Barriers and activities to implementing or expanding influenza vaccination programs in low- and middle-income countries: A global survey

Kraigsley, Alison M.; Moore, Kristine A.; Bolster, Amanda; Peters, Maya; Richardson, Donna; Arpey, Meredith; Sonnenberger, Michelle; McCarron, Margaret; Lambach, Philipp; Maltezou, Helena C.; Bresee, Joseph S.

doi:10.1016/j.vaccine.2021.04.043

Cited by 18 publications

(10 citation statements)

References 38 publications

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“…Several barriers challenge the successful implementation of influenza vaccination programs, particularly in low-and middle-income countries [27,28]. These barriers include a lack of clear data regarding the burden of influenza; competing health priorities, compromising financial support for the vaccination program; and vaccine hesitancy, forming a major obstacle to influenza vaccine uptake [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

The Role of Psychological Factors and Vaccine Conspiracy Beliefs in Influenza Vaccine Hesitancy and Uptake among Jordanian Healthcare Workers during the COVID-19 Pandemic

et al. 2022

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Vaccination to prevent influenza virus infection and to lessen its severity is recommended among healthcare workers (HCWs). Health professionals have a higher risk of exposure to viruses and could transmit the influenza virus to vulnerable patients who are prone to severe disease and mortality. The aim of the current study was to evaluate the levels of influenza vaccine acceptance and uptake as well as its determinants, among Jordanian HCWs over the last influenza season of 2021/2022. This study was based on a self-administered electronic survey that was distributed in March 2022. Psychological determinants of influenza vaccine acceptance and vaccine conspiracy beliefs were assessed using the previously validated 5C scale questionnaire (confidence, complacency, constraints, calculation and collective responsibility) and the vaccine conspiracy beliefs scale. The study sample comprised a total of 1218 HCWs: nurses (n = 412, 33.8%), physicians (n = 367, 30.1%), medical technicians (n = 182, 14.9%), pharmacists (n = 161, 13.2%) and dentists (n = 87, 7.1%), among others. About two-thirds of the study sample expressed willingness to receive influenza vaccination if provided free of charge (n = 807, 66.3%), whereas less than one-third were willing to pay for the vaccine (n = 388, 31.9%). The self-reported uptake of the influenza vaccine in the last influenza season was 62.8%. The following factors were significantly associated with higher acceptance of influenza vaccination if provided freely, as opposed to vaccine hesitancy/rejection: male sex; physicians and dentists among HCW categories; higher confidence and collective responsibility; and lower complacency, constraints and calculation. Higher influenza vaccine uptake was significantly correlated with nurses and physicians among HCW categories, older age, a higher monthly income, higher confidence and collective responsibility, lower complacency and constraints and lower embrace of general vaccine conspiracy beliefs. The results of the current study can provide helpful clues to improve influenza vaccine coverage among HCWs in Jordan. Consequently, this can help to protect vulnerable patient groups and reserve valuable resources in healthcare settings. Psychological determinants appeared to be the most significant factors for vaccine acceptance and uptake, whereas the embrace of general vaccine conspiracy beliefs was associated with lower rates of influenza vaccine uptake, which should be considered in educational and interventional measures aiming to promote influenza vaccination.

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Section: Introductionmentioning

confidence: 99%

The Role of Psychological Factors and Vaccine Conspiracy Beliefs in Influenza Vaccine Hesitancy and Uptake among Jordanian Healthcare Workers during the COVID-19 Pandemic

et al. 2022

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“…Several studies have shown that people in Africa are willing to receive vaccinations, provided the vaccines are available at convenience, affordable and accessible (Anjorin, et al, 2021). Vaccine uptake is also governed by the design of the user journey (Kraigsley, et al, 2021;Wolf, et al, 2020).…”

Section: Emerging Lessons Learned On What Has Worked In Africa and Ot...mentioning

confidence: 99%

“…Hence, people will opt for not getting vaccinated (Ankomah, et al, 2022). Experts argue that there is certainly a lot out there with data not being used or shared because people do not know about them, have a different expectation on how to collect for, analyse, and use the data sets, or do not have the means to access data (Kraigsley, et al, 2021;and Partnership for Evidence-Based Response to COVID-19, 2021). To make a difference in the COVID-19 vaccine uptake across countries, it is crucial to have a shared repository of all data sets rather than have standalone repositories per funding agency, or driven by donor motives, or organizational philosophy.…”

Section: Lesson Three: Knowledge Sharing Is Pivotal But Managing What...mentioning

confidence: 99%

Increasing COVID-19 Vaccine Uptake in Africa

El-Kour¹

2022

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This evidence brief comprises of two key sections: the first section focuses on emerging lessons of what has worked to increase COVID-19 vaccine uptake in Africa and other low- and middle-income country (LMIC) contexts. This rapid review draws from evidence released since 2020 from research papers to commentaries, statements, positions papers and grey literature, blogs, newspapers, and other journalism, in addition to key informant interviews with key experts in the field.

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“…Other political, economic, and social factors are also involved. These are illustrated in Hayman et al, Kraigsley et al, and Phillips et al [113][114][115]. Lowering the overall manufacturing costs is an essential requitement to help LMICs to become more independent.…”

Section: Some Economic Considerationsmentioning

confidence: 99%

Pichia pastoris (Komagataella phaffii) as a Cost-Effective Tool for Vaccine Production for Low- and Middle-Income Countries (LMICs)

Magalhaes

Keshavarz-Moore

2021

Bioengineering

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Vaccination is of paramount importance to global health. With the advent of the more recent pandemics, the urgency to expand the range has become even more evident. However, the potential limited availability and affordability of vaccines to resource low- and middle-income countries has created a need for solutions that will ensure cost-effective vaccine production methods for these countries. Pichia pastoris (P. pastoris) (also known as Komagataella phaffii) is one of the most promising candidates for expression of heterologous proteins in vaccines development. It combines the speed and ease of highly efficient prokaryotic platforms with some key capabilities of mammalian systems, potentially reducing manufacturing costs. This review will examine the latest developments in P. pastoris from cell engineering and design to industrial production systems with focus on vaccine development and with reference to specific key case studies.

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Barriers and activities to implementing or expanding influenza vaccination programs in low- and middle-income countries: A global survey

Cited by 18 publications

References 38 publications

The Role of Psychological Factors and Vaccine Conspiracy Beliefs in Influenza Vaccine Hesitancy and Uptake among Jordanian Healthcare Workers during the COVID-19 Pandemic

The Role of Psychological Factors and Vaccine Conspiracy Beliefs in Influenza Vaccine Hesitancy and Uptake among Jordanian Healthcare Workers during the COVID-19 Pandemic

Increasing COVID-19 Vaccine Uptake in Africa

Pichia pastoris (Komagataella phaffii) as a Cost-Effective Tool for Vaccine Production for Low- and Middle-Income Countries (LMICs)

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