Barrett's esophagus: lack of association with adjuvant chemotherapy for localized breast carcinoma

Herrera, Jorge; Uzel, Connie; Martino, Roy L.; Cooke, Carole A; DiPalma, Jack A.

doi:10.1016/s0016-5107(92)70514-8

Cited by 8 publications

(12 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic gastroesophageal reflux disease is the most significant risk factor for developing specialized intestinal metaplasia, however its effect upon the esophageal epithelium and its contribution to the metaplasia/carcinoma sequence of continual or intermittent reflux of acid, bile or other gastroduodenal contents remains to be elucidated. Additional risk factors of less significance include white race, male gender, obesity, and membership of affluent Western societies, whereas smoking, alcohol consumption, Helicobacter pylori infection, and previous chemotherapy are considered to be of minimal significance 10 –12 …”

Section: Environmental and Host Factorsmentioning

confidence: 99%

Barrett’s esophagus: an overview of the molecular biology *

Aldulaimi

Jankowski

1999

Diseases of the Esophagus

View full text Add to dashboard Cite

The significance of specialized intestinal metaplasia in the esophagus is its associated risk with esophageal adenocarcinoma. This tumor has increased in incidence by over 70% in 20 years. Specialized intestinal metaplasia is the most important risk factor for adenocarcinoma of the esophagus and has been reported in 9-32% of unselected patients in general endoscopy units. The annual risk of esophageal adenocarcinoma for patients with specialized intestinal metaplasia is thought to be approximately 1%, at least 30 times that of the general population. Those with long segments of specialized intestinal metaplasia are thought to be at the greatest risk. Both environmental and molecular changes have been identified in the transition from squamous epithelium through specialized intestinal metaplasia to esophageal adenocarcinoma. The most important molecular changes include impaired regulation of the cell cycle, altered function of known oncogenes and tumor-suppressor genes, changes in cell adhesion molecules, and aneuploidy. This has given rise to a metaplasia/dysplasia/carcinoma model for the evolution of esophageal carcinoma.

show abstract

Section: Environmental and Host Factorsmentioning

confidence: 99%

Barrett’s esophagus: an overview of the molecular biology *

Aldulaimi

Jankowski

1999

Diseases of the Esophagus

View full text Add to dashboard Cite

show abstract

“…Three of 16 patients had intestinal metaplasia, while the others had gastric or fundic metaplasia. Subsequent studies by Herrera and Peters, however, did not verify this association between BE and chemotherapy [24,25].…”

Section: Discussionmentioning

confidence: 92%

“…However, controversy exists regarding whether radiation increases the risk for BE and/or adenocarcinoma [4,[8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Chemotherapy has also been thought by some, but not by others, to lead to BE [22][23][24][25]. We, therefore, conducted this study to test the hypothesis that exposure to radiation therapy and/or chemotherapy increases the risk of BE and/or MLE.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Both Radiation and Chemotherapy Increases the Risk of Barrett’s and Multilayered Epithelium

2008

View full text Add to dashboard Cite

The relationship between radiation and/or chemotherapy and the development of Barrett's and/or multilayered epithelium has not been investigated before. We ascertained a group of patients exposed to radiation and/or chemotherapy and an unexposed group to compare the prevalence rates of Barrett's epithelium and multilayered epithelium at the time of endoscopy in these two groups. Barrett's epithelium was found in ten of the 19 (53%) exposed patients, compared to eight of 38 (21%) unexposed subjects (P = 0.02). Six of 19 (32%) exposed patients had multilayered epithelium, compared to four of 38 (11%) unexposed subjects (P = 0.06). Twelve of the 19 exposed patients (63%) had either Barrett's or multilayered epithelium, in contrast to ten of 38 (26%) unexposed subjects (P = 0.01). Those with exposure to both chemotherapy and radiation had a significant increase in the risk for Barrett's and/or multilayered epithelium (P = 0.003). This study suggests a relationship between exposure to a combination of radiation and chemotherapy and the development of Barrett's and/or multilayered epithelium.

show abstract

“…Risk factors of less significance could include male gender, obesity, and an irrational lifestyle, whereas smoking, alcohol consumption, Helicobacter pylori infection, and previous chemotherapy are considered to be of minimal significance (2)(3)(4). However, benign esophageal stenoses occur infrequently, particularly in middle-aged people who have healthy lifestyles.…”

Section: Treatment Of Unusual Esophageal Stenosis Caused By Gastroesomentioning

confidence: 99%

Treatment of unusual esophageal stenosis caused by gastroesophageal reflux disease

Ji²,

Han³

et al. 2016

Turk J Gastroenterol

View full text Add to dashboard Cite

Barrett's esophagus: lack of association with adjuvant chemotherapy for localized breast carcinoma

Cited by 8 publications

References 11 publications

Barrett’s esophagus: an overview of the molecular biology *

Barrett’s esophagus: an overview of the molecular biology *

Exposure to Both Radiation and Chemotherapy Increases the Risk of Barrett’s and Multilayered Epithelium

Treatment of unusual esophageal stenosis caused by gastroesophageal reflux disease

Contact Info

Product

Resources

About