Barrett's esophagus is associated with a distinct oral microbiome

Snider, Erik J.; Compres, Griselda; Freedberg, Daniel E.; Giddins, Marla J.; Khiabanian, Hossein; Lightdale, Charles J.; Nobel, Yael R.; Toussaint, Nora C.; Uhlemann, Anne Catrin; Abrams, Julian A.

doi:10.1038/s41424-018-0005-8

Cited by 53 publications

(68 citation statements)

References 46 publications

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“…In addition, a study showed that decreased abundance of Proteobacteria and increased abundance of Firmicutes was associated with BE, which was consistent with our findings (Snider et al, 2018). We also observed Veillonella, a core microbiome, was significantly enriched in EC patients.…”

Section: Discussionsupporting

confidence: 92%

Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer

Zhao

Yang

Yan

et al. 2020

Front. Cell. Infect. Microbiol.

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Emerging evidence supports that oral microbiota are associated with health and diseases of the esophagus. How oral microbiota change in Chinese patients with esophageal cancer (EC) is unknown, neither is their biomarker role. For an objective to understand alterations of oral microbiota in Chinese EC patients, we conducted a case-control study including saliva samples from 39 EC patients and 51 healthy volunteers. 16S rDNA genes of V3-V4 variable regions were sequenced to identify taxon. Relationship between oral flora and disease was analyzed according to alpha diversity and beta diversity. Resultantly, the Shannon index (p = 0.2) and the Simpson diversity index (p = 0.071) were not significant between the two groups. Yet we still found several species different in abundance between the two groups. For the EC group, the most significantly increased taxa were Firmicutes, Negativicutes, Selenomonadales, Prevotellaceae, Prevotella, and Veillonellaceae, while the most significantly decreased taxa were Proteobacteria, Betaproteobacteria, Neisseriales, Neisseriaceae, and Neisseria. In conclusion, there are significant alterations in abundance of some oral microbiomes between the EC patients and the healthy controls in the studied Chinese participants, which may be meaningful for predicting the development of EC, and the potential roles of these species in EC development deserve further studies.

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Section: Discussionsupporting

confidence: 92%

Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer

Zhao

Yang

Yan

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Thus, and AUC of 0.9 would indicate that the probability of discriminating a case vs. control is 90%. In Table 1, we show three examples of combined taxons to distinguish controls vs. cancer samples: a three taxon model of Lautropia, Streptococcus and an unspecified genus of the order Bacteroidales, with AUC =0.94, has been associated with esophageal cancer (66), a two taxon model, Streptococcus mitis and Neisseria elongata with an AUC of 0.90, associated with pancreatic cancer (71) and a bacterial cluster associated with gastric cancer with AUC of 0.76 (96). Finally, another approach to the use of biomarkers in differentiating case vs. control samples is using changes in biodiversity indicators as a proxy of changes in the microbiome that could be linked to the status of the sample, independently of what organisms are present or absent.…”

Section: Oral Microorganisms and Cancers Outside The Oral Cavitymentioning

confidence: 99%

The Oral Microbiome and Cancer

2020

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There is mounting evidence that members of the human microbiome are highly associated with a wide variety of cancer types. Among oral cancers, oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied, and it is the most common malignancy of the head and neck worldwide. However, there is a void regarding the role that the oral microbiome may play in OSCC. Previous studies have not consistently found a characteristic oral microbiome composition associated with OSCC. Although a direct causality has not been proven, individual members of the oral microbiome are capable of promoting various tumorigenic functions related to cancer development. Two prominent oral pathogens, Porphyromonas gingivalis, and Fusobacterium nucleatum can promote tumor progression in mice. P. gingivalis infection has been associated with oro-digestive cancer, increased oral cancer invasion, and proliferation of oral cancer stem cells. The microbiome can influence the evolution of the disease by directly interacting with the human body and significantly altering the response and toxicity to various forms of cancer therapy. Recent studies have shown an association of certain phylogenetic groups with the immunotherapy treatment outcomes of certain tumors. On the other side of the coin, recently it has been a resurgence in interest on the potential use of bacteria to cure cancer. These kinds of treatments were used in the late nineteenth and early twentieth centuries as the first line of defense against cancer in some hospitals but later displaced by other types of treatments such as radiotherapy. Currently, organisms such as Salmonella typhimurium and Clostridium spp. have been used for targeted strategies as potential vectors to treat cancer. In this review, we briefly summarize our current knowledge of the role of the oral microbiome, focusing on its bacterial fraction, in cancer in general and in OSCC more precisely, and a brief description of the potential use of bacteria to target tumors.

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“…Oral and esophageal microbial compositions are closely related, possibly due to movement of oral microbes to more distal gastrointestinal sites; 32 as such, it is possible that the associations between dietary fiber and esophageal microbiota may be mediated by effects of fiber or other related factors on the oral microbiome. Similarly, perhaps through association with obesity, fiber intake could be associated with frequency or severity of acid reflux and reflux-associated disease, another factor with known associations with altered upper gastrointestinal microbiome composition 3 , 17 , 33 . On the other hand, dietary fiber could impact the esophageal microbiome via its effects on host metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…Patient data and samples used for the current study had been previously collected for a case-control study of the esophageal microbiome in adult patients with and without BE, described elsewhere in detail 17 . Briefly, patients ≥18 years old who were scheduled to undergo upper endoscopy for clinical indications were included.…”

Section: Methodsmentioning

confidence: 99%

Increasing Dietary Fiber Intake Is Associated with a Distinct Esophageal Microbiome

Nobel

Snider

Compres

et al. 2018

Clinical and Translational Gastroenterology

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IntroductionThere is increasing evidence that the microbiome contributes to esophageal disease. Diet, especially fiber and fat intake, is a known potent modifier of the colonic microbiome, but its impact on the esophageal microbiome is not well described. We hypothesized that dietary fiber and fat intake would be associated with a distinct esophageal microbiome.MethodsWe collected esophageal samples from 47 ambulatory patients scheduled to undergo endoscopy who completed a validated food frequency questionnaire quantifying dietary fiber and fat intake. Using 16S high-throughput sequencing, we determined composition of the esophageal microbiome and predicted functional capacity of microbiota based on fiber and fat intake.ResultsAmong all samples, the most abundant phyla were Firmicutes (54.0%), Proteobacteria (19.0%), Bacteroidetes (17.0%), Actinobacteria (5.2%), and Fusobacteria (4.3%). Increasing fiber intake was significantly associated with increasing relative abundance of Firmicutes (p = 0.04) and decreasing relative abundance of Gram-negative bacteria overall (p = 0.03). Low fiber intake was associated with increased relative abundance of several Gram-negative bacteria, including Prevotella, Neisseria, and Eikenella. Several predicted metabolic pathways differed between highest and lowest quartile of fiber intake. Fat intake was associated with altered relative abundance of few taxa, with no alterations at the phylum level and no changes in microbiome functional composition.ConclusionsDietary fiber, but not fat, intake was associated with a distinct esophageal microbiome. Diet should be considered an important modifier of the esophageal microbiome in future studies. Studies are also needed to elucidate how the effects of dietary fiber on the esophageal microbiome may contribute to esophageal disease.

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Barrett's esophagus is associated with a distinct oral microbiome

Cited by 53 publications

References 46 publications

Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer

Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer

The Oral Microbiome and Cancer

Increasing Dietary Fiber Intake Is Associated with a Distinct Esophageal Microbiome

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