Baroreflex mechanisms in major depression

Davydov, Dmitry M.; Shapiro, David; Cook, Ian A.; Goldstein, Iris B.

doi:10.1016/j.pnpbp.2006.08.015

Cited by 83 publications

(110 citation statements)

References 66 publications

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“…Recently, it was reported that depressed patients exhibited reduced parasympathetic-related activity (high HR and reduced HF), as well as a diminished baroreceptor sensitivity (BRS) [13]. The EPDS score was positively associated with the LF/HF ratio during the sleeping hours in the current study, indicating decreased parasympathetic drive with higher depression scores.…”

Section: Discussionsupporting

confidence: 57%

The effect of depression on heart rate variability during pregnancy

et al. 2008

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Depression during pregnancy has been associated with a number of adverse outcomes, but the underlying physiological mechanisms involved remain unclear. The purpose of this study was to examine the effects of maternal depression during pregnancy on the autonomic modulation of heart rate, in a naturalistic setting. Eighty-one pregnant women were studied between 25 and 31 weeks of gestation and were identified as either Depressed (n = 46), or healthy, Control (n = 35), based on depression scores and lifetime psychiatric history. Subjects wore a 24-h Holter recorder to measure time-domain and frequency-domain of heart rate variability (HRV). Pregnant women in the Depressed Group had significantly reduced time-domain measures: standard deviation of all 24-h NN intervals (SDNN) and the standard deviation of the averages of NN intervals in all 5-min segments of the entire recording (SDANN) (P = 0.013, 0.016, respectively), as well as higher heart rates while asleep (P = 0.028), compared to Controls, after controlling for age, smoking, and antidepressant (AD) medication. The low frequency/high frequency (LF/HF) ratio during the sleeping hours was associated with higher depression scores (R = 0.24; P = 0.041). HRV measures improved in women taking AD medication. The autonomic nervous system may be affected in women experiencing depression during pregnancy, indicating a possible decreased parasympathetic (vagal) influence. Women taking AD medication showed some improvement in HRV measures. These data suggest that psychophysiological changes occur in women experiencing depression during pregnancy.

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Section: Discussionsupporting

confidence: 57%

The effect of depression on heart rate variability during pregnancy

et al. 2008

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“…some psychotropic drugs, see Yeragani et al, 1990a) the adaptive cardiovascular arousal responses. The higher age of this cohort excluded the possibility of examining the possibility that sex (as a proxy for hormonal differences before menopause) or biological aging (as a chronologically non-linear process of deficit accumulation; Dawson et al, 1999) may act as a modifier of the moderation effect (Davydov et al, 2007b).…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Depressed mood and blood pressure: The moderating effect of situation-specific arousal levels

Davydov

Stewart

Ritchie

et al. 2012

International Journal of Psychophysiology

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“…Variables indexing reactivity and assessing behaviour-physiology coordination could help to assess individual resources of mental resilience to specific adversity (Davydov & Ritchie, 2009;Phillips et al, 2009;see Figure 2). However, to consider BP activity as adaptive or maladaptive it should be additionally controlled for a coupled reactivity of myocardium metabolism (oxygen consumption) indexed, e.g., by the product of SBP and heart rate (Davydov, Shapiro, Cook, & Goldstein, 2007b). Otherwise, high/low SBP reactivity depends on the environmental context as to whether it is adaptive or maladaptive.…”

Section: Measures Of Mental Resiliencementioning

confidence: 99%

Resilience and Mental Health

Southwick¹,

Litz²,

Charney³

et al. 2011

165

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Humans are remarkably resilient in the face of crises, traumas, disabilities, attachment losses and ongoing adversities. To date, most research in the field of traumatic stress has focused on neurobiological, psychological and social factors associated with trauma-related psychopathology and deficits in psychosocial functioning. Far less is known about resilience to stress and healthy adaptation to stress and trauma. This book brings together experts from a broad array of scientific fields whose research has focused on adaptive responses to stress. Each of the five sections in the book examines the relevant concepts, spanning from factors that contribute to and promote resilience, to populations and societal systems in which resilience is employed, to specific applications and contexts of resilience and interventions designed to better enhance resilience. This will be suitable for clinicians and researchers who are interested in resilience across the lifespan and in response to a wide variety of stressors.

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Baroreflex mechanisms in major depression

Abstract: Background: Recent studies have shown that depressive disorder is associated with

Cited by 83 publications

References 66 publications

The effect of depression on heart rate variability during pregnancy

The effect of depression on heart rate variability during pregnancy

Depressed mood and blood pressure: The moderating effect of situation-specific arousal levels

Resilience and Mental Health

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