Barrier and Antiviral Effect of a New Cream Formulation

Spencer, Brian; Brandt, Curtis R.

doi:10.1086/647577

Cited by 1 publication

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antiadhesive sur faces, such as hydrophobic coatings, have been proposed as a method of preventing periprosthetic infections. While these coatings resist the adherence of prokaryotic cells, [22][23][24][25][26][27] they also result in poor protein and eukaryotic cell adhesion which ultimately leads to a lack of tissue integration. [22] Although the direct incorporation of antiseptics and antibiotics into the polymer's structure has been demonstrated, controlling their elution kinetics [24] has proven to be particularly challenging and especially inoperative against antibioticresistant bacterial strains.…”

Section: N 4 Ceramics In Terms Of Osteogenic Behavior (Vs Both Osteosmentioning

confidence: 99%

Incorporating Si₃N₄ into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants

Pezzotti

Marin

Adachi

et al. 2018

Macromolecular Bioscience

View full text Add to dashboard Cite

Polyetheretherketone (PEEK) is a popular polymeric biomaterial which is primarily used as an intervertebral spacer in spinal fusion surgery; but it is developed for trauma, prosthodontics, maxillofacial, and cranial implants. It has the purported advantages of an elastic modulus which is similar to native bone and it can be easily formed into custom 3D shapes. Nevertheless, PEEK's disadvantages include its poor antibacterial resistance, lack of bioactivity, and radiographic transparency. This study presents a simple approach to correcting these three shortcomings while preserving the base polymer's biocompatibility, chemical stability, and elastic modulus. The proposed strategy consists of preparing a PEEK composite by dispersing a minor fraction (i.e., 15 vol%) of a silicon nitride (Si N ) powder within its matrix. In vitro tests of PEEK composites with three Si N variants-β-Si N , α-Si N , and β-SiYAlON-demonstrate significant improvements in the polymer's osteoconductive versus SaOS-2 cells and bacteriostatic properties versus gram-positive Staphylococcus epidermidis bacteria. These properties are clearly a consequence of adding the bioceramic dispersoids, according to chemistry similar to that previously demonstrated for bulk Si N ceramics in terms of osteogenic behavior (vs both osteosarcoma and mesenchymal progenitor cells) and antibacterial properties (vs both gram-positive and gram-negative bacteria).

show abstract

Section: N 4 Ceramics In Terms Of Osteogenic Behavior (Vs Both Osteosmentioning

confidence: 99%

Incorporating Si₃N₄ into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants

Pezzotti

Marin

Adachi

et al. 2018

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

Barrier and Antiviral Effect of a New Cream Formulation

Cited by 1 publication

References 5 publications

Incorporating Si₃N₄ into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants

Incorporating Si₃N₄ into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants

Contact Info

Product

Resources

About

Barrier and Antiviral Effect of a New Cream Formulation

Cited by 1 publication

References 5 publications

Incorporating Si3N4 into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants

Incorporating Si3N4 into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants

Contact Info

Product

Resources

About

Incorporating Si₃N₄ into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants

Incorporating Si₃N₄ into PEEK to Produce Antibacterial, Osteocondutive, and Radiolucent Spinal Implants