Baroreflex Sensitivity in Children and Adolescents: Physiology, Hypertension, Obesity, Diabetes Mellitus

Honzíková, Nataša; Závodná, Eva

doi:10.33549/physiolres.933271

Cited by 18 publications

(18 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, both the decrease in BRS and the increase in LF/HF ratio from supine to upright were significantly greater in pediatric patients with OHT than those in controls. The reduction of BRS is associated with the sympathetic activation (17,26,27), and the increased LF/HF ratio indicates an obvious sympathetic predominance. Therefore, the significant drop of BRS and the remarkably increased LF/HF ratio at standing in the OHT patients demonstrated sympathetic overactivity in adolescents with OHT when upright.…”

Section: Discussionmentioning

confidence: 99%

“…Baroreflex is essential in the instant regulation of BP (24,25), and LF/HF ratio reflects the predominant component among sympathetic and vagal tone (18). Normally, BRS and RRI variability decrease but LF/HF ratio increases after standing (17,18,26). However, both the decrease in BRS and the increase in LF/HF ratio from supine to upright were significantly greater in pediatric patients with OHT than those in controls.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sympathetic Overactivation From Supine to Upright Is Associated With Orthostatic Hypertension in Children and Adolescents

Wang

et al. 2020

Front. Pediatr.

View full text Add to dashboard Cite

There are no prior publications or submissions with any overlapping information, including studies and patients. The study data have not been presented as an abstract or poster before the submission. Objectives: The study was conducted to analyze the changes of baroreflex sensitivity and heart rate variability from supine to upright standing in children and adolescents with orthostatic hypertension to explore whether and how the autonomic nerve regulation was involved in the development of pediatric orthostatic hypertension. Methods: This case-control study included twenty-five children with orthostatic hypertension (the patient group) and twenty-six healthy controls (the control group). All subjects underwent a standing test, during which their hemodynamic parameters were continuously monitored by a Finapres Medical System, and baroreflex sensitivity and heart rate variability were calculated. Results: The demographic characteristics, supine baroreflex sensitivity, and supine heart rate variability including time domain and frequency domain indices did not differ between the patients with orthostatic hypertension and healthy subjects (P > 0.05). However, a more obvious drop of baroreflex sensitivity and a greater increase of low frequency/high frequency ratio from supine to upright were observed in subjects with orthostatic hypertension compared with those in the healthy children (P < 0.001 and P < 0.01, respectively). Changes of baroreflex sensitivity were negatively related to mean arterial pressure changes from supine to upright in all subjects (P < 0.01), and the increases in low frequency/high frequency ratio from supine to standing were positively correlated with those in mean arterial pressure in the study subjects (P < 0.001). Conclusion: Upright sympathetic overactivation is associated with pediatric orthostatic hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sympathetic Overactivation From Supine to Upright Is Associated With Orthostatic Hypertension in Children and Adolescents

Wang

et al. 2020

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…This is very important to know, because decreased small bowel resorption is a concomitant phenomenon of several diseases and common postoperative consequence. On the other hand, it is also well known that European populations are today affected by several civilization diseases, including overweight and obesity (Doak et al 2012, Honzikova andZavodna 2016). Thus, additional knowledge about the effects of individual food additives on the duodenal morphology is necessary and may result in practical output for dietetic indication and preparation of better nutritional products.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Selected Feed Mixtures on the Duodenal Morphology: Comparison Study

Makovický

Chrenková²,

Fl’ak³

et al. 2018

Physiol Res

View full text Add to dashboard Cite

The objective of this work was to compare the effect of selected feed mixtures on the duodenal morphology. One-hundred-four rats of the Wistar strain were divided to thirteen groups per eight rats. The experiment started in 35-day-old rats after birth and lasted for 32 days. The groups (A-M) were fed by commercial diet, 85 % wheat and 15 % oat diet, 85 % wheat and 15 % triticale, 85 % wheat and 15 % barley, 85 % wheat and 15 % amaranth, 85 % wheat and 15 % lantern, 85 % wheat and 15 % buckwheat, 100 % wheat, 100 % white lupine, 100 % flock peas -variety Garden, 100 % native peas -variety Garden, 100 % native peas -variety Zekon or 100 % extruded peas -variety Zekon diet, respectively. Samples from the duodenum were taken. The height of the villi and the depth of the crypts were measured. The tallest villi were measured in group F (474.33±114.36 µm) and the shortest villi were observed in group B (294.08±88.52 µm). The deepest crypts were measured in group K (166.41±35.69 µm) and the shallowest crypts were observed in group E (77. 85±17.61 µm). The work documents that gluten-free and classical cereals combination can be a better choice for people who want to limit the gluten content of the diet.

show abstract

“…In contrast, no significant differences in the HF power of HRV were observed in other studies between young obese subjects and healthy age-and gendermatched controls (Paschoal et al, 2009;Vanderlei et al, 2010;Javorka et al, 2016). Previous studies also demonstrated an impairment of arterial baroreflex (lower baroreflex sensitivity expressed as heart rate changes related to arterial blood pressure change) in obese children and adolescents, illustrating an impairment of reflex parasympathetic control (Honzikova et al, 2006;Krontoradova et al, 2008;Lazarova et al, 2009;Honzikova and Zavodna, 2016).…”

Section: Introductionmentioning

confidence: 91%

Respiratory Sinus Arrhythmia Mechanisms in Young Obese Subjects

et al. 2020

View full text Add to dashboard Cite

Autonomic nervous system (ANS) activity and imbalance between its sympathetic and parasympathetic components are important factors contributing to the initiation and progression of many cardiovascular disorders related to obesity. The results on respiratory sinus arrhythmia (RSA) magnitude changes as a parasympathetic index were not straightforward in previous studies on young obese subjects. Considering the potentially unbalanced ANS regulation with impaired parasympathetic control in obese patients, the aim of this study was to compare the relative contribution of baroreflex and non-baroreflex (central) mechanisms to the origin of RSA in obese vs. control subjects. To this end, we applied a recently proposed information-theoretic methodology -partial information decomposition (PID) -to the time series of heart rate variability (HRV, computed from RR intervals in the ECG), systolic blood pressure (SBP) variability, and respiration (RESP) pattern measured in 29 obese and 29 ageand gender-matched non-obese adolescents and young adults monitored in the resting supine position and during postural and cognitive stress evoked by head-up tilt and mental arithmetic. PID was used to quantify the so-called unique information transferred from RESP to HRV and from SBP to HRV, reflecting, respectively, non-baroreflex and RESP-unrelated baroreflex HRV mechanisms, and the redundant information transferred from (RESP, SBP) to HRV, reflecting RESP-related baroreflex RSA mechanisms. Our results suggest that obesity is associated: (i) with blunted involvement of non-baroreflex RSA mechanisms, documented by the lower unique information transferred from RESP to HRV at rest; and (ii) with a reduced response to postural stress (but not to mental stress), documented by the lack of changes in the unique information transferred from RESP and SBP to HRV in obese subjects moving from supine to upright, and by a decreased redundant information transfer in obese compared to controls in the upright position. These findings were observed in the presence of an unchanged RSA Frontiers in Neuroscience | www.frontiersin.org 1 March 2020 | Volume 14 | Article 204 Javorka et al. RSA Mechanisms in Obesity magnitude measured as the high frequency (HF) power of HRV, thus suggesting that the changes in ANS imbalance related to obesity in adolescents and young adults are subtle and can be revealed by dissecting RSA mechanisms into its components during various challenges.

show abstract

Baroreflex Sensitivity in Children and Adolescents: Physiology, Hypertension, Obesity, Diabetes Mellitus

Cited by 18 publications

References 65 publications

Sympathetic Overactivation From Supine to Upright Is Associated With Orthostatic Hypertension in Children and Adolescents

Sympathetic Overactivation From Supine to Upright Is Associated With Orthostatic Hypertension in Children and Adolescents

The Effect of Selected Feed Mixtures on the Duodenal Morphology: Comparison Study

Respiratory Sinus Arrhythmia Mechanisms in Young Obese Subjects

Contact Info

Product

Resources

About