Background and Purpose-One of the major consequences after stroke is the deterioration in health-related quality of life (HRQOL). Three previous systematic reviews indicated that exercise has limited to no effect in improving HRQOL in stroke survivors. The objective of this meta-analysis was to update the evidence on exercise and HRQOL in stroke survivors with additional new information on randomized controlled trials that have been published since these 3 previous reviews. Methods-MEDLINE, Cumulated Index to Nursing and Allied Health Literature, EMBASE, and SportsDiscus databases were searched for randomized controlled trials reporting the effects of exercise on HRQOL in stroke survivors from 1950 to March 2010. The methodological quality of each study was appraised using the Physiotherapy Evidence Database scale. Standardized mean difference was used to compute effect size and subgroup analysis was conducted to test the consistency of results across the subgroups with different characteristics. Results-A total of 1101 citations was identified and 9 studies met all criteria for a total sample of 426 stroke survivors.Eight studies were rated as good quality (ie, Physiotherapy Evidence Database scale Ն5). This meta-analysis provided evidence that exercise can have a small to medium effect on HRQOL outcomes (standardized mean difference, 0.32, PϽ0.01) at postintervention but not at follow-up after exercise was terminated (standardized mean difference, 0.17, Pϭ0.12). No adverse events related to exercise were reported. Conclusions-The results provide moderate support for the use of exercise to improve HRQOL in stroke survivors. However, the challenge for researchers is identifying effective strategies for sustaining these effects postintervention. (Stroke. 2011;42:832-837.)Key Words: exercise Ⅲ meta-analysis Ⅲ quality of life Ⅲ stroke Ⅲ systematic review S troke survivors report a poorer health-related quality of life (HRQOL) compared with the general population. 1-3 Although HRQOL is a multidimensional concept, it is usually measured by physical or mental attributes associated with overall health status. 4,5 For stroke survivors, the physical attributes of HRQOL include the interference they perceive in performing physical activities such as the ability to walk 1 block or by responses to pain levels associated with performing activities (eg, work outside the home and housework), 4,5 and mental attributes are often measured by the perception of subjective feelings of interference in participating in social activities. 4,5 Exercise may offset some of the decline in HRQOL in stroke survivors by (1) reducing secondary conditions such depression and pain; and/or (2) improving overall physical fitness, which leads to higher levels of physical function (eg, greater self-efficacy in performing activities of daily living). 6 The dozen or so systematic reviews that have been published on the effects of exercise in stroke survivors [7][8][9][10][11][12][13][14][15][16][17][18][19] have focused almost entirely on phys...