This work aims to classify malaria infected cells from those uninfected using two deep learning approaches. Plasmodium parasite transmitted by a female anopheles's mosquitoes bite is the main cause of malaria. Commonly, Microbiological analyses by a microscope allows detecting cells infected from a blood sample, followed by an specialist interpretation of results to conclude the diagnosis process. Taking advantage of efficient deep learning approaches applied in computer vision field, the present framework propose two deep learning architecture based on Recurrent neural Networks to detect accurately malaria infected cells. The first one implements a Convolutional Long Short-Term Memory while the second uses a Convolutional Bidirectional Long Short-Term Memory architecture. A malaria's public dataset consisting of parasitized and uninfected cell images was used for training and testing the proposed model. The methods developed in this work achieved an accuracy of 99.89 % in the detection of malaria cells infected, without preprocessing data. INDEX TERMS Bidirectional Long Short-Term Memory (BiLSTM), Convolutional Neural Network (CNN), Long Short-Term Memory (LSTM), Malaria 14 inal and chest pain, and the death [2], [3]. Untreated malaria 15 patients may develop long-term pneumonia, anemia, yellow 16 fever, respiratory or brain disorders (Cerebral Malaria) [4].17The World Health Organization (WHO) is deploying 18 strategies for the prevention, treatment, elimination, and 19 surveillance of Malaria to face this global pandemic [1], 20 starting with the diagnosis of the disease. Basically, micro-21 scopic diagnosis method detecting Malaria consist in a mi-22 crobiological analyses using peripheral blood slides [5], [6]. 23 Collection of blood smears for manual microscopic analysis 24 remains an effective method in the diagnosis of Malaria, 25 compared to other methods such as polymerase chain reac-26 VOLUME 4, 2016