Barriers, facilitators, perceptions and impact of interventions in implementing antimicrobial stewardship programs in hospitals of low-middle and middle countries: a scoping review

Abstract

Background Antimicrobial stewardship programs (ASPs) are pivotal components of the World Health Organization's Global Action Plan to combat antimicrobial resistance (AMR). ASPs advocate rational antibiotic usage to enhance patient-centered outcomes. However, existing evidence on ASPs and their determinants is largely limited to well-equipped hospitals in high-income nations. Objective This scoping review aimed to examine the current state of hospital-based ASPs in low- and middle-income countries (LMICs), shedding light on barriers, facilitators, prescribers’ perceptions and practices, and the impact of ASP interventions. Design Scoping review on ASP. Methods Adhering to PRISMA guidelines, we conducted electronic database searches on PubMed, Scopus, and Google Scholar, covering ASP articles published between January 2015 and October 2023. Our review focused on four key domains: barriers to ASP implementation, facilitators for establishing ASP, ASP perceptions and practices of prescribers, and the impact of ASP interventions. Three reviewers separately retrieved relevant data from the included citations using EndNote 21.0. Results Among the 7016 articles searched, 84 met the inclusion criteria, representing 34 LMICs. Notably, 58% (49/84) of these studies were published after 2020. Barriers to ASP implementation, including human-resources shortage, lack of microbiology laboratory support, absence of leadership, and limited governmental support, were reported by 26% (22/84) of the studies. Facilitators for hospital ASP implementation identified in five publications included the availability of antibiotic guidelines, ASP protocol, dedicated multidisciplinary ASP committee, and prompt laboratory support. The majority of the research (63%, 53/84) explored the impacts of ASP intervention on clinical, microbiological, and economic aspects. Key outcomes included increased antibiotic prescription appropriateness, reduced antimicrobial consumption, shorter hospital stays, decreased mortality rate, and reduced antibiotic therapy cost. Conclusions The published data underscores the imperative need for widespread antimicrobial stewardship in LMIC hospital settings. Substantial ASP success can be achieved through increasing human resources, context-specific interventions, the development of accessible antibiotic usage guidelines, and heightened awareness via training and education.

Assessment of challenges and opportunities in antibiotic stewardship program implementation in Northwest Ethiopia

“…Implementation of agreed-upon ASPs, which do have beneficial clinical and economic impacts, following identified gaps is a key to tackle AMR [ 64 , 65 ]. Identifying perceptions, enablers, and barriers to ASP implementation is a critical step for the successful implementation of ASPs in hospitals [ 44 , [66] , [67] , [68] , [69] , [70] ]. Determining the knowledge, perceptions and attitudes of hospital-based clinicians toward antimicrobial prescription, AMR, and ASP, including the types of activities implemented in hospital-based ASPs, the methods used to measure the impact of ASP, and factors influencing the antimicrobial prescribing behavior of physicians, are necessary components to initiating ASP [ 71 ].…”