Abstract:Facioscapulohumeral muscular dystrophy (FSHD), the third most common muscular dystrophy, is caused by a genetic mutation that alters DUX4 gene expression. Although cardiac muscle is known to be spared in people with FSHD, they can develop significant morbidities and physical disabilities because of their reduced mobility. Autonomic dysregulation via heart rate variability has been demonstrated in people with FSHD. It is unknown, however, if baroreflex function, an important regulator of blood pressure, is impa… Show more
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