them, and only to propose new species of Bartonella when the relevant datasets allow them to be clearly differentiated from known species and subspecies. Graphical Abstract

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Section: Clinical Cases Of Bartonellosis In Humans In the Context Of ...mentioning

confidence: 99%

Emerging rodent-associated Bartonella: a threat for human health?

Krügel,

Król,

Kempf

et al. 2022

Parasites Vectors

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“…gabonensis and B . raoultii [ 18 , 22 , 23 , 26 , 27 , 28 , 29 ]. The risks that they pose to human and animal health remain unknown.…”

Section: Discussionmentioning

confidence: 99%

Detection of Potential Zoonotic Bartonella Species in African Giant Rats (Cricetomys gambianus) and Fleas from an Urban Area in Senegal

et al. 2022

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Bartonellae are bacteria associated with mammals and their ectoparasites. Rodents often host different species of Bartonella. The aim of this study was to investigate the presence of Bartonella spp. in African giant pouched rats (Cricetomys gambianus) and their ectoparasites in Dakar, Senegal. In 2012, 20 rats were caught, and their fleas were identified. DNA was extracted from 170 selected fleas and qPCR was carried out to detect Bartonella spp. Subsequently, a Bartonella culture was performed from the rat blood samples and the isolated strains (16S rRNA, rpoB, ftsZ and ITS3) were genotyped. A total of 1117 fleas were collected from 19 rats and identified as Xenopsylla cheopis, the tropical rat flea. Bartonella DNA was detected in 148 of 170 selected fleas (87.1%). In addition, Bartonella strains were isolated from the blood of 17 rats (85%). According to Bartonella gene-sequence-based criteria for species definition, the isolated strains were identified as B. massiliensis (four strains) and two potential new species related to the zoonotic B. elizabethae. In this paper, these potentially new species are provisionally called Candidatus Bartonella militaris (11 strains) and Candidatus Bartonella affinis (two strains) until their description has been completed. Cricetomys gambianus and its fleas could constitute a public health risk in Dakar due to the high prevalence of Bartonella infection reported.

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“…The genus grew from just one member with the discovery of B. bacilliformis in 1909, to five members in 1993, when the Bartonella and Rochalimaea genera were united( R L Regnery, Anderson, et al 1992 ; Noguchi and Battistini 1926 ; Brenner et al 1993 ; Daly et al 1993 ; Russell L Regnery, Olson, et al 1992 ). Since then, the number of known Bartonella species has grown to more than fifty-five current and Candidatus members( Breitschwerdt 2017 ; K. E. Mullins et al 2015 ; Mangombi et al 2020 ; Gutiérrez et al 2020 ; Medkour et al 2019 ). Bartonella species have been isolated from a wide variety of invertebrates, including fleas, ticks, body lice, sheep keds, and even spiders, and hosts including humans, cats, dogs, rats, cattle, foxes, and bats( Breitschwerdt 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Bartonella Species in Cambodia, Ghana, Laos, and Peru: Results from Vector and Serosurveys

Mullins

Canal

Ouch

et al. 2023

Vector-Borne and Zoonotic Diseases

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Bartonella species are fastidious Gram negative vector-borne bacteria with a wide range of mammalian reservoirs. While it is understood that some species Bartonella are human pathogens, the extent of human exposure to Bartonella species (both pathogenic and non-pathogenic) has yet to be fully understood. To this end, residual sera from participants enrolled in undifferentiated fever studies in Cambodia, Ghana, Laos, and Peru were screened for the presence of IgG antibodies against B. quintana and B. henselae, using the FOCUS diagnostics Dual Spot-Bartonella IgG Immunofluorescence assay. Forty-eight patients with suspected or confirmed B. bacilliformis exposure or infection in Peru, were screened to assess cross-reactivity of the FOCUS assay for IgG against other Bartonella species. Ten of 13 patients with confirmed B. bacilliformis infection were Bartonella-specific IgG positive and overall, 36/48 of the samples were positive. Additionally, 79/206, 44/200, 101/180, and 57/100 of samples from Peru, Laos, Cambodia, and Ghana, respectively were Bartonella-specific IgG positive. Further, ectoparasites pools from Cambodia, Laos, and Peru were tested using quantitative real-time PCR (qPCR) for the presence of Bartonella DNA. Of the sand-fly pools collected in Peru, 0/196 were qPCR positive; 15/140 flea pools collected in Cambodia were qPCR positive; while 0/105 ticks, 0/22 fleas, and 0/3 louse pools collected in Laos tested positive for Bartonella DNA. Evidence of Bartonella in fleas from Cambodia supports the possibility that humans are exposed to Bartonella through this traditional vector. However, Bartonella species were not found in fleas, ticks, or lice from Laos, or sandflies from Peru. This could account for the lower positive serology among the population in Laos and the strictly localized nature of B. bacillformis infections in Peru. Human exposure to Bartonella species and Bartonella as a human pathogen warrants further investigation.

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Bartonella gabonensis sp. nov., a new bartonella species from savannah rodent Lophuromys sp. in Franceville, Gabon

Cited by 5 publications

References 27 publications

Emerging rodent-associated Bartonella: a threat for human health?

Emerging rodent-associated Bartonella: a threat for human health?

Detection of Potential Zoonotic Bartonella Species in African Giant Rats (Cricetomys gambianus) and Fleas from an Urban Area in Senegal

Bartonella Species in Cambodia, Ghana, Laos, and Peru: Results from Vector and Serosurveys

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