Baroreflex function in elderly hypertensives.

McGarry, K; Laher, M; Fitzgerald, D. E.; Horgan, John; O’Brien, E; O'Malley, K

doi:10.1161/01.hyp.5.5.763

Cited by 62 publications

(25 citation statements)

References 16 publications

(7 reference statements)

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“…Kathleen et al [16]. Administered nitroprusside intravenous to change their subjects' baroreflex function, and Bartels et al [17].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Baroreflex Function on Blood Pressure Variability

Wei¹,

Fang²,

Ren³

et al. 2013

IJCM

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Objective: The aim of this study was to assess the relationship of blood pressure variability (BPV) and heart rate variability (HRV) to investigate the effect of baroreflex function on blood pressure variability. Methods: This study consisted of 111 subjects, including 32 normotensives and 79 hypertensives. All the subjects were given two concurrent tests: 24-hour Holter ECG and ambulatory blood pressure monitoring. According to standard deviation of normal-to-normal sinus RR intervals (SDNN) derived from the Holter ECG, the hypertensives were divided into two groups: an HRV normal group with SDNN > 100 ms and an HRV abnormal group with SDNN < 100 ms. HRV analysis used the time domain measure SDNN and two frequency domain analyses using low-frequency and high-frequency power. BPV analysis involved a formula correlated to each blood pressure value. Results: BPV was significantly higher in the HRV abnormal group compared with the HRV normal group in the hypertensives (0.018 ± 0.0033 vs 0.014 ± 0.0032, P < 0.05). In the HRV abnormal group, BPV value of the older hypertensive participants was higher than the younger participants (0.019 ± 0.0024 vs 0.017 ± 0.0037, P = 0.048). BPV and HRV were correlated in the younger hypertensives (r = −0.314, P < 0.05) and older hypertensives (r = −0.692, P < 0.001). Conclusions: Baroreflex function had effect on BPV. Factors like aging could cause damage to the baroreflex sensitivity, which in turn had influence on BPV. There may be benefits in restoration of baroreflex function to reduce BPV, especially in hypertensive patients.

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“…Kathleen et al [16]. Administered nitroprusside intravenous to change their subjects' baroreflex function, and Bartels et al [17].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Baroreflex Function on Blood Pressure Variability

Wei¹,

Fang²,

Ren³

et al. 2013

IJCM

View full text Add to dashboard Cite

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“…Second, the degree of cardioacceleration was markedly reduced with age (see Figure 2). Age-related differences in the heart rate response to postural, hypotensive, and other physiological stimuli 18 " 21 have been extensively described in the literature. Heart rate changes during tilting have been shown to depend mainly on neural influences involving both parasympathetic withdrawal and sympathetic stimulation.…”

Section: Discussionmentioning

confidence: 99%

Tilt test in essential hypertension. Differential responses in heart rate and vascular resistance.

London¹,

Weiss²,

Pannier³

et al. 1987

Hypertension

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SUMMARY Changes in hemodynamic parameters following 50-degree head-up tilt were studied in a population of 56 men, including 35 subjects with sustained essential hypertension and 21 agematched normotensive controls. The increase in heart rate following tilt was similar in both groups and exhibited the same reduction in response with age. The increase in vascular resistance following tilt was strongly and positively correlated with both age and baseline vascular resistance. The latter finding was observed mainly in hypertensive subjects. The study provided evidence that differentiated responses of heart rate and vascular resistance may be observed following orthostasis. In both normal and hypertensive subjects, the age dependence of heart rate response possibly reflected differences in baroreceptor reflex control of parasympathetic and sympathetic activity. In hypertensive subjects, the vascular response was amplified with age and baseline vascular resistance, suggesting a role for structural changes of the vessels in the increased vascular response. (Hypertension 10: 29-34, 1987) KEY WORDS • essential hypertension • baroreceptor reflex mechanisms • orthostasis W HEN a normal person changes from the recumbent to the erect position, the central blood volume and heart volume are decreased and the cardiac output (CO) is reduced by about 20%.'" 3 Diminished CO accompanying reduced peripheral resistance should result in a sharp fall in arterial pressure unless reflex cardioacceleration and vasoconstriction occur at the same time because of the baroreceptor reflex compensatory mechanisms.3 For that reason, baroreceptor reflex mechanisms may be adequately evaluated using passive tilting on a tilt table from the horizontal to the erect position, 4 " 8 during which muscular pumping action of the legs 9 is minimal or absent.The mechanisms resulting in the changes in heart rate and systemic vascular resistance on standing are complex, involving baroreceptors of the high and the low pressure systems and even ergoreceptors in the skeletal muscles.3 ' ltM5 Furthermore, adequate studies

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“…Nevertheless, the attenuation of the baroreflex is far less pronounced in patients in whom the possible effects of disease counteract the age effects (24). Therefore, it is possible that the age-related baroreflex attenuation observed in humans may not be due to aging per se but may instead reflect atherosclerotic and/or hypertensive processes (25,26).…”

Section: So-called 'Cirrhotic' Appearance (Asterisk) Hematoxylin Andmentioning

confidence: 99%

“…It is possible that the age-related baroreflex attenuation observed in humans may not be due to aging per se, but it may reflect atherosclerotic and/or hypertensive processes (14,25,26).…”

Section: So-called 'Cirrhotic' Appearance (Asterisk) Hematoxylin Andmentioning

confidence: 99%