Abstract:The definition of Barrett's esophagus is conceptually simple. It is the replacement of the normal squamous mucosa by specialized intestinal metaplasia within the esophagus. Barrett's esophagus would only be a clinical curiosity if not for its predisposition toward neoplastic change. In spite of all the knowledge and data gathered thus far on Barrett's, much remains unknown. Why do some patients develop Barrett's while others do not? Why do some with Barrett's advance to adenocarcinoma? Once Barrett's develops,… Show more
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