Barriers to the management of Diabetes Mellitus – is there a future role for Laser Doppler Flowmetry?

Abstract

Diabetes Mellitus (DM) is a chronic disease that carries a significant disease burden in Australia and worldwide. The aim of this paper is to identify current barriers in the management of diabetes, ascertain whether there is a benefit from early detection and determine whether LDF has the potential to reduce the disease burden of DM by reviewing the literature relating to its current uses and development. In this literature review search terms included; laser Doppler flowmetry, diabetes mellitus, barriers to management, uses, future, applications, vasomotion, subcutaneous, cost. Databases used included Google Scholar, Scopus, Science Direct and Medline. Publications from the Australian government and textbooks were also utilised. Articles reviewed had access to the full text and were in English.

The current state of diabetes mellitus in India

“…Early screening and detection of pre-diabetes (especially in pregnant women, 26 children and adults with BMI ≥25) may yield positive health outcomes in society. 27 Continuing education programmes for general practitioners may provide the "clinical inertia" required to initiate programme adherence, and may be a major step in achieving target glycaemic levels and the prevention of disease complications. Aggressive clinical measures in terms of early insulin initiation combined with optimal doses of oral hypoglycaemic agents and appropriate lifestyle modification could also have long-term positive effects in disease management.…”

Prospects of Laser Doppler flowmetry application in assessment of skin microcirculation in diabetes

“…Так, X. Tigno и соавт., 2011, в исследовании на макаках-резус с разными стади-ями развития СД продемонстрировали, что хаотичность вазомоций снижается при прогрессировании СД [41]. Это можно объяснить нарушением гомеостатической функции микроциркуляторной сети и утратой возмож-ности постоянного быстрого реагирования на изменения окружающей среды [42]. На экспериментальной модели инсулинорезистентности (крысы Wistar) J. Newman и соавт., 1990, показали, что инсулин напрямую взаи-модействует с рецепторами гладкомышечных клеток (в т.ч.…”

“…К недостаткам анализа амплитудно-частотных ха-рактеристик микроциркуляторных ритмов можно от-нести высокую чувствительность к изменениям условий эксперимента (температура в помещении, движения пациента), высокую длительность регистрации перфу-зии (30-40 минут), а также необходимость использова-ния специализированного программного обеспечения для пострегистрационной обработки данных, что требует от оператора достаточно высокой квалификации [42].…”

Control of Post Prandial Blood Sugar Among the Treatment Patterns for Type 2 Diabetic Mellitus: A Retrospective Study

“…Since selfmonitoring of blood glucose increases a significant financial and personal burden for patients. 3 It is predicted that by 2030 diabetes mellitus may afflict up to 79.4 million individuals in India. 1 Particularly in Tamil Nadu, 4.8 million population are affected with diabetes mellitus as of now.…”